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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 82 for “"novel peptide"”.

  1. Hv1 novel peptide inhibitor extracted from tarantula venom

    Rahpeymaei, Ali2024

    … investigates the interaction between GsAF-I, a peptide from the venom of the tarantula Grammostola rosea, and human voltage-gated proton (Hv1) channels, critical in pH regulation and cellular signaling. Utilizing patch clamp techniques on genetically modified Chinese Hamster Ovary cells …

    debrecen Repository record

  2. The discovery of a novel peptide, QUB-2023, from Rana amurensis

    Han, KunQueen's University Belfast2017

    The abundant antimicrobial peptides (AMPs) discovered in amphibian skin secretions have raised the interest of many researchers not only because of their broad spectrum of actions against many clinically-relevant microorganisms but also their superiority over conventional antibiotics.<br/><br/>This …

    qu-belfast Repository record

  3. Development of Novel Peptide-Doxorubicin Conjugates for Targeting Triple-Negative Breast Cancer

    Saghaeidehkordi, Azam2023

    … the cancer cells, I have synthesized three peptide-drug conjugates (PDCs) to specifically target the TNBC cells. The first PDC contains peptide 18-4 with an additional cysteine in the N-terminal (NH2- CWxEAAYQrFL-CONH2) linked to aldoxorubicin (Aldox), a modified version of a common …

    chapman Repository record

  4. Novel peptide antigens provide insights into the recognition process by T cells

    Narayanan, SamanthiUniversity of Illinois at Urbana-Champaign2014

    … and the reactivity of T cell receptors with novel peptide antigens. The first study (Chapter 2) described a collection of novel peptide antigens for a single T cell receptor and their diverse requirements for the co-receptor CD8. One of the peptides showed no activity despite binding the TCR, …

    uiuc Repository record

  5. The discovery of a novel peptide from the defensive skin secretion of Hylarana guentheri

    Chen, LingzhuQueen's University Belfast2017

    … compounds. To date, thousands of proteins and peptides with diverse biological activities have been isolated from amphibian skins. Antimicrobial peptides (AMPs) are one of the most essential groups of these molecules. AMPs are relatively small molecules, which have recently been considered as a …

    qu-belfast Repository record

  6. Novel peptide-based approaches to study the activity and substrate specificity of protein kinases

    Kamaruddin, Mohd Aizuddin2013

    … diseases. This thesis sought to develop new peptide-based approaches to studying the activity and other properties of kinases, with an ultimate view towards improving our understanding of the mechanism of aberrant regulation of protein kinases and how dys-regulated protein kinases direct …

    melbourne Repository record

  7. The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer

    Than, Phi-Phung2024

    … alopecia and gastrointestinal problems. A peptide-drug conjugate (PDC) targeting overexpressed epidermal growth factor receptor (EGFR) in TNBC cells was synthesized to increase the uptake of drug by TNBC cells, thereby improving the safety and efficacy of chemotherapeutic doxorubicin (Dox) …

    chapman Repository record

  8. QUB-3170: a novel peptide with antimicrobial activities from the skin secretion of Phyllomedusa tarsius

    Zhou, QinrongQueen's University Belfast2018

    … be discussed as a necessity. Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi, viruses, bacteria, and even tumour cells. On the other hand, antimicrobial peptides are considered as an essential product of amphibian skin secretions, the skin secretion …

    qu-belfast Repository record

  9. The discovery of the novel peptide QUB-2049 from the skin secretion of Odorrana versabilis

    An, JinqiQueen's University Belfast2021

    … developed. To solve this problem, bioactive peptides obtained from the skin of amphibians have been extensively studied. Nowadays, some antimicrobial peptides from frog skin have been investigated for their bioactivities. The aims of this research project are to find a new AMP from the skin …

    qu-belfast Repository record

  10. A novel peptide QUB-2562, discovered from the skin secretion of the frog, Agalychnis annae

    Gong, RoujiaQueen's University Belfast2019

    … antibiotic agents.<br/><br/>In this project, a novel peptide QUB-2562 derived from the skin secretion of Agalychnis annae was identified by molecular cloning. Solid-phase synthesis was applied to synthesise the novel peptide. After the synthesis, High Performance Liquid Chromatography (HPLC) and …

    qu-belfast Repository record

  11. The discovery of a novel peptide, QUB-2274, from the defensive skin secretion of Rana amurensis

    Xu, YiwenQueen's University Belfast2017

    … especially the broad-spectrum antimicrobial peptides, which have attracted increasing attention as potential therapeutic agents.<br/><br/>In this thesis, a novel bioactive peptide was discovered in the skin secretion of Rana amurensis. This skin secretion was collected by mild electrical …

    qu-belfast Repository record

  12. Identification and bioactivity evaluation of a novel peptide from the skin secretion of Pelophylax kl. esculentus

    Li, YaoQueen's University Belfast2017

    … in their skin or skin secretions. Among these, peptides are found with broad-spectrum antibacterial and antifungal activities, as well as anticancer properties. It is generally assumed that these cationic, amphipathic and α-helical peptides constitute a part of the innate immune system that …

    qu-belfast Repository record

  13. The discovery and functional assessment of novel peptide QUB-2686 from Red-eyed tree frog, Agalychnis callidryas

    Wang, HaoQueen's University Belfast2018

    … against microorganisms, parasites and predators. Novel peptides with pharmacological activities are constantly being discovered in amphibian skin secretions. Thus, the aim of this study is to identify a novel peptide with bioactive function, which would contribute to the development of new drugs. …

    qu-belfast Repository record

  14. Identification, isolation and bioactivity assessment of a novel peptide from the skin of Heilongjiang Brown Frog (Rana amurensis)

    Gan, XiaoyangQueen's University Belfast2018

    … substance form skin secretions, various peptides or proteins, was considered as treasures in medical treatment. The mechanism of antimicrobial peptides (AMPs) on antimicrobial activities was different from antibiotics and AMPs exhibit considerable value against antibiotic …

    qu-belfast Repository record

  15. Discovery and bioactivity assessment of a novel peptide from the skin secretion of the Senegal running frog Kassina senegalens

    Zhou, ChunyuanQueen's University Belfast2021

    … abundance of biologically active antimicrobial peptides (AMPs) with a broad-spectrum effect against a variety of microorganisms. The contribution of their complex and diverse structures, physicochemical properties and mechanisms of biological activity, have been discovered and widely reported. …

    qu-belfast Repository record

  16. Bioactive evaluations of novel peptide QUB-2552 from the skin secretion of the Chinese Large Odorous frog, Rana (Odorrana) livida

    Zhang, YujingQueen's University Belfast2018

    … skin secretions are rich resources of bioactive peptides, some of which could be developed as drug candidates. Among these natural peptides, antimicrobial peptides have attracted great attention given that they might help to deal with the problem of antibiotic resistance. In this study, the …

    qu-belfast Repository record

  17. SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME

    Pandya, Hetal VinodWake Forest University2011

    Glioblastoma multiforme (GBM) is a primary brain tumor of dismal prognosis. Patients with GBM have a median survival rate of 14.5 months inspite of multimodality treatment involving surgery, radio- and chemotherapy. This warrants an intensive search for efficient new therapies. Interleukin 13 …

    wfu Repository record

  18. Characterization of Rheumatoid Arthritis-Specific Immune Responses and Evaluation of a Novel Peptide Immunotherapy in the Collagen Induced Arthritis Mouse Model

    Kitchen, Jaspreet KaurThe University of Western Ontario2026

    … citrullinated and homocitrullinated proteins/peptides (CitP and HomoCitP). To study RA, mice with collagen induced arthritis (CIA) are commonly used; however, it remains unclear whether this pre-clinical model adequately represents disease-specific autoimmune responses. Therefore, this thesis …

    uwo Repository record

  19. Identification, isolation and bioactivity assessment of a novel peptide from the skin secretion of the Tiger-striped Leaf Frog (Phyllomedusa tomopterna)

    Chen, ZiqiQueen's University Belfast2019

    … early twentieth century, the first antimicrobial peptide was found. Nearly forty years later, antimicrobial peptides from frogs were discovered, after which, frogs and their skin secretions were treated as a great source of peptides with bioactive functions. Results from decades of research have …

    qu-belfast Repository record

  20. The discovery and bioactivity evaluation of a novel peptide, QUB-2652, from the skin secretion of the South American frog, Phyllomedusa palliata

    Dong, ZiyiQueen's University Belfast2018

    … development of new antibiotics. Antimicrobial peptides (AMPs) from amphibian skin secretions possess broad-spectrum antimicrobial activities through the mechanism that is unlikely to induce antibiotic resistance. Thus, AMPs are great candidates for new antibiotics. <br/>In this study, the …

    qu-belfast Repository record

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