Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"novel object recognition task"”.
-
Validation of an animal model of cognitive dysfunction associated with schizophrenia. Development and validation of the novel object recognition task using behavioural manipulations and psychotomimetic dosing regimens to induce cognitive deficits of relevance to schizophrenia in hooded-Lister rats.
… reported in chapter 3 were to establish a set of objects with equal preference in the NOR (novel object recognition) test. Furthermore, the inter-trial-interval (ITI) of the NOR test was investigated in an attempt to elucidate the effects of time and location of the rats during the ITI on the …
-
EFFECTS OF AT1R ANTAGONIST L-158,809 ON NORMAL BRAIN TISSUE INJURY FOLLOWING WHOLE-BRAIN IRRADIATION
… L-158,809, ameliorated impairment in the novel object recognition task after fractionated WBI. The work in this dissertation tested the hypothesis that blocking the intrinsic brain RAS with L-158,809 before, during, and after WBI would prevent radiation-induced neurobiological changes. The …
-
Cognitive and synaptic dysfunction in a mouse model of Huntington's disease
… characterise the early stages of HD. A series of recognition tasks were used to assess the episodic memory of the HdhQ111 mouse. Although these tasks had been used to assess the ability of rats to discriminate the ‘what’, ‘where’ and ‘when’ of episodic memory, this was the first time that they had …
-
Experimental and Finite Element Evaluation of Mild Traumatic Brain Injury
… evaluations using Rotarod and Open Field tasks, along with histological markers (GFAP, Iba-1, and tau protein), demonstrated that multiple blast exposures resulted in more severe motor deficits and neuroinflammatory responses than single exposures. This highlights cumulative injury risks. …
-
Robustness of Novelty Preference For A Motion-Based One-Trial Object Recognition Task In Male and Female Adolescent Rats
<p>One-trial object recognition (OR) is a popular paradigm for conducting stress-free studies of rodent recognition memory. Rodents' response to novelty depends upon complex interactions between intrinsic and extrinsic motivations, many of which decrease validity for measures operationally defining …
-
Exploration of cognitive and neurochemical deficits in an animal model of schizophrenia. Investigation into sub-chronic PCP-induced cognitive deficits using behavioural, neurochemical and electrophysiological techniques; and use of receptor-selective agents to study the pharmacology of antipsychotics in female rats.
… set-shifting, operant reversal learning, and novel object recognition tasks. The pharmacology of antipsychotics was studied in the reversal learning task using receptor selective compounds. Following this, experiments were carried out using in vitro electrophysiology and in vivo microdialysis …