Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 512 for “"notch"”.
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Identifying notch-regulated genes using a specific notch signaling inhibitor
… by several signaling pathways, notably the notch signaling pathway. Gamma-secretase, an enzyme crucial for initiating notch signaling, can be inhibited by DAPT. However, DAPT also targets non-Notch substrates, complicating the identification of genes specifically regulated by Notch. To …
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Decoding the Notch signal: investigating dynamics of transcription directed by Notch responsive enhancers
… decoded to generate transcriptional outcomes. Notch is an evolutionarily conserved signalling pathway, which, despite its apparent simplicity, regulates very different processes across tissues and developmental contexts. After activation of the pathway via interaction of the Notch receptor with …
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Notch Signaling in Human Neuroblastoma Cells
… of the SNS. Hash-1 is a component of the Notch signaling cascade, which is involved in many cell fate decisions. In general, Notch activity maintains a pool of undifferentiated cells and dysregulated Notch signaling has been linked to development of several cancers. It has been shown that …
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Kinetics of notch signaling during osteoclastogenesis
… attributed to decreased estrogen levels. The Notch signal pathway is a highly conserved direct cell communication pathway known to regulate cell proliferation, differentiation and survival in many cell types including the differentiation of osteoclasts from bone marrow macrophages (BMMs). …
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FKBP14 in Notch Signalling and Drosophila Development
… growing list of transmembrane proteins including Notch and Amyloid Precursor Protein. Autosomal dominant mutations in the genes encoding human PS have been closely linked to cases of early onset familial Alzheimer's Disease (FAD), and these FAD-linked PS mutations influence the activity of …
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NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM
Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy …
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The subnuclear localisation of Notch responsive genes
Title: The subnuclear localisation of Notch responsive genes. Candidate Name: Matthew Jones Notch signalling is a highly conserved cell-cell communication pathway with critical roles in metazoan development and mutations in Notch pathway components are implicated in many types of cancer. Notch is …
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A study of Notch signalling in developmental angiogenesis
… regulated. Previous studies have shown that the Notch ligand, Delta-like 4 (Dll4), is prominently expressed in tip cells, therefore suggesting a role of Notch signalling in its regulation. In the mouse, suppression of Notch signalling by pharmacological inhibition of γ-secretase or genetic …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor …
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Role of Notch Signaling in T Cell Polarization
… my thesis, I aimed to study the role of Notch cell surface receptors in Th17 differentiation. Using in vitro Th17 differentiation assays of human naïve CD4+ T cells, I have shown that Notch signaling, particularly Notch1, plays a crucial role in Th17 polarization. By using pharmacological …
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Calculation of Notch Strains Under Multiaxial Nominal Loading
… and the anisotropic geometry factors of the notch, and accounts for varying degrees of constrained plastic flow at the stress concentrator. Plastic strain increments at the stress concentrator and anisotropic work-hardening effects are then related to this yield surface using standard methods …
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Section-Size and Notch-Size Effects in Fatigue
Made available in DSpace on 2014-12-12T00:25:53Z (GMT). No. of bitstreams: 1 7317378.pdf: 3467042 bytes, checksum: 1f4ac849cb7ff08297987ce46402d5c7 (MD5) Previous issue date: 1972
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Zebrafish Posterior Lateral Line Organogenesis Regulation by Notch Signaling
… chages. Results in this thesis demonstrate that Notch signaling is an integral part of the feedback loop between Wnt and Fgf signaling that underlies the self‐organization of rosette‐shaped sensory organs in the zebrafish lateral line system. Notch cell autonomously induces apical constriction …
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Transcription and chromatin dynamics in the Notch signalling response
… chromatin environment. The highly-conserved Notch signalling pathway is involved in many cell fate decisions during development, activating different target genes in different contexts. Upon ligand binding, the Notch receptor itself is cleaved, allowing the intracellular domain to travel to …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to mechanical stimuli. VSMC differentiation is a …
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