Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"nongenomic"”.
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Nongenomic Effects of Estrogens on Epithelial Chloride Secretion.
… secretagogues. This effect may be due to nongenomic actions of 17β-E2 on CFTR function and/or the activity of store-operated calcium channels, which leads to a change in CFTR functional regulation.</p>
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Characterization of Rapid Nongenomic Cortisol Signalling in Rainbow Trout Liver
… exerts physiological effects through genomic and nongenomic signalling pathways. The genomic response to cortisol is characterized by activation of the corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), whereas the nongenomic cortisol response involves …
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… (DAT). In this dissertation we tested the rapid nongenomic effects of several physiological estrogens [estradiol (E2) estrone (E1), and estriol (E3)] and xenoestrogens (XEs), such as organochlorine pesticides [dieldrin, endosulfan, and o¡¯,p¡¯-dichlorodiphenylethylene (DDE)], plastics …
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Membrane mechanism of progesterone actions on the rat brain
… least three lines of evidence indicating that a nongenomic mechanism of P's action is also involved. First, P exerts effects on tissue preparations without genomic apparatus. Second, P's effects are insensitive to protein biosynthesis inhibitors. Finally, responses of P's actions on the CNS are …
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EGFR Signaling Is Necessary for Gonadotropin-Induced Steroidogenesis and Oocyte Maturation
… work focused on transcriptionindependent, or nongenomic, steroid-induced maturation of oocytes. We demonstrated for the first time that steroids trigger oocyte maturation in several different mouse models, activating G protein signaling, as well as MAPK and CDK1/cdc2 intracellular signaling …
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Chemical Mixtures of Xenoestrogens and Their Metabolites Alter Estradiol-Induced Non-Genomic Signaling
… line, to characterize the potentially potent nongenomic signaling and functional responses to these compounds alone, as mixtures, as metabolites and congeners, and in combination with estradiol (E2), while also automating these assays to facilitate future screening of a potentially large …
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Effect of Estradiol on xc- in Human Breast Cancer Cells
… that this downregulation of xCT may be due to nongenomic action of the estradiol bound membrane associated ER and activation of protein kinase signaling cascades.</p>
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Use of estradiol-BSA conjugates to characterize membrane estrogen binding sites in brain cells: Biochemical and physiological studies
Rapid nongenomic actions of estrogen probably involve one or several membrane estrogen receptors/binding proteins, which are different from classical estrogen receptor (ER). Specific membrane binding sites for estrogen (mEBS) in female rat brain were demonstrated by a novel and sensitive …
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The Influence of Estrogen Signaling on Male Reproduction in Medaka (Oryzias latipes)
… through both classic genomic signaling and nongenomic signaling. Furthermore, the importance of estrogen signaling in normal male reproduction is just beginning to be understood. The primary goal of this dissertation was to assess the implications of aberrant estrogen signaling on male …
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Estrogen Signaling in Trigeminal Nociception
… estrogen can occur through both `genomic' and `nongenomic' pathways. The novel estrogen receptor GPR30 (G-protein coupled receptor 30) activates mediators of signal transduction, including ERK. A goal of this study was to determine which estrogen receptor is required for behavioral …