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Showing 1 to 3 of 3 for “"nonlinear mixed effects modeling"”.

  1. Challenges in the Pharmacokinetics of Therapeutic Proteins

    … through this pathway will reach its maximum and nonlinear pharmacokinetics will be observed upon further increasing dose if TMDD is a major elimination process. This, in turn, will impact the bioavailability estimation. Bioavailability estimations based on the classic AUC approach can be …

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  2. Population Pharmacokinetics of Therapeutic Monoclonal Antibodies: Examples and Estimation Method Performance Differences

    … of my dissertation research was population PK modeling of therapeutic mAbs, which focused on the population PK modeling of cetuximab, and the evaluation of different estimation methods for population PK modeling of therapeutic mAbs with nonlinear PK characteristics.</p> <p> Cetuximab is a …

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