Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 139 for “"novel genes"”.
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Identification of Novel Genes Involved in Female Mating Choice
… I focused on a group of highly divergent genes from three closely related Drosophila species in which females display very distinct mating choices. Here, I tested whether 45 of such genes had effect on female mating using RNA interference and identified eight genes that either produced …
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Molecular and cellular expression of novel genes associated with breast cancer
… monitoring of the disease and development of novel therapies. As such, this study proposed to characterise and evaluate the potential for the management of breast cancer of four novel unpublished breast-associated genes, the breast-associated UniGene clusters (BUC6, BUC9, BUC10 and BUC11), …
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Characterization of novel genes involved in cell envelope function in Rhizobium leguminosarum
… this research was to identify and characterize novel genes involved in cell envelope development in Rhizobium leguminosarum. Previous studies have identified a positive correlation between cell envelope defective mutants and an inability to grow on peptide-rich media, as well as minimal media …
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BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… recur as invasive breast cancer. To identify the novel regulators of DCIS progression, we performed gene expression analysis of syngeneic cell lines MCF10A, DCIS.com and MCF10CA and cross-referenced the targets using patient cohorts. By comparing gene expression between MCF10A and DCIS.com cell …
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Cloning and functional characterization of novel genes expressed preferentially in the human retina
… Therefore, isolation and characterisation of the genes active in the human retina will facilitate our deeper understanding of retinal physiology and mechanisms underlying retinal degeneration and provide novel candidates for the retinal disease genes. To identify novel genes that are specifically …
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Novel genes required for proper cell envelope function in the plant symbiont Rhizobium leguminosarum
… this research was to identify and characterize novel genes required for proper cell envelope development in the legume symbiont Rhizobium leguminosarum. In R. leguminosarum there is a positive correlation between mutations that affect cell envelope structure and sensitivity to peptide-rich …
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Identification and Functional Characterization of Novel Genes Involved in Primary Neurogenesis in Xenopus laevis
… ist ein gutes System für das Studium der Neurogenese in Vertebraten. Bereits früh, im offenen Neuralplattenstadium, wird das Gebiet der primären Neuronen durch eine Gruppe von neuralen Genen definiert, die in einem typischen Muster in Form von Streifen exprimiert werden und die drei bilaterale …
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An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
… characterize the in vivo physiological role of novel downstream target genes of these transcription factors: StARD5 and ADAM11. This thesis outlines the development and characterization of a floxed mouse allele of the UPR-upregulated, reticuloendothelial gene StARD5, as well as two different …
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Analysis of Novel Genes Whose mRNAs are Enriched in the HVC-Associated Telencephalon of Songbirds
… demonstrated that 4 of these clones encode novel proteins with suggestive or recognizable. Functional domains: HAT-2 contains regions of homology to a regulatory domain in Protein Kinase C (PKC) and to a GTPase activating domain in the bcr oncogene; HAT-S encodes a protein kinase; HAT-14 …
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Identification of novel genes regulated by innervation and characterization of subsynaptic proteins in skeletal muscle
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Uncovering novel genes causing isolated gonadotropin releasing hormone deficiency using runs of homozygosity in outbred families
… puberty and infertility. Over 30 causal IGD genes have been discovered, yet only 30-35% of IGD cases have a proven genetic etiology, highlighting the importance of new discovery methods. Homozygosity mapping, traditionally used to detect autozygous segments in inbred populations, has recently …
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TWO NOVEL GENES DOWNSTREAM OF THE FLORIGENIC AND THE PHOTOPERIODIC INDUCTION CONTROL RICE PLANT DEVELOPMENT IN THE REPRODUCTIVE STAGE
Il riso (Oryza sativa L.) è una pianta a giorno corto facoltativa appartenente alla famiglia delle Poaceae. È una specie modello per le piante erbacee a causa del genoma relativamente piccolo e la facilità di gestione, in particolare quando si tratta di studiare network genetici complessi come …
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Identification and characterization of novel genes involved in DNA double strand break repair process in the yeast Saccharomyces cerevisiae
… DSBs and/or mutations in key DSB repair genes can lead to genomic instability, cancer or even cell death. DSBs can be repaired by two independent pathways; Homologous Recombination (HR) and Non-Homologous End Joining (NHEJ). Both pathways are highly conserved from yeast to human. HR …
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MULTI-OMICS APPROACHES TO CHARACTERIZE PATIENT-DERIVED SPINAL CORD ORGANOIDS AND ASSESS NOVEL GENES ASSOCIATED WITH C9ORF72-AMYOTROPHIC LATERAL SCLEROSIS
… goal of this project was to unravel the role of genes, proteins, and pathways of interest by applying integrated multi-omics approaches to spinal cord organoids (SCOs) generated from patient-derived induced pluripotent stem cells (iPSCs) and isogenic lines obtained with CRISPR/Cas9 technology. …
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A functional study on novel genes involved in regulating aldosterone secretion in normal human zona glomerulosa and in aldosterone-producing adenomas
… profile. It is unknown if the process of tumorigenesis differs between ZG- and ZF-like APAs. In order to define ZG specific genes, we have compared the transcriptome of APAs and their adjacent adrenal glands by microarray assay. RNA was isolated by laser capture microdissection (LCM) from …
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Identification and Investigation of Novel DNA Damage Repair Genes Via Network Analysis
… leads us to believe there are more undiscovered genes in this pathway. The highly complex and conserved nature of DSB repair across eukaryotic and mammalian cells presents an opportunity for identification of novel genes through a computationally-directed approach. Employing a …
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Exploring the transcriptomic landscape of the Drosophila melanogaster embryonic salivary gland.
… effectors responsible for controlling the morphogenesis of tubes and their order of action is yet to be comprehensively assessed. To investigate this, I utilised a simple model of tubulogenesis found in the Drosophila melanogaster embryonic salivary gland. Once specified, two mirror-symmetric …
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Identification of germline variants that predispose to familial melanoma
… the genetic factors that contribute to the pathogenesis of melanoma are yet to be defined. This project aims at identifying novel genes and pathways involved in the development of familial melanoma, and also identify loci which predispose individuals to disease development. 308 individuals from …
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Investigation into the role of DWNN in cell death
Many genes are activated to influence the self-destruction programme of the cell. This programme entails synchronised instigation and implementation of numerous subprograms. The arrival of gene targeting aided in the determining of the functions of novel genes. Such genes may have been sequenced, …
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