Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 92 for “"novel function"”.
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A novel function for the eukaryotic translation elongation factor 1A
… demonstrated both by photo-crosslinking and by a functional refolding assay. Furthermore, it is shown that the interaction of the nascent polypeptide chain with eEF1A can be competed out with a variety of short peptides. However, the found minimum length of 20-30 amino acids for these short …
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Novel function and regulation of mutagenic DNA polymerases in Escherichia coli
… revealed that umuC+ and its homolog dinB+ encode novel, low to moderate fidelity DNA polymerases with the ability to catalyze synthesis on imperfect DNA templates in a process termed translesion synthesis (TLS). Similar enzymes exist in nearly all organisms, constituting the Y-superfamily of DNA …
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The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant
… and antioxidant qualities of CRN provide novel potential therapeutic roles for CRN which is largely thought to be a waste product.
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A novel function of enteropathogenic Escherichia coli secreted protein F within intestinal epithelial cells.
A novel function of enteropathogenic Escherichia coli secreted protein F within intestinal epithelial cells.
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A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
… However, the homeostatic signaling functions of beta4's cytoplasmic tail can be hijacked by growth factor receptors during tumor growth to promote tumor cell survival and metastasis. Beta4 interacts with 12-LOX, an enzyme that metabolizes arachidonic acid to yield 12(S)-HETE, a …
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A Novel Function For Aurora B Kinase In The Regulation of P53 By Phosphorylation
… while other phosphorylation sites did not. On a functional level, Aurora B was shown to reduce p53’s capacity to mediate apoptosis in response to the DNA damaging agent, cisplatin. These results define a novel mechanism for p53 inactivation by Aurora B and imply that oncogenic hyperactivation or …
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Investigating a novel function of histone H3 in mitotic checkpoint control in Saccharomyces cerevisiae
Thesis (Ph. D.)--Michigan State University. Dept. of Biochemistry and Molecular Biology, 2010
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A novel function of tissue inhibitor of metalloproteinase-1 as a chemoattract molecule for neural stem cells
Recently neural stem cells (NSCs) were reported to migrate to damaged brain area, such as brain tumor or ischemic region. So, we hypothesized that human glioma or ischemic tissues secreted chomoattract molecules that induce NSC migration toward that area. In present study, we reported one candidate …
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The Mycobacterium tuberculosis KatG gene : identification of a novel function and analysis of the regulation of expression
… that the M tuberculosis katG gene may encode a novel function related to the repair of DNA damage, and this may have implications for the survival of M tuberculosis in the presence of DNA damaging agents, for example, in the macrophage. UV sensitivity tests on M intracellulare and M tuberculosis …
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Revealing the Mechanism Underlying the Beneficial Effects of Angiotensin-Converting Enzyme Inhibitors in a Drosophila Alzheimer’s Disease Model
… reporting no effects. How these drugs may function in AD remains poorly understood, although it is independent of their ability to regulate blood pressure. Given their therapeutic potential, our lab has been interested in evaluating the effects of ACE-Is and determining their mechanism of …
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The Role of Epigenetics in the Regulation of Meiotic Recombination in Triticum aestivum and Arabidopsis thaliana
… cell division unique to eukaryotes that functions to increase genetic diversity in offspring. Crossover formation is an outcome of the process of meiotic recombination, a cascading series of events during which homologous chromosomes undergo pairing and reciprocal exchange of genetic …
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Mammalian-wide interspersed repeats (MIRs) and their role in mammalian gene function and evolution
… of these elements can provide additional or novel function for endogenous genes. Mammalian-wide interspersed repeats (MIRs) are short interspersed nuclear elements (SINEs), belonging to the non-autonomous class of retroelements and are found in all mammals. The recruitment of an MIR element …
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Sumo-Specific Protease 1 Controls Lymphoid Development Through Regulation of Sumoylation/Acetylation Switch In Stat5
… as an important regulatory mechanism for protein function. SUMO-specific proteases (SENPs) are essential for removing SUMO from conjugated proteins in many different systems, but the physiological functions of SENPs are poorly understood. STAT5 (Signal Transducer and Activator of Transcription 5) …
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The Role of Cell Division Orientation during Zebrafish Early Development
… there is little direct evidence for a critical function of SDO in either of these processes. Making use of extended time-lapse, multi-photon microscopy and a careful three-dimensional analysis of cell division orientation, we show that SDO is required for neural rod midline formation during …
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The role of PADs in the biogenesis of prostate cancer microvesicles which play a dysfunctional role on DC biology and the therapeutic potential of skeletal muscle microvesicles on prostate cancer cells
… cancer. Aspects of MV biogenesis and function have therefore become emerging targets for further research and cancer therapy. In light with the current research this thesis reports for the first time a novel function of peptidylarginine deiminase (PAD) isozymes (elevated in cancer …
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Functional Genomic and Image-Based Screening Approaches for Probing Host-Pathogen Interactions
… this thesis, I describe approaches to leverage functional genomics and image-based screening to perturb and profile host-pathogen interactions, including responses to two RNA viruses, Sendai virus and Ebola virus. These provide case studies highlighting the utility of high-content image-based …
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Structural and functional studies of heme binding proteins toward the understanding of malaria
… of proteins. Herein, we report on the novel heme-binding properties of both proteins. We have identified a novel function of mRuby2, a commonly used fluorescent probe. Upon incubation with heme, the fluorescence of mRuby2 decreases, providing a potential use for the protein as a heme …
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Crosstalk between CX3CL1 and the Cytoskeleton during Vascular Inflammation
… the progression of atherosclerosis. I document a novel cytoskeletal regulatory mechanism that limits the interactions between CX3CL1 and the membrane-associated protease ADAM10, thereby controlling the proteolytic release of soluble chemokine. Moreover, I discuss the implications of this mechanism …
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Protein Semi-Synthesis in Vivo
… elucidate biological processes and to engineer novel function. This thesis describes the ligation of synthetic molecules to target proteins in an intracellular environment, and the use of semi-synthetic proteins for whole animal studies. In the first approach a cellular protein is genetically …
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