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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 151 for “"npc"”.
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Dynamic Procedural Music Generation from NPC Attributes
… thematic music for non-player characters (NPCs) based on developer-defined attributes in real time and responds to the dynamic relationship between the player and target NPC.</p> <p>The system was evaluated by means of user study: participants confront four NPC bosses each with their own …
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Genetic and gene expression analysis of nasopharyngeal carcinoma (NPC)
… expression profiles in Nasopharyngeal carcinoma (NPC). Gene expression profiles identified a large number of differentially regulated genes involved in diverse functional processes, while genetic analysis detected extensive genomic abnormalities including large and small, discrete regions of copy …
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High Power High Frequency 3-level NPC Power Conversion System
… discussed. The 3-level neutral point clamped (NPC) topology is selected to build a 200kVA, 20 kHz power conversion system. The modularized phase leg building block of the converter is carefully designed to achieve low loss and stress for high frequency and high power operation. The switching …
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Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
… two lysosomal proteins: Niemann-Pick C2 (NPC2), a soluble protein of 132 amino acids; and NPC1, a membrane protein with 13 putative membrane-spanning helices. Recessive loss-of-function mutations in either NPC2 or NPC1 produce NPC disease, which causes death owing to lipid accumulation in …
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Structural and biochemical analysis of the Y-shaped Nup84 subcomplex of the NPC
… circular openings are nuclear pore complexes (NPCs), which serve as the gatekeepers, mediating all exchange between the nucleus and the cytoplasm. At its core, the NPC consists of an 8-fold symmetric structural scaffold that serves as a docking site for some of the more dynamic components. …
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A theory and process evaluation of the Learner Engagement Programme (LEP) implemented by Just Grace NPC
Background The Learner Engagement Programme (LEP) is an after school dropout prevention programme that operates in Langa, a township located in Cape Town, South Africa. Langa is an impoverished township characterised by socio-economic challenges, such as high unemployment, violence, few economic …
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Überleben und Differenzierung TAT-Bcl-xL-transduzierter transplantierter neuraler Vorläuferzellen nach zerebraler Ischämie der Maus
… Neurogenese und neurale Vorläuferzellen (NPC) migrieren aus der Subventrikulärzone der Seitenventrikel in das ischämische Areal, tragen jedoch nicht entscheidend zur post-ischämischen Neuroprotektion oder -regeneration bei. Daher könnte die lokale Applikation exogener, adulter NPC in das …
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Plasticity of the Nuclear Pore Complex Revealed With Proteomics
… applied it to the yeast nuclear pore complex (NPC), one of the largest and most elaborate protein machines in the cell. NPC is a massive protein assembly situated in the nuclear envelope and mediating macromolecular transport between the nucleus and cytoplasm. To study the NPC plasticity I have …
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Synthetic ground truth of biological shapes — Simulating variable Nuclear Pore Complexes for Microscopy
The Nuclear Pore Complex (NPC) is the only passageway for macromolecules between the nucleus and cytoplasm and an important reference standard in microscopy: it is intrinsic to cells, has a high copy number, it is massive and stereotypically arranged. The average architecture of NPC proteins has …
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Institutional development of the Chinese National People's Congress (1978-89) : intellectual perspectives
… development of the National People’s Congress (NPC) in the period 1978-89, which was approximately the initial decade of the Post-Mao period of Chinese politics. For the NPC, this period saw the sharpest institutional development, which thus far remains under-researched.The main research …
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Structural elucidation of a common architecture of the nuclear pore complex and COPIl vesicle coats
Nuclear pore complexes (NPCs) are massive protein assemblies that perforate the nuclear envelope and form the exclusive passageway for nucleocytoplasmic transport. NPCs play critical roles in molecular transport and a myriad of other cellular processes. Elucidation of the structure of the NPC is …
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Biophysical Characterization of Structure and Dynamics of Nuclear Pore Complex Components
<p>The Nuclear Pore Complex (NPC) mediates nucleo-cytoplasmic transport in all eukaryotes and is among the largest cellular assemblies of proteins, called nucleoporins (nups). The details of NPC architecture, dynamics, and mechanism are still unknown. NPCs can be dissected biochemically into …
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Structural and biochemical characterization of nuclear pore complex structural scaffold sub-complexes
The nuclear pore complex (NPC) is a large, modular protein assembly that regulates nucleocytoplasmic transport in all eukaryotes. The ~60-120 MDa NPC is a modular assembly of multiple copies of ~30 distinct proteins that are arranged into biochemically distinct sub-complexes. We believe that the …
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Structure and Organization of Nuclear Pore Proteins
<p>The nuclear pore complex (NPC) is a large macromolecular assembly that controls the flow of molecules between the nucleus and the cytoplasm. Elucidating the structure and organization of this complex will be crucial to understanding the mechanism of nucleocytoplasmic transport, but due to its …
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Conformational Dynamics of the Nuclear Pore Complex Studied With Coarse-Grained Modelling and Polarized Light Microscopy
… and dynamics of the nuclear pore complex (NPC) through coarse-grained modelling and polarized-total internal reflection fluorescence (pol-TIRF) microscopy. The NPC is a large (~120 MDa in humans) macromolecular assembly that controls the flow of molecules into and out of the nucleus. The …
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Treatment outcomes of Epstein-Barr virus associated nasopharyngeal carcinoma with three-dimensional conformal radiotherapy: A retrospective review
… virus (EBV) associated nasopharyngeal carcinoma (NPC) largely comes from endemic regions. There is limited literature available regarding the epidemiology and treatment outcomes of EBV associated NPC in South Africa. Aim: The primary aim of the study was to determine overall survival (OS) of …
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The Role of MicroRNAs in Human Nasopharyngeal Carcinoma
… the contemporary era, nasopharyngeal carcinoma (NPC) patients still suffer from a significant risk of distant metastasis (DM). Thus, developing methods to better identify and treat NPC patients at risk of DM is of paramount importance. MicroRNAs (miRNAs) have been shown to provide insight into …
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Proteomic, Bioinformatic and Functional Characterization of the Nuclear Pore Complex of the African Trypanosome
… assemblages known as nuclear pore complexes (NPCs). Yeast and vertebrate NPCs are comprised of about 30 proteins, termed nucleoporins (Nups), which are present in multiple copies. The origins and evolution of the nucleus and NPC are not yet clear, although it seems likely that the nucleus …
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Electrochemical materials and microfabrication for sensor devices
… and optimisation of nanoporous copper (NPC) electrodes across macro- and micro-scale substrates, integrating this material into the microdisk array (MDA) platform to evaluate its potential as an electrochemical sensor and detecting analytes with catalytic affinities to copper. …
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