Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"nonsteroidal anti-inflammatory"”.
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Monitoring Dissolution of Nonsteroidal Anti-Inflammatory Drugs Using Infrared Spectroscopy
<p>A comparison study was conducted to look at the formulation of three brands of naproxen sodium. These brands included Bayer Aleve ®, CVS All Day Pain Relief and Walgreens All Day Pain Relief. The active and inactive ingredients were the same yet the size and shape of the tablets differ among the …
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The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… angiotensin II, and vasopressin. Nonsteroidal anti-inflammatory drugs (NSAIDs) produce both their beneficial and detrimental effects through inhibition of the cyclooxygenase enzyme and subsequent interference with prostaglandin production. Healthy canine kidneys express both COX-1 …
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Nonsteroidal anti-inflammatory drugs and prostaglandin synthesis inhibitors in the treatment of urinary diseases and their effects on renal functions: clinical studies
… pressure, lower urethral pressure and inhibit antidiuretic hormone. We hypothesized that high production of prostaglandins or their dominant action on the urinary system may play a role in the pathogenesis of primary enuresis and nocturnal frequency of micturition. To test this, inhibition of …
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Evaluation of the toxic effects of eltenac (4-((2,6-dichlorophenyl) amino)-3-thiophene acetic acid), a nonsteroidal anti-inflammatory drug, in horses
… determine the potential toxic effects of the new nonsteroidal anti-inflammatory drug, eltenac (4-[(2,6-dichlorophenyl) amino]-3-thiopheneacetic acid), in horses. Four treatment groups were formed, each composed of 6 horses. The drug was injected intravenously, once daily, at a dose rate of 0.5 …
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The Association of Celecoxib, Rofecoxib, and Non-selective NSAIDs with Indices of Thrombosis and Endothelial Function in the Multi-Ethnic Study of Atherosclerosis
… (COX-2) inhibitors and non-selective nonsteroidal anti-inflammatory medications (NSAIDs) have been associated with increased cardiovascular risk. It is the intent of this discussion to explore mechanisms by which celecoxib, rofecoxib, and nonselective anti-inflammatory medications …
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Alterações morfológicas promovidas pelo uso de anti-inflamatórios não-esteroidais.
… , and the facility of buying /sale of drugs. The nonsteroidal anti - inflammatory (NSAID) therapeutic class occupies frequently the ranking of more utilized drugs in the automedication practice , and it do n o t put out of order when speak s about t he adverse reactions’ development during its …
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Role of Endogenous Prostaglandins on Kainic Acid Induced Seizure Activity
… the epileptic seizure. Pretreatments with NSAID(nonsteroidal anti-inflammatory drug) including COX-2 inhibitors such as indomethacin, nimesulide and celecoxib is known to aggravate the kainic acid(KA)-induced seizure activity. However it is not known whether the pro-conversant effect of NSAID was …
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Die Leukotrienrezeptoren CysLTR1 und CysLTR2 bei Aspirin-Intoleranz
… Important is that a cross reaction to other nonsteroidal anti-inflammatory drugs (NSAID) is possible. The pathogenesis is not sufficient cleared. Aspirin’s target is to inhibit the cyclooxygenase. This leads to a decrease in the level of prostaglandin biosynthesis. The arachidonic acid is …
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The effects of topical diclofenac, flurbiprofen, and ketorolac on corneal sensitivity in normal cats
… to reduce ocular inflammation and nonsteroidal anti-inflammatory drugs (NSAIDs) to control clinical signs associated with ocular pain. Although topical NSAIDs are commonly used in the treatment of a variety of surface ocular diseases, studies demonstrating the effects of topically …
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Molecular interactions in pharmaceutical preformulation and supramolecular complexes. Structural properties governing drug-plasma protein binding and investigation of amino acids co-crystals
… the effect of ionised species on PPB has been quantitatively evaluated. In addition, the molecular interactions also play a key role in the supramolecular complexes of co-crystals. The project also evaluated the co-crystallisation process and its effect on physicochemical properties of the drug. …
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Molecular interactions in pharmaceutical preformulation and supramolecular complexes. Structural properties governing drug-plasma protein binding and investigation of amino acids co-crystals
… the effect of ionised species on PPB has been quantitatively evaluated. In addition, the molecular interactions also play a key role in the supramolecular complexes of co-crystals. The project also evaluated the co-crystallisation process and its effect on physicochemical properties of the drug. …
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Effects of chronic exposure to ibuprofen and naproxen on Florida flagfish (Jordanella floridae) over one complete life-cycle
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs prescribed to relieve pain, fever and inflammation, and are among the most commonly consumed medications in Ontario. Approximately 70% of the ingested dose is excreted unchanged or as an active metabolite, much of which reaches the …
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Concomitant Suppression Of Both Cox-1 And Cox-2 Is Not Sufficient To Cause Gastroenteropathy Associated With Chronic Nsaid Use
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used nonaddictive medications for the management of chronic pain and inflammation; however, these drugs are associated with many gastrointestinal and cardiovascular adverse events, including intestinal bleeding, ulceration, stenosis, …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… et al, 2014). The CXB-NE nanoemulsion carrying a Nonsteroidal Anti-inflammatory (NSAID) inhibitor of COX-2 activity result in a reduction in PGE2 expression in macrophages. Using CXB-NE in rats that have peripheral nerve injury constricting the sciatic nerve relieves hypersensitivity, a pain-like …
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Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows
… to gain a competitive advantage, such as doping. Antidoping regulation in the livestock show industry often involves drug testing. Detection of therapeutic drugs at very low concentrations in approved animal species raises questions about current anti-doping regulations in exhibition animals. …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… in the onset of Alzheimer’s in subjects using nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit enzymes in the cyclooxygenase-2 (COX-2) pathway which play a key role in synthesising prostaglandin E2 (PGE2) from arachidonic acid. PGE2 has been implicated in preclinical stages of …
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The Pharmacokinetics of Firocoxib after Multiple Oral Doses to Neonatal Foals
… Foals are more sensitive to the side effects of nonsteroidal anti-inflammatory drugs, (NSAIDs), particularly due to immature renal clearance mechanisms and ulcerogenic effects on gastric mucosa. Firocoxib, a novel second generation NSAID, is reported to have reduced side effects due to its COX-2 …
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Aqueous humor concentration and prostaglandin E2 suppression efficacy of topically applied ophthalmic ketorolac 0.5% and diclofenac 0.1% solutions in dogs with cataract
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, anti-pyretic and anti-inflammatory properties in both human and veterinary patients. Topical ophthalmic NSAIDs are commonly employed in the management of intraocular inflammation (uveitis), …
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Heme Oxygenase-2 as a novel target to treat inflammation and chronic neuropathic pain associated with corneal injury and surgery
… removal (first step of refractive surgery) an inflammatory response arises and corneal subbasal nerve density does not recover for up to five years. Furthermore, the number of stromal nerves decreases by nearly 90% after LASIK leading to possible complications. One of the most notable adverse …
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Self-Reported Antenatal Medicines Use Among Women Living with and Without HIV in Western Cape, South Africa: A Sub-Analysis of the B Positive Cohort Study
… non-significant within this sample. Excluding antiretroviral medicines, prescription medicine use was essentially the same among pregnant women living with and without HIV (30.5% vs 30.2%, p=0.96). Exposure to medicines known to be potentially teratogenic or unsafe in pregnancy was reported in …
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