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Showing 1 to 2 of 2 for “"nonribosomal peptide synthetases"”.
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Reengineering and Discovery of Nonribosomal Peptide Synthetases
Nonribosomal peptides are an important class of natural products including the life-saving antibiotics penicillin and vancomycin and the deadly microcystins and cereulide. This important category of natural products is thus a focus of many research labs around the world, including the Kelleher lab. …
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Functional Analysis of Secondary Metabolite Biosynthesis-Related Genes in Alternaria brassicicola
… contribute to pathogenicity, we identified seven nonribosomal peptide synthetases (NPSs) and 10 polyketide synthases (PKSs) in the A. brassicicola genome. The phenotype resulting from knockout mutations of each PKS and NPS gene was investigated with an emphasis on discovery of fungal virulence …