Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"novel formulation"”.
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
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Evaluation of Anti-cancer effect of a Novel Formulation from Umbilical Cord Blood Stem CellDerived Exosomes and Retinoic acid as a potential therapeutic candidate against Malignant Melanoma
This study focused on two potential therapeutic modalities with good safety profiles, i.e., Retinoic acid (RA) and Umbilical cord blood stem cell (CBSC)-derived exosomes as an anti-cancer drug. The current in vitro study has evaluated the genotoxicity and cytotoxicity of RA and CBSC-derived …
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The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development.
… in-situ and post actuation to adequately direct formulation strategies for the production of stable and efficacious suspension and solution based products. Characterisation methods have been applied to pMDI dosage systems to gain insight into solubility in HFAs and to determine forms of solid …
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Spectrokinetic studies of the photostability and the photodegradation of Diethylstilbestrol
… complex also enabled the preparation of a safe formulation of the CD/drug complex by fully dissolving the complex in water resulting in the solubilisation of water insoluble DES. This was followed by analysis of the complex using ATR-FTIR and SEM methods. The results indicated a strong …
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Optimal long-term financing under ambiguous volatility
… of the project cash flows. I describe a novel formulation that captures uncertainty about the underlying volatility process show how it affects the optimal contract. Ambiguity aversion generates endogenous belief heterogeneity between the principal and the agent. Under the optimal …
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New optimization approaches to matrix factorization problems with connections to natural language processing
In this thesis, we propose novel formulation optimization methods for four matrix factorization problems in depth: sparse principal component analysis, compressed sensing, discrete component analysis, and latent Dirichlet allocation. For each new formulations, we develop efficient solution …
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Computational illumination for portrait photography and inverse graphics
… photography. The thesis also discusses a novel formulation for fast and accurate differentiable rendering based on analytical anti-aliasing. It is demonstrated how this renderer can be used for inverse graphics problems. The thesis concludes with a discussion on how differentiable …
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Goal alignment: re-analyzing value alignment problems using human-aware AI
… objective. To address this, we propose a novel formulation for the objective misspecification problem that builds on the human-aware planning literature, which was originally introduced to support explanation and explicable behavioral generation. Additionally, we propose a …
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Design, synthesis, and characterisation of transition-metal dicarboxylate anodes for lithium-ion batteries
… of the active material and the electrode formulation impact the nano and microstructure of the electrodes and the mechanism of Li insertion. This project addresses the ambiguity in the organic electrode material (OEM) literature, with regards to the composition of reported dicarboxylic …
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Kinematic Chain Monoids for Real-Time Kinodynamic Trajectory Optimization in Legged Robots
… ning framework. In chapter 3 I will present a novel formulation of kinematic chains as monoids, which provides a concise representation of the kinodynamics of the limbs of a walking robot. The proposed approach enables easier and more efficient constraints in trajectory planning optimization …
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convex segmentation and mixed-integer footstep planning for a walking robot
This work presents a novel formulation of the footstep planning problem as a mixed-integer convex optimization. The footstep planning problem involves choosing a set of footstep locations which a walking robot can follow to safely reach a goal through an environment with obstacles. Rather than …
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Constrained Optimization on SO(3), via Pseudospectral Collocation
… geometric consistency. This work introduces a novel formulation of the Legendre–Gauss–Lobatto (LGL) pseudospectral collocation method using a Runge-Kutta-Munthe-Kaas geometric integrator tailored for on-manifold constrained optimization. Constrained Riemannian optimization is carried out via an …
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Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules
The objective of this work was to introduce a novel formulation strategy for intranasal delivery of two low permeation candidates: levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with …
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Bayesian Time Series Learning with Gaussian Processes
… nonlinear state-space models. We present a novel formulation of the GP-SSM that offers new insights into its properties. We then proceed to exploit those insights by developing new learning algorithms for the GP-SSM based on particle Markov chain Monte Carlo and variational inference. …
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A Model-Based Planning and Control Framework for Parkour-Style Legged Locomotion
… guesses through progressively refined problem formulations. Additionally, a novel formulation of rigid-body dynamics algorithms for systems with kinematic loops accelerates trajectory optimization and simulation. Finally, two control strategies are proposed to execute planned motions on …
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Advances in the Use of Finite-Set Statistics for Multitarget Tracking
… density filter. Moreover, we develop a novel method for associating measurements to targets using the Bayes factor, which improves tracking performance for FISST methods as well as other approaches to multitarget tracking. Further, we derive a novel formulation of Bayes risk for use with …
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Locally Administered Particle-Anchored Cytokines Safely Enhance Cancer Immunotherapy
… integrity. Herein, we have developed a novel formulation to anchor potent cytokine molecules to the surface of large-sized particles (1 µm) for local cancer treatment. The cytokines are confined in tumors and have minimal systemic exposure over a few days following intratumoral …
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Vorticity structure and evolution in a transverse jet with new algorithms for scalable particle simulation
… to regularize the formation of small scales. A novel formulation of the vorticity flux boundary conditions rigorously accounts for the interaction of channel vorticity with the jet boundary layer. This formulation yields analytical expressions for vortex lines in near field of the jet and …
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Decoupled Kinodynamic Planning for a Quadruped Robot over Complex Terrain
… popular techniques to develop an advantageous novel motion planning formulation. Our methodology decouples kinematic and dynamic constraints to quickly generate emergent, feasible trajectories for legged systems across complex terrains. We decouple constraints into two separate processes. …
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