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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 39 for “"notch pathway"”.

  1. Anti-Tumor Effects of The Notch Pathway In Gastrointestinal Stromal Tumors

    Dumont, Amaury G2012

    … sufficient to cure patients. The developmental pathway Notch has a critical role in the cell fate, regulating cell proliferation and differentiation. Dysregulation of Notch pathway has been implicated in a wide variety of cancers functioning as a tumor promoter or a tumor suppressor in a cell …

    uthsc Repository record

  2. Mapping of the l(3)DTS4 Gene and Analysis of its Role in the Notch Pathway

    Keating, Jessica2010

    gmu

  3. A Genomic Approach to Identify The Notch Pathway As A Putative Tumor Suppressor In Endometrial Cancer

    Gandhi, Rajshi2013

    … <em>HES1</em>, are down-stream targets of the Notch signaling pathway. <em>HEYL</em> and <em>HES1</em> were identified by microarray and qRT-PCR to have a significant decrease in expression in endometrial carcinomas compared to normal endometrium. We further analyzed the differential expression …

    uthsc Repository record

  4. Investigating the regulation of the Notch pathway ligand Delta-like 1 in the vertebrate segmentation clock

    Bone, RobertUniversity of Dundee2012

    dundee Repository record

  5. The racial disparities of the Gamma-secretase/Notch pathway and inhibition in triple negative breast cancer

    Joseph, Jobin2024

    <p>Triple Negative Breast Cancer (TNBC) continues to be a formidable challenge in oncology, characterized by its aggressive phenotype and limited treatment options. Alarming racial disparities in TNBC outcomes persist, with underrepresented populations experiencing disproportionately higher rates …

    cuny Repository record

  6. Molecular Control of Tooth Mesenchymal Stem Cell Activation

    Walker, Jemma Victoria2019

    … and their progeny, particularly the role of Notch signalling in this process. Methods Isolation of proposed putative MSC containing and known mesenchymal transit amplifying cell (MTAC) containing regions were undertaken. Laser capture microdissection and subsequent comparative analysis of MSC …

    plymouth Repository record

  7. Investigating the genome of Anaplastic Lymphoma Kinase-positive Anaplastic Large Cell Lymphoma

    Larose, HugoUniversity of Cambridge2020

    … Enrichment Analysis. This revealed that the Notch pathway was the most enriched in mutations. In particular, variant T349P of Notch1, which confers a growth advantage to cells in which it is expressed, was detected in 12% of ALK+ and ALK- ALCL patient samples. Furthermore, we demonstrate that …

    cambridge Repository record

  8. The subnuclear localisation of Notch responsive genes

    Jones, Matthew LeslieUniversity of Cambridge2018

    Title: The subnuclear localisation of Notch responsive genes. Candidate Name: Matthew Jones Notch signalling is a highly conserved cell-cell communication pathway with critical roles in metazoan development and mutations in Notch pathway components are implicated in many types of cancer. Notch is …

    cambridge Repository record

  9. Ikkalpha Mediated Notch1 Activation Promotes Tumorigenesis Via Foxa2 Suppression

    Liu, Mo2012

    … expression, and further activates the downstream NOTCH pathway and promotes cell proliferation and tumorigenesis. Moreover, we found that levels of IKKa, pFOXA2 (S107/ 111), and activated NOTCH1 were significantly higher in hepatocellular carcinoma tumors than in normal liver tissues and that …

    uthsc Repository record

  10. EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development

    Webb, Amelia Margaret2021

    … patterning. Lateral inhibition produced by Notch signaling is central to the specification and maintenance of tip and stalk cells in growing angiogenic sprouts. The Notch pathway is activated by the ligand Delta at adherens junctions between tip and stalk cells. Despite the centrality of …

    denver Repository record

  11. The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.

    Eliasz, Sandra2016

    … we focused our research on the role of Notch signaling in cancers of the thorax. Notch-1 signaling has been shown to be required for the growth of SV40-transformed HM. We therefore expanded the studies of the role of Notch signaling in MM and NSCLC. We have found that, under hypoxia, the …

    loyola-thes Repository record

  12. The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord

    Stasiulewicz, MagdalenaUniversity of Dundee2015

    … to adopt a specific neuronal fate.<br/><br/>The Notch pathway plays a crucial role during neurogenesis of both invertebrate and vertebrate embryos. It has also been demonstrated that the Notch and Shh signalling pathways can interplay in various developmental contexts. In this project, I have …

    dundee Repository record

  13. P107 negatively regulates the neural precursor pool by repressing Hes1 transcription

    Wylie, Crystal AUniversity of Ottawa (Canada)2013

    … by examining interactions between p107 and the Notch pathway, which has also been shown to regulate the neural stem cell population (Nakamura et al., 2000; Ohtsuka et al., 2001; Hitoshi et al., 2002b). We found an increase in both the transcript and protein levels of Hes1 in p107-/- brains using …

    ottawa-retro Repository record

  14. Defining the human endothelial transcriptome

    Natarajan, Sripriya, 1978-Massachusetts Institute of Technology2005

    … of the TNFAIP3 family, the KLFfamily and the Notch pathway. Applying these rigorous statistical techniques to genome-wide expression datasets underscores known patterns of endothelial inflammatory gene regulation and unveils new pathways as well.

    mit Repository record

  15. The Tumor Suppressor Notch Inhibits Head and Neck Squamous Cell Carcinoma (Hnscc) Tumor Growth and Progression By Modulating Proto-Oncogenes Axl and Ctnnal1 (Α-Catulin)

    Moorthy, Shhyam2015

    … We were among the first to discover that NOTCH1<em> </em>is one of the most frequently mutated genes in this cancer type. The spectrum of inactivating NOTCH1 mutations in HNSCC suggested a tumor suppressive role for this protein; however, the mechanism of its function is currently …

    uthsc Repository record

  16. Cochlear hair cell regeneration from neonatal mouse supporting cells

    Bramhall, Naomi FMassachusetts Institute of Technology2012

    … regenerative potential. Inhibition of the Notch pathway can stimulate hair cell generation in neonatal mammals, but the specific source of these new hair cells has been unclear. Here, using in vitro lineage tracing with the supporting cell markers Sox2 and Lgr5, we show that Lgr5-positive …

    mit Repository record

  17. Joint Functions of METT-10 and Dynein in the Caenorhabditis elegans Germ Line

    Dorsett, Maia2012

    … to proximal cells and activate intracellular pathways. Activation of such signaling pathways in turn instructs cellular proliferation and differentiation. In the <italic>C.elegans</italic> gonad, GLP-1/Notch signaling instructs germ line stem cells to self renew through mitotic cell division. …

    wustl Repository record

  18. Notchless Interacts with Multiple Signaling Pathways during Mouse Peri-Implantation Development

    Lo, Chiao-Ling

    … and l11Jus4 contain missense mutations in the Notchless homolog 1 (Drosophila) (Nle1) gene. NLE1 is thought to signal via the canonical NOTCH pathway in vertebrates. Although in invertebrates and lower vertebrates, NOTCH signaling directs cell fate prior to gastrulation, it is dispensable for …

    purdue-thes Repository record

  19. FKBP14 in Notch Signalling and Drosophila Development

    Bonner, Julia Maeve2014

    … growing list of transmembrane proteins including Notch and Amyloid Precursor Protein. Autosomal dominant mutations in the genes encoding human PS have been closely linked to cases of early onset familial Alzheimer's Disease (FAD), and these FAD-linked PS mutations influence the activity of …

    toronto-retro Repository record

  20. A study of Notch signalling in developmental angiogenesis

    Phng, L.-K.UCL (University College London)2009

    … regulated. Previous studies have shown that the Notch ligand, Delta-like 4 (Dll4), is prominently expressed in tip cells, therefore suggesting a role of Notch signalling in its regulation. In the mouse, suppression of Notch signalling by pharmacological inhibition of γ-secretase or genetic …

    ucl Repository record

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