Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"normal tissue damage"”.
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4D Study of Thoracic Cancer Radiation Treatment
… thoracic malignancies due to an increase in the normal tissue irradiated and an uncertainty in the radiation coverage of the tumor. This results in a potential increase in complications from treatment and may be insufficient to ensure coverage of the tumor. Reduction of the volume of normal …
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A Comparison of Two 'In Vitro' Assays to Assess Radiosensitivity in Patients Receiving Radiotherapy
This thesis addresses the occurrence of normal tissue damage as a limiting factor in curative radiotherapy and the need for predictive radiosensitivity testing. Patients who display unusual sensitivity to radiation may also exhibit a poor DNA repair capacity. Consequently, in vitro assays which …
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Assessing The Potential Clinical Impact of Variable Biological Effectiveness In Proton Radiotherapy
… This arises from the clustered nature of DNA damage produced by the energy deposition of protons along their tracks in medium. This effect is currently quantified in clinical settings by assigning protons a relative biological effectiveness (RBE) value of 1.1 corresponding to 10% increased …
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Analysis of Minocycline as a Radioprotectant
… nervous system (CNS), but includes the risk for normal tissue damage, often leading to cognitive impairment. The literature suggests that tetracyclines can be radioprotectors of the hematopoietic system with potential utility in radiation emergencies and anticancer radiotherapy. Minocycline, a …
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Ionizing Radiation and Endostatin Gene Therapy Against Lung Tumor
… made in radiotherapy, tumor radioresistance and normal tissue damage continue to always be important issues for radiation oncologists. Numerous reports have also documented that radiation exposure increases the risk for malignancy and suppresses immune mechanisms. However, increasing evidence has …
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An Exploration of the Feasibility of Combining Radiation Therapy with Psoralen Phototherapy
… beam delivery within the target volume to reduce normal tissue damage typically expected of kV beams was demonstrated with a 3D-printing-based preclinical irradiation scheme, which is expected to help X-PACT translation into the clinics. In addition, for X-PACT, novel MV-responding phosphors were …
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Immunospecific albumin microspheres as a drug delivery system for cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma
… tumour cell kill whilst sparing surrounding normal tissue and substantially reducing side-effects. This project examined the possible therapeutic role of a targetable sustained drug delivery system, albumin immunomicrospheres containing the chemotherapeutic agents, cisplatin and …
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Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
… proteomic effects of 131I and 211At exposure on normal thyroid tissue in vivo. The influence of absorbed dose, dose-rate, time after administration, and radiation quality on gene expression regulation was studied. Another aim was to identify radiation-responsive genes in thyroid. Mice and rats …