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Showing 1 to 2 of 2 for “"norcoclaurine synthase"”.
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Biosynthesis of tetrahydroisoquinoline scaffolds in yeast
… tetrahydroisoquinoline alkaloid precursor (S)-norcoclaurine via a combination of yeast Ehrlich pathway metabolism of ʟ-tyrosine and expression of norcoclaurine synthase with a dopamine production pathway. Building on this, I developed a retrosynthetic framework to produce phenylisoquinoline, …
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Crystallization studies of Pictet-Spenglerases
… alkaloid biosynthesis, the enzyme strictosidine synthase catalyzes the first committed reaction. This reaction is a Pictet-Spengler coupling between tryptamine and secologanin and produces the biosynthetic intermediate strictosidine, common to all monoterpene indole alkaloids. To better …