Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"normal tissue complication probability"”.
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Temporally Feathered Radiation Therapy under Uncertainty
… dose intensities and rest periods based on tissue-specific recovery potential. The model incorporates inter-organ variability using the linear-quadratic model within a dynamic normal tissue complication probability framework, allowing for tailored protection of sensitive tissues without …
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Towards patient selection for cranial proton beam therapy – Assessment of current patient-individual treatment decision strategies
… advantages in terms of sparing healthy tissue compared to conventional photon radiotherapy. Those patients who are supposed to experience the greatest reduction in side effects should preferably be treated with proton beam therapy. One option for this patient selection is the model-based …
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Utilizing Computed to mography Image Features to Advance Prediction of Radiation Pneumonitis
… balance between local tumor control and risk of normal tissue toxicity. In approximately 20% of patients, severe acute symptomatic lung toxicity, termed radiation pneumonitis (RP), still occurs. Identifying the individuals at risk of RP prior to or early during treatment offers tremendous …
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Head and Neck Cancer Offline Adaptive Radiotherapy Proof-of-Concept Workflow for Low-Resource Clinics Utilizing NTCP
… assessment scheme, but instead utilizing normal tissue complication probability (NTCP) metrics. NTCP values were retrospectively calculated and compared between the planned dose and true delivered dose. Adaptive replanning was deemed warranted for a patient plan if the change in NTCP …
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Towards Offline Adaptive Therapy for Prostate Patients using Velocity
… dose (fractional dose differences up to 94%) and normal tissue complication probability (NTCP), with improved agreement using SGD. The first patient’s bladder tended to be extremely over-filled, with day-of-treatment volume up to 548% simulation volume. Due to the large volume difference, poor …
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Effects of Advanced Radiotherapy techniques on Normal Tissue Toxicity in Breast Cancer
… with some long-term side effects and breast tissue toxicities including breast shrinkage, breast fibrosis, skin changes and poor overall cosmesis. These breast-specific complications can have a detrimental psychological impact. New radiotherapy techniques including IMRT and IGRT have the …
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Beyond The Dvh - Spatial And Biological Radiotherapy Treatment Planning
… due to cell migration, bystander effect, and tissue motion during treatment. Further, the concept of Spatial DVH (sDVH) is introduced to evaluate and potentially optimize the spatial dose distribution in the target volume. Finally, generalized equivalent uniform dose is derived from both …
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Quality Assurance of Advanced Treatment Modalities Using Presage® Dosimeters
… 2D measurements resulting in a 5% change in the normal tissue complication probability (NTCP). An optical CT scanner was tested for reproducibility and reliability and a standard operating procedure was created. The PRESAGE<sup>®</sup> dosimeters were extensively tested for dose stability over a …
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Quantifying, Understanding and Predicting Differences Between Planned and Delivered Dose to Organs at Risk in Head & Neck Cancer Patients Undergoing Radical Radiotherapy to Promote Intelligently Targeted Adaptive Radiotherapy
… with univariate, and logistic regression normal tissue complication probability (NTCP) modelling approaches. A sub-study of VoxTox recruited 18 patients who had MRI scans before RT fractions 1, 6, 16, and 26. Changes in salivary gland volumes and relative apparent diffusion coefficient …
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The Development of Artificial Intelligence-Based to ols For Expert Peer Review of Radiotherapy Treatment Plans
… clinical objectives of tumor coverage and normal tissue sparing. Often, a plan is selected because it meets basic organ at risk dose thresholds for severe toxicity; however, it is evident that a plan with a decreased risk of normal tissue complication probability could be achieved. This …
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Improving Dose-Response Correlations For Locally Advanced Nsclc Patients Treated With Imrt Or Pspt
… RP representation. These models represent lung tissue damage with radiation dose distribution planned pre-treatment, which assumes a fixed patient geometry and inevitably renders imprecise dose delivery due to intra-fractional breathing motion and inter-fractional anatomy response. Additionally, …
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Accumulating delivered dose to the rectum to improve toxicity prediction in prostate radiotherapy
… to minimise the risk of toxicity. Current normal tissue complication probability (NTCP) models are based on planned dose data and do not consider the effects of organ motion on true delivered dose. The VoxTox research programme has developed automated solutions for segmentation and dose …
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Quantitative Comparison of Late Effects Following Photon Versus Proton External-Beam Radiation Therapies: to ward An Evidence-Based Approach to Selecting A Treatment Modality
… to develop strategies to minimize radiogenic complications, one must first quantitatively estimate pediatric patients’ relative risk for radiogenic late effects, which has not become feasible till recently because of the calculational complexity. The goals of this work were to calculate the …
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Radiation biophysical modeling of the FLASH effect: from mechanistic understanding towards clinical endpoint prediction
… allows to obtain reduced side effects for normal tissue, for example, with reported evidence of a decrease in memory loss or less intestine necrosis, and, at the same time, the same effectiveness on tumor control, e.g., an indistinguishable tumor response for HBCx-12A xenografts. This FLASH …