Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 419 for “"noninvasive"”.
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Noninvasive assessment of cardiovascular health
Cardiovascular health is currently assessed by a collection of hemodynamic parameters many of which can only be measured by invasive methods often requiring hospitalization. A non-invasive approach of evaluating some of these parameters, such as systemic vascular resistance (SVR), maximum left …
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Towards brain-wide noninvasive molecular imaging
… We have therefore implemented a means to permit noninvasive delivery of imaging agents following ultrasonic BBB opening. We use the ultrasound technique to deliver another potent class of contrast agents, superparamagnetic iron oxides, and we show that effective permeation of brain tissue is …
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Accurate noninvasive monitoring of fetal tissue oxygenation level
… mother. To address this concern, we present a noninvasive method for precise fetal oxygenation level monitoring using time-of-flight near-Infrared Spectroscopy (ToF-NIRS). Our method is the first to achieve accurate, multichannel signal separation from two distinct layers. We conducted Monte …
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Noninvasive Temperature Measurements Using Electron Paramagnetic Resonance Spectroscopy
A system has been developed that may be used for non-invasive in vivo temperature measurements in living systems. We use the nitroxide, 3-doxyl-5$\alpha$-cholestane, mixed in 1 mol% cholesterol and 99 mol% methyl docosanoate and encapsulated in proteinaceous microspheres (average diameter $<$2 …
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Ultrasound-based Noninvasive Monitoring Methods for Neurocritical Care
… we developed a set of ultrasound-based noninvasive methods for real-time extra- and transcranial volumetric blood flow measurement and for embolus detection and embolic load quantification. The blood flow waveform measurements were also used to determine intracranial pressure (ICP), …
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Noninvasive disease diagnostics using engineered synthetic urinary biomarkers
… sought to improve these tools by enabling the noninvasive quantification of disease-associated protease activity, deskilling complex diagnostic procedures, and developing a pipeline for extending these tools to additional diseases. Drawing inspiration from existing diagnostics, we modified our …
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Noninvasive ultrasound techniques for assessment of early atherosclerosis
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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Validation of a Noninvasive Blood Perfusion Measurement Sensor
… step in the ongoing development of a system to noninvasively estimate blood perfusion using thermal methods. A combination thermocouple/thermopile sensor records heat flux and temperature measurements on the tissue of interest (in this case skin) for a given period of time. These data, in …
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A noninvasive, image-based smartphone app for diagnosing anemia
… using smartphone-based algorithms to enable a noninvasive, accurate, and accessible anemia diagnostic. Here, a patient simply takes a picture of their fingernail beds using their smartphone, and the image analysis algorithm analyzes color data and image metadata to measure the corresponding Hgb …
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Using Pressure Transducers for Noninvasive Heart and Respiratory Monitoring
Detecting heart and respiratory rates is an essential means of providing emergency medical care. Current methods of detecting such signals include the widely used electrocardiography (ECG) method. Other more manual methods of heart and respiratory rate estimation require a practitioner to …
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Investigation of biomarkers for noninvasive early diagnosis of cancer
<p>"Cancer is the second leading cause of death worldwide, and deaths from cancer worldwide are projected to continue rising, with an estimated 12 million deaths in 2030. Cancer occurs when cells in a part of the body begin to grow out of control. It develops very rapidly, and early diagnosis …
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Hydrodynamic Characterization of 3D Fluidized Beds Using Noninvasive Techniques
… consuming. X-ray computed tomography (CT), as a noninvasive technique, can quantify local time-average phase fractions in highly dynamic multiphase systems without disturbing local structure.</p> <p>Using X-ray visualization techniques, methods have been developed in this study to: 1) test the …
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Methods and devices for noninvasive physiologic fluid volume assessment
… individuals and clinicians of fluid status in a noninvasive, rapid, and reliable manner. Drawing on the molecular sensitivity of IH nuclear magnetic resonance (NMR), we explored the ability of NMR methods to quantitate physiologic fluid volume changes. We first proved that NMR methods could …
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Noninvasive optical inhibition with a red-shifted microbial rhodopsin
… of neurons deep in the brains of awake mice. The noninvasive optogenetic inhibition opened up by Jaws enables a variety of important neuroscience experiments, and offers a powerful general-use chloride pump for basic and applied neuroscience.
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Sparking controversy : the contested use of noninvasive brain stimulation
… direct current stimulation (tDCS), a noninvasive form of brain stimulation that is thought to provide a constant low level of electrical current to the brain. Although scientists have been experimenting with tDCS in both healthy and clinical populations for the last fifteen years, in …
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A spectral approach for noninvasive estimation of intracranial pressure
… to critically ill patients. An accurate noninvasive method to estimate ICP would dramatically expand the patient pool for which this important cranial vital sign becomes available. This work expands upon a model-based spectral approach to estimate ICP from arterial blood pressure (ABP) …
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Noninvasive optoacoustic monitoring of blood oxygenation in large blood vessels
… blood oxygenation are invasive. We propose the noninvasive monitoring of cerebral venous blood hemoglobin saturation (SvO2) by optoacoustic probing of blood circulating in the internal jugular vein (IJV). This thesis describes the tests of the optoacoustic system with three different probes in …
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Development of Quantitative Molecular Photoacoustic Imaging For Noninvasive Cancer Diagnostics
… PA imaging techniques were developed for noninvasive, quantitative visualization of two biomarkers: SO<sub>2</sub>, via imaging of oxy- and deoxyhemoglobin; and cell receptor expression, via imaging of a novel contrast agent, liposome-encapsulated J-aggregated indocyanine green …
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
… The advantage of using this approach lies in its noninvasive sampling characteristics and robust analytical feasibility. The dissertation begins with the development of two analytical methods for the determination of sarcosine in urine for the early detection of prostate cancer. The next three …
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