Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"normal tissue toxicity"”.
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Effects of Advanced Radiotherapy techniques on Normal Tissue Toxicity in Breast Cancer
… with some long-term side effects and breast tissue toxicities including breast shrinkage, breast fibrosis, skin changes and poor overall cosmesis. These breast-specific complications can have a detrimental psychological impact. New radiotherapy techniques including IMRT and IGRT have the …
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Improving The Accuracy of Radiation Pneumonitis Dose Response Models
… However, dose to lung tumor is limited by normal tissue toxicity. The most prevalent thoracic toxicity is radiation pneumonitis. In order to determine a safe dose that can be delivered to the healthy lung, researchers have turned to mathematical models predicting the rate of radiation …
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Enhancing the radio sensitivity of prostate cancer using RALA Gold nano-complexes
… Many patients respond well to RT, however, normal tissue toxicity limits clinical potential. In PCa there is a distinct therapeutic window between normal and malignant tissue, providing an opportunity to exploit for therapeutic gain. This thesis explored ways to improve the use of RT through …
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Integration of Biomedical Imaging and Translational Approaches For Management of Head and Neck Cancer
… and characterization of patterns of failure and normal tissue toxicity in head and neck cancer (HNC) patients with potentially curable tumors. In Aim 1, we showed that the currently available clinical imaging modalities can be successfully used to adapt RT dose based-on dynamic tumor response, …
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Improving the Efficacy and Expanding the Application of NQO1-Bioactivated Therapeutics
… lower, well-tolerated doses without increasing normal tissue toxicity. Targeting the NAD+ synthesis pathway by inhibiting NAMPT prevented cells from surviving the metabolic stress of NAD+ and ATP depletion induced by PARP1 hyperactivation secondary to ß-lap treatment. This resulted in …
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A Monte Carlo-based Model Of Gold Nanoparticle Radiosensitization
… locoregional tumour control, while minimizing normal tissue toxicity. A greater therapeutic ratio can be achieved by utilizing radiosensitizing agents designed to enhance the effects of radiation at the tumour. Gold nanoparticles (AuNP) represent a novel radiosensitizer with unique and …
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Utilizing Computed to mography Image Features to Advance Prediction of Radiation Pneumonitis
… balance between local tumor control and risk of normal tissue toxicity. In approximately 20% of patients, severe acute symptomatic lung toxicity, termed radiation pneumonitis (RP), still occurs. Identifying the individuals at risk of RP prior to or early during treatment offers tremendous …
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Car-Modified T Cells Capable of Distinguishing Normal Cells From Malignant Cells
… cells. Due to the potential for on-target, off-tissue toxicity, CAR<sup>+</sup> T-cell therapy is currently limited to unique or lineage-restricted TAAs. Glioblastoma, a grade IV brain malignancy, overexpresses epidermal growth factor receptor (EGFR) in 40-50% of patients. EGFR also has …
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
… (NSCLC). Radiation esophagitis is an acute normal tissue toxicity that negatively affects treatment efficacy by limiting dose and potentially interrupting radiation therapy. Clinical quantification of this toxicity is typically achieved by utilizing physician grading scales, assigning …
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Characterization of brain response following cranial radiotherapy
Cranial radiotherapy (CRT) is a vital component for the treatment of pediatric brain tumors, with combination therapy that includes CRT resulting in almost 90\% five-year survival. However, survivors treated with CRT exhibit alterations in brain development and long-term deficits in brain structure …
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Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
… chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumor. Relying on the EPR effect (Enhanced Permeability and Retention), a host of nanoparticles (from micelles and dendrimers to liposomes and lipidic nanoparticles) have been developed and …
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Facilitating the Clinical Translation of Flash Radiotherapy Through Dosimetry Development and Beam Parameter Optimization
… curing disease while minimizing any associated normal-tissue complications<sup>1</sup>. Recently, ultra-high dose-rate (UHDR) RT (mean dose rates ≥40 Gy/s for a total duration of ≤200 ms) has been reported to selectively spare normal tissues and organs while maintaining an isoeffective …
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Enhancing Cisplatin Delivery and Anti-tumor Efficacy Using Hyperthermia
… including cisplatin, resulting in increased cytotoxicity. In addition to these biological responses, hyperthermia can be used as a drug-release trigger for temperature-sensitive nanoparticles, resulting in an improved and more targeted drug delivery system. Cisplatin was chosen because 1) it …