Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 101 for “"novel therapeutic strategies"”.
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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… research efforts are underway to discover new therapeutic options to treat PanCa and overcome resistance to available therapies.</p> <p>Mucin, MUC13 is transmembrane glycoprotein, which is aberrantly overexpressed in PanCa and promoting cancer growth. Structural domains of MUC13, lead to …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… of IL10. In this thesis I firstly explored the therapeutic potential of belimumab, an anti-BLyS antibody, in an experimental medicine study in kidney transplant recipients. The rationale for this study was based on published studies showing that B cells activate alloreactive T cells and secrete …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
… This thesis examines two potential novel therapeutic strategies in autoimmunity and MS. The first approach arose from the observation, by previous research at GSK, that there is a population of CD4+ lymphocytes with apparent constitutive pSTAT1 expression independent of any stimulus …
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Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… of disease pathogenesis and for testing of novel therapeutic agents. Donor T-cells, responsible for the initiation disease, require specific signaling pathways and changes in their metabolic profile to sustain their survival, proliferation and differentiation. In cGVHD, activated donor CD4+ …
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NOVEL THERAPEUTIC STRATEGIES IN LUNG CANCERSTRONG BIOLOGICAL BIAS FOR ALK INTRON 19 BREAKPOINTS IN NON-SMALL LUNG CANCER
Chromosomal rearrangements represent one of the most common genomic aberration in cancer and chromosomal translocation that lead to oncogenic kinase activation are observed in many solid tumors. These tumors express activated fusion kinases that drive the initiation and progression of the …
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Identification of targetable mediators of resistance to chemotherapy in oesophageal adenocarcinoma
… overcome resistance to chemotherapy and develop novel therapeutic strategies. This study uses gene expression data to perform unbiased molecular subtyping followed by functional genomic screening to identify novel drug targets to improve outcomes in OAC.<br/><i><br/><br/></i>
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Novel Functions of Cetuximab In Egfr-Targeted Therapy: Radiosensitization, Glycolysis Inhibition, and Cellular Redox Status Regulation
… EGFR-targeted therapy and to develop novel therapeutic strategies to improve the efficacy of cetuximab is urgently needed. In the present study, we elucidated the mechanism of cetuximab in radiosensitization, and discovered novel functions of cetuximab in glycolysis inhibition and …
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Molecular Mechanisms That Govern Human Cardiac Stem Cell Age Disparity
… regenerative ability with age and investigate novel therapeutic strategies to improve cardiac stem cell function. When comparing neonatal and adult cardiovascular stem cell clones, both cell types were capable of cardiomyogenic differentiation. However, the expression levels of forty-one …
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Molecular function and regulation of the Bax-associating protein MOAP-1
… an important implication for conceptualizing novel therapeutic strategies in combating human diseases.
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… of NGF-responsive neurons in may allow for novel therapeutic strategies.
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A role for iron in oesophageal adenocarcinoma
… between benign and malignant tissue may permit novel therapeutic strategies in the future.
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INSIGHTS INTO THE SELECTION AND FUNCTION OF COPY-NUMBER ALTERATIONS DURING CANCER EVOLUTION
… new potential vulnerabilities that could inform novel therapeutic strategies.
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Translational phosphoproteomics methods to identify biomarkers and novel therapeutic targets
… mediated signaling networks in tumors can inform therapeutic interventions. Additionally, analysis of phosphoproteome in response to drug candidates can help identify biomarkers for therapeutic response as well as lend direct insights into potential adaptive resistance mechanisms. However, …
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Mechanisms of Intercellular Communication During Breast Cancer Progression Through Metastasis
… these interactions is necessary to develop novel therapeutic strategies. One mechanism that facilitates metastasis is epithelial-mesenchymal transition (EMT), which can be induced in cancer cells following the secretion of growth factors by tumor-associated macrophages (TAMs). During EMT, …
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The Development of a Xenograft-based Scaffold for Tendon and Ligament Reconstruction
… may potentially contribute to the development of novel therapeutic strategies in areas of ligament and tendon reconstruction surgery. Currently there is a limited supply of donor tendons available for surgical reconstruction. The goal of tissue engineering is to develop scaffolds to replace …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… in many cancers and there is a need to develop novel therapeutic strategies. In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were evaluated. Cancer cells are dependent upon aerobic glycolysis (the Warburg effect) and glutamine …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… in many cancers and there is a need to develop novel therapeutic strategies. In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were evaluated. Cancer cells are dependent upon aerobic glycolysis (the Warburg effect) and glutamine …
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Engineering cellular microenvironments for directed cell growth and migration
… mechanisms and should aid in the design of novel therapeutic strategies to treat human health disorders.
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Suppression of the Ubiquitin Ligase Function of FBXW7 Accelerates Metastatic Progression of Pancreatic Ductal Adenocarcinoma
… progression to metastasis. This study addresses novel facets of PDAC metastasis which has the potential to identify novel therapeutic strategies for advanced and metastatic disease.
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