Global ETD Search
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Showing 1 to 16 of 16 for “"nosocomial pathogen"”.
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The effect of antibiotics on Pseudomonas aeruginosa biofilm production
… resistant species is Pseudomonas aeruginosa, a nosocomial pathogen that produces a biofilm that enhances its resistance. This project examined the possibility of using bacteriocin, an internal protective toxin produced by some species of bacteria, as a potential treatment for resistant bacteria. …
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Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa
Background: Staphylococcus aureus is an important pathogen in paediatric patients with bloodstream infections. The epidemiology of S. aureus bacteraemia (SAB), however, has not been well documented in children in South Africa. Methods: A retrospective study was conducted at a children's hospital in …
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Investigating the Roles of CwlD and GerS in <i>Clostridioides difficile</i> Spore Cortex Modification
Clostridioides difficile is a notable nosocomial pathogen distinguished by its capacity to produce spores, essential for its survival and dissemination. The spore cortex, consisting of a modified peptidoglycan layer, is essential for dormancy and germination. This work examines the enzyme CwlD, …
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The genomic characterization of carbapenemase-producing Serratia marcescens at a tertiary hospital in South Africa
… Serratia marcescens is an opportunistic nosocomial pathogen, and recent reports have highlighted the rapid increase in multidrug resistance in this organism. There is a paucity in genomic data for carbapenem resistant S. marcescens (CRSM). Methods A retrospective cohort study describing …
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Novel collective prey evasion response of Pseudomonas aeruginosa PAO1 to soil micropredator Myxococcus xanthus DK1622
… <em>P. aeruginosa</em> is an opportunistic and nosocomial pathogen responsible for 10% of all hospital acquired infections. <em>P. aeruginosa</em> is also an ESKAPE pathogen, which are leading causes of nosocomial infections throughout the world, and they are often multi-drug resistant. When …
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Functionalization of phage endolysins to treat infections of spore-forming Clostridia bacteria in the era of antibiotic resistance
Certain *Clostridia* species are notable pathogens, not only because they form highly resistant endospores but because they produce toxins and exhibit antibiotic resistance. *Clostridioides difficile* is a nosocomial pathogen responsible for thousands of deaths every year, whereas *Clostridium …
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Environmental bacteriophages infecting Dickeya and Serratia species: receptors and diversity
Phytopathogenic Dickeya species inflict large economic losses on a variety of crops. A lack of effective chemical control methods has generated interest in the use of bacteriophages (phages) as a novel tool for biocontrol. In the last decade, six phages have been isolated in Belgium and Poland …
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Effect of Autoregulated TxeR on the Expression of <I>Clostridium difficile</I> Toxins
Clostridium difficile is a major nosocomial pathogen responsible for causing pseudomembranous colitis. It is estimated that 25% of antibiotic-associated diarrhea is due to C. difficile. These diseases result from intestinal tissue damage caused by two of the largest known bacterial toxins, A and B. …
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Identification of Operons in clostridium difficile
… Gram-positive bacterium, is a major nosocomial pathogen that causes severe, toxin-mediated diarrhea and pseudomembranous colitis. Previous studies of pathogenic bacteria, including C. difficile, have investigated the operon structures and their roles in drug resistance and …
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Molecular Characteristics and Dissemination Mechanism of Vancomycin-Resistant Enterococci: A Tertiary vs. Non-Tertiary Health Care Hospitals
… (VRE) have been endemic in Korea as a nosocomial pathogen. The aim of this study was to examine genetic relatedness and dissemination mechanism by comparative analysis of the antimicrobial and biomolecular characteristics of VRE isolates from tertiary and non-tertiary health care …
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Diversity of acinetobacter baumannii isolates from Egypt
Acinetobacter baumannii is an important nosocomial pathogen, frequently associated with morbidity and mortality in immunocompromised patients due to the immuno-ablative treatments, neutropenia and prolonged hospitalization. The ability of A. baumannii to survive in the healthcare setting makes it a …
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Identification of methicillin-resistant Staphylococcus aureus in horses using conventional and molecular techniques
… Staphylococcus aureus or MRSA is an important nosocomial pathogen in both humans and animals due to its resistance to all ?-lactam antimicrobial agents. Colonization of MRSA in horses poses a great concern. This is considered an important risk factor for development of staphylococcal related …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… MDR) which makes it a highly troublesome pathogen in many hospitals around the world. Third-generation cephalosporins (such as ceftazidime) and carbapenems (such as imipenem and meropenem) represent important treatment options for infections caused by this microorganism. Nevertheless, the …
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Evolutionary Genomics of Cystic Fibrosis and Nosocomial Pathogens of the Mycobacterium abscessus species complex
… the MABSC has evolved to become an opportunistic pathogen, which in turn could potentially uncover promising targets for the development of novel antibiotics. Genomic analysis of the MABSC has already shown that lineages of the MABSC are capable of indirect person to person transmission and the …
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Studying the riboregulatory role of Hfq in Klebsiella pneumoniae using CLASH (crosslinking, ligation and sequencing of hybrids)
… I investigated Hfq, an RBP in a Gram-negative nosocomial pathogen Klebsiella pneumoniae (Kp), using a high-throughput sequencing technique named CLASH (Crosslinking, ligation, and sequencing of hybrids). I performed CLASH in two Kp strains - Ecl8 and Ecl8ΔramR (RamA overexpressor), and …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… Staphylococcus aureus (MRSA) is an important nosocomial pathogen associated with significant morbidity and mortality. Previous colonisation with this pathogen is a risk factor for the development of subsequent infection. Tolllike receptors (TLRs) are a family of transmembrane receptors of the …