Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 125 for “"novel protein"”.
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The functional characterization of a novel protein, Liat1
… in our lab by its interaction with Arginyl tRNA-protein transferase-1 (Ate1), a component of the N-degron pathway of protein degradation. However, its functional significance remains unknown. This study is the first functional characterization of Liat1. Here, we found that the N-terminal half of …
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Towards the synthesis of novel protein phosphatase inhibitors
Protein phosphatases (PPases) are important enzymes which mediate dephosphorylation of proteins in eukaryotic cells. These enzymes are involved in a variety of cellular processes, and disruption of their activity has been shown to be involved in the development of diseases such as cancers and …
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Development and Characterization of a Novel Protein Stability Probe
… MYC stability. Current strategies to measure protein half-life are low-throughput or prone to false readouts, and have hampered the discovery of novel regulatory pathways for MYC that could be targeted therapeutically. To overcome this barrier, we developed a protein stability probe, …
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Identification of novel protein kinase regulators of TGFβ signalling
… cell line in order to identify potential novel regulatory components of the TGFβ signalling pathway. From this screen and subsequent validation experiments, I observed that three structurally unrelated small-molecule inhibitors that target the salt-inducible kinases (SIKs) are able to …
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Split Inteins: From Mechanistic Studies to Novel Protein Engineering Technologies
<p>Inteins are auto-processing protein domains that carry out a post-translational process known as protein splicing. This process is characterized by excision of the intein (intervening protein) domain from within a larger polypeptide sequence with concomitant ligation of the flanking extein ( …
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Insect meals as novel protein sources in retorted pet food for adult cats
Insect meals are novel and potentially sustainable protein sources. The objective of this study was to determine the chemical composition of 3 selected insect meals [i.e., speckled cockroach (SC), madagascar hissing cockroach (MC) and superworm (SW)] and to determine the effects of these novel …
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Enhanced Proteomic Methods to Decipher How the Novel Protein SNED1 Modulates the Extracellular Matrix
… matrix (ECM) is a complex meshwork of proteins that provides not only structural support but also biochemical cues to cells. The assembly of the ECM is a dynamic process requiring precise coordination: 1) ECM proteins are produced, post-translationally modified, and then secreted into …
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Alternative diet formats and novel protein ingredients for use in canine and feline diets
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Novel Protein-protein Interactions Regulate The Proteolytic Activity Of The Pro- Apoptotic Serine Protease, Omi/htra2
… with high homology to the bacterial HtrA proteins. Omi promotes caspase-dependent apoptosis by binding and degrading IAPs-inhibitor of apoptosis proteins. Omi can also induce caspase-independent apoptosis but the actual mechanism is still unknown. IAP's are not the only substrates cleaved …
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Functional analysis of novel protein-protein interactions involving ROP GTPases in Arabidopsis thaliana and Populus trichocarpa
… the yeast two-hybrid (Y2H) system to identify novel protein-protein interactions (PPI) relevant to wood formation. Bait proteins for Y2H binary assays and screening against a xylem cDNA prey library were selected from approximately 400 Populus trichocarpa genes that are at least 8-fold more …
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Members of the Preprotein and Amino Acid Transporter Family Constitute Components of Novel Protein Import Pathways into Chloroplasts
… plastid types must import the majority of their proteins from the cytosol across the envelope membranes. Translocons at the outer and inner chloroplast envelope membranes, called TOC and TIC, were identified that mediate the import of proteins. N-terminal transit peptides essential for import of …
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Identification And Functional Analyses Of Novel Protein Interactions And Post-Translational Modifications For The Transcription Factor Deformed Epidermal Autoregulatory Factor-1.
… order to further our understanding of the DEAF-1 protein, this study characterizes previously unidentified DEAF-1 interacting proteins and post-translational modifications of DEAF-1. A region encompassing the DNA binding domain of DEAF-1 interacts with the C-terminal Bax interacting domain of the …
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The identification and characterization of the interaction between Upf1 and PAB1 during nonsense-mediated decay & the identification of novel protein complexes associated with translation termination factor eRF1
<p>There are still many protein interactions that occur during translation termination that are poorly understood. One of the important termination pathways still under investigation is nonsense-mediated decay (NMD), which rapidly degrades mRNAs that contain a premature stop codon (PTC). I …
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Mechanical integrity and rehydration properties of agglomerated nutritional dairy ingredient powders
… conveying) post-spray drying, while presenting novel research findings in the application of agglomeration for the modification of commercially important, high-protein content dairy powders (e.g., milk protein isolate; MPI). Initially, a custom fabricated pressure dispersion rig was utilised to …
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Alergia alimentar - temporalidade X antigenicidade
… in a subsequent immunization to a non-related protein. Conversely evaluate the consequences of the introduction of a novel protein in the diet of animals presenting an inflamed gut. MATERIAL AND METHODS Adult, male and female C57BL/6J mice. In the first experiment, animals were submitted to …
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Identification and Characterization of Pat-6/actopaxin in Caenorhabditis Elegans Body Wall Muscle
In addition, I identified PAT-4/ILK and a novel protein, K10B2.5, as putative binding partners of PAT-6/actopaxin. PAT-6/actopaxin and PAT-4/ILK colocalize in vivo, forming a multi-protein complex with UNC-112. The accumulation of PAT-6/actopaxin in body wall muscle cells requires PAT-4/ILK kinase …
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Evolutionary Fitness of Non-Coding Genetic Elements
Proper protein structure and function are integral to cellular homeostasis. The wide array of known natural protein sequences are a product of millions of years of evolutionary pressure maintaining physical stability and biological function. The evolutionary process occurs via random instances of …
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Characterization of the genes and gene products of the acetate-activating enzymes and a novel iron-sulfur flavoprotein from Methanosarcina thermophila strain TM-1
… The <i>orfY</i> gene appears to encode a novel protein whose physiological function has yet to be determined.
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The control of starch degradation in Arabidopsis thaliana leaves at night
… is exhausted by dawn. The mechanisms and the proteins involved in controlling starch degradation rates are largely unknown. With my work I wanted to identify components involved in the control of starch degradation rates. Using a forward genetic screen, I discovered several mutants with new …
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Protein Engineering via in Vitro Coevolution
The creation of novel protein functions represents a significant challenge in protein engineering. To address this challenge, I have developed a simple and efficient method---in vitro coevolution---for the creation of novel protein functions in an existing protein scaffold. The in vitro coevolution …
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