Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"novel virus"”.
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Expanding inducible epithelial resistance against pneumonia: novel virus, novel receptor
… developed a new model for multi-system coronavirus disease using the murine coronavirus MHV-A59 which infects the respiratory epithelium before disseminating to multiple organ systems. Pam2/ODN treatment decreased morbidity and mortality associated with MHV infection, limited lung injury and …
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Predicting the Interactions of Viral and Human Proteins
… taken place between the proteins of the virus and human proteins. The current computational models for predicting these interactions consider only single viruses for which extensive prior knowledge is available. The two prediction frameworks in this dissertation, DeNovo and DeNovo-Human, …
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The use of reverse genetics to investigate plant-parasite interactions
… thesis demonstrates the development and use of a novel Virus Induced Gene Silencing platform to investigate the interactions of plants and parasites. Host and parasite genes are targeted using this technology which when silenced indicate their involvement in establishing pathogenicity. The several …
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Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
BK polyomavirus (BKPyV) is a small, non-enveloped dsDNA virus that infects 70 – 90% of the world’s population and causes a lifelong, silently persistent infection. In immunocompromised individuals, BKPyV replication can result in serious pathology. Bone marrow transplant patients can develop …
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Molecular characterization of novel soybean-associated viruses identified by high-throughput sequencing
… soybean fields revealed the presence of two novel soybean-associated viruses. The first virus has a single-stranded positive-sense RNA genome consisting of 8,693 nt that contains two large open reading frames (ORFs). The predicted amino acid sequence of the first ORF showed similarity to …
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A RNA Virus Reference Database (RVRD) to Enhance Virus Detection in Metagenomic Data
… in exploring virome composition and discovering novel virus species, there is a pressing demand for comprehensive and up-to-date reference databases to enhance the downstream bioinformatics analysis. In this study, a RNA virus reference database (RVRD) was developed by manual and computational …
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Characterization and Development of a Novel Cytomegalovirus for Evaluation as an HIV Vaccine Viral Vector in a Non-Human Primate Model
… vectors that can induce durable immunity. Herpesviruses, such as cytomegalovirus (CMV), show much promise as viral vectors, as they establish lifelong latency with periodic reactivation, enabling persistent expression of vaccine antigens. We propose that using CMV as a lifelong reactivating HIV …
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Computational Analysis of Viruses in Metagenomic Data
Viruses have huge impact on controlling diseases and regulating many key ecosystem processes. As metagenomic data can contain many microbiomes including many viruses, by analyzing metagenomic data we can analyze many viruses at the same time. The first step towards analyzing metagenomic data is to …
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Discovery and characterization of a newly emerged DENV serotype.
Dengue virus (DENV) is a mosquito-transmitted flavivirus that presents a substantial threat to public health worldwide. One third of the global population is at risk of infection and over 400 million cases of dengue are reported per year. DENV is maintained in two transmission cycles: a sylvatic …
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Mus dunni endogenous virus (MDEV)
… for contaminating replication-competent retroviruses (RCR). RCR was detected using a vector-rescue assay employing Mus dunni cells. We determined that the RCR was being activated from the dunni cells themselves by hydrocortisone present in the patient cell culture medium, and therefore named …
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Discovering Viral Hosts, Mutations, and Diseases using Machine Learning
The discovery of a novel virus raises three important questions, namely, which host(s) can the virus infect, what mutations in the virus could affect its interaction with its hosts and enable a host-shift, and which diseases can the virus cause in humans. We propose novel machine learning …
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Student Experiences of Emergency Remote Learning and Teaching During COVID-19
… is a communicable disease instigated by a novel virus (SARS CoV-2 virus). After the inevitable subsequent national lockdown of South Africa, the university placed ERTL measures in place for the second quarter of the first semester to curb the impact of the virus on its students while also …
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The analysis of genetic aberrations in South African oesophageal squamous cell carcinoma patients
… were designed to identify the possibility of novel viral insertions, investigating Human Endogenous Retroviruses (HERV's) insertions alongside the presence of somatic mutations in patient samples. The aims being to identify integration of any foreign DNA, to investigate if there is any linkage …
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Identification and Characterization of Novel Caenorhabditis Nematode Viruses
… C. elegans; however, until recently, no natural viruses were known, resulting in a limited understanding of virus-host interactions in C. elegans. In lieu of a known C. elegans virus, several studies were conducted by establishing an unnatural virus infection or creating transgenic viral replicon …
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Structure and Function Studies of the Orsay Virus δ Protein
… (C. elegans) as a model organism, the first virus naturally infecting this organism was not discovered until seven years ago. The Orsay virus has a bipartite, positive sense RNA genome, with the RNA 1 segment encoding the RNA-dependent RNA polymerase (RdRP) and the RNA 2 segment encoding the …
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Systems Biology of Host-Pathogen Protein-Protein Interactions
… by the current COVID- 19 pandemic caused by the novel virus severe acute respiratory syndrome coronavirus (SARS-CoV-2). This virus is classified as an obligate intracellular parasite that co-opts host cellular proteins, often through protein-protein interactions (PPIs), to ensure its replication. …
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The spatial and temporal anatomy of seasonal influenza in the United States, 1968-2008
… of the introduction or reintroduction of a novel influenza virus subtype on the spatiotemporal dynamics of influenza spread in the U.S. was performed in the fifth chapter. In the sixth and final chapter, I conclude by summarizing the findings of these four studies. This research found that P …
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Investigating the functional roles of the viral frameshift protein 2B* in EMCV infection
Encephalomyocarditis virus (EMCV) is capable of infecting a wide range of mammalian hosts, causing encephalitis, diabetes, myocarditis in mice and primates as well as reproductive disorders in pigs. The severe pathogenicity is considered to be a result of the rapid cell lysis caused by EMCV. This …
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Assessment of the Zoonotic Potential of a Novel Bovine Influenza Virus
<p>A novel orthomyxovirus was recently identified from pigs, with subsequent work suggesting the natural reservoir being bovine populations. The virus had genome characteristics most similar to influenza C viruses (ICV) but, due to the extent of sequence divergence, was proposed as a new genus, …
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Mining Diverse and Novel RNA Viruses in Transcriptomic Datasets
… data with a goal to identify novel and diverse RNA viruses. For this, I developed a workflow and applied various methods to accommodate and characterize the (un)expected viral diversity. I analysed multiple RNA-sequencing …