Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 53 for “"noncoding RNAs"”.
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Genome regulation by long noncoding RNAs
… also produce thousands of long non-coding RNAs (lncRNAs), some of which are now known to play essential roles in diverse biological processes including cellular differentiation and human disease. Recent studies show that many lncRNAs localize to the nucleus and interact with chromatin …
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Comparative transcriptomics of long intergenic noncoding RNAs in Drosophila
… of the amino acid code, long intergenic noncoding RNAs (lincRNAs) can be expected to evolve along different trajectories than protein-coding genes. Most studies of lincRNA evolution analyze evolution only at the sequence level without ascertaining whether the lincRNA is expressed. Over …
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The Modulation of Innate Immunity by Cellular and Viral Noncoding RNAs
… that endogenous and viral non-coding RNAs possess the ability to alter innate immunity and inflammatory responses. For example, endogenous non-coding RNAs can be recognized by pattern recognition receptors to trigger innate immune activation and inflammation. Many positive sense RNA …
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MEF2-regulated Gtl2-Dio3 noncoding RNAs in cardiac muscle and disease
… expression analysis of selected Gtl2-Dio3 microRNAs revealed high enrichment in cardiac muscle. Therefore, I investigated the role of selected microRNAs from the Gtl2-Dio3 noncoding RNA locus in the heart. First, I found that Gtl2-Dio3 microRNAs are expressed at higher levels in perinatal hearts …
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Determining the Roles that DICER1 and Noncoding RNAs Play in Endometrial Tumorigenesis
… thesis work I sought to determine the role that noncoding RNAs play in endometrial tumorigenesis. Aberrant methylation of the promoter region of the MLH1 DNA mismatch repair gene in endometrial cancer is associated with loss of MLH1 expression and a "mutator phenotype" in endometrial and other …
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Discovery and analysis of long noncoding RNAs in gene expression control and cell cycle progression
… transcripts are classified as long non-coding RNAs (lncRNAs), with size larger than 200 nucleotides, but very few have been functionally characterized. Here, I detail a journey of the discovery and analysis of lncRNAs in gene expression control and cell cycle progression, beginning from the …
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Enabling the in vitro study of long noncoding RNAs to understand their role in Plasmodium falciparum
Long noncoding RNAs (lncRNAs) have been identified in *Plasmodium falciparum*, the parasitic cause for life-threatening malaria, yet their role remains largely undiscovered. Through interactions with nucleic acids and proteins, lncRNAs can modulate gene expression at the transcriptional, …
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Systematic Identification of Independent Functional Non-coding RNA Genes in Oxytricha trifallax
Functional noncoding RNAs participate in a variety of biological processes: for example, modulating translation, catalyzing biochemical reactions, sensing environments etc. Independent of conventional approaches such as transcriptomics and computational comparative analysis, we took advantage of …
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Evolutionary signatures for unearthing functional elements in the human transcriptome
… evolution to evaluate the conservation of long noncoding RNAs. These metrics further reveal that long noncoding RNAs harbor distinct evolutionary signatures, suggesting that they are not a homogenous class of molecules but rather a mixture of multiple functional classes with distinct biological …
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Small RNAs Regulate Transcription by Interacting with Noncoding RNA Transcripts
… dependent manner. The mechanism by which RNAs achieve promoter recognition has remained unclear. Sequence specific recognition could be achieved by (1) RNA hybridization to genomic DNA, or (2) RNA recognition of some uncharacterized RNA species. Promoter targeted duplex RNA has been shown …
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The Regulation and Evolution of long, noncoding RNA Transcription
… leading to the production of thousands of long, noncoding RNAs (lncRNAs, > 200 basepairs), which are distinct from more traditional noncoding RNAs such as transfer RNAs or ribosomal RNAs. This striking finding is observed across all eukaryotes, from humans to budding yeast. It was once thought …
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The regulation of premature termination at divergent promoters
… producing low-abundant upstream antisense RNAs (uaRNAs) in addition to a stable downstream RNAs. Thus, a central question is what mechanisms are sense RNAs more stable compared to most transcription events. It is proposed that an asymmetric distribution of Ul snRNP binding sites and …
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Functional miRNA regulation of metastatic genes promotes tumor cell dissemination in non-small cell and small cell lung carcinomas
… in the last decade, emphasis on the role of noncoding RNAs in post-transcriptional modifications has revealed their important contribution in the regulation of developmental programs across metazoan species. More recently, the role of alterations in expression of small noncoding RNAs, …
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The Role of the Human Nuclear Poly(A) Binding Protein in RNA Decay
… required for the degradation of a viral nuclear noncoding RNA as well as an inefficiently exported human mRNA. Importantly, the targeting of RNAs to this decay pathway requires the PABPN1 and poly(A) polymerase (PAP)-dependent extension of the poly(A) tail. Nuclear transcripts with longer poly(A) …
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Non-coding RNA networks regulating leaf vegetative desiccation tolerance in the resurrection plant Xerophyta humilis.
… is known with regards to the role of regulatory noncoding RNAs (ncRNAs). To investigate the presence and roles of possible ncRNA players, RNA-Seq was performed on desiccating Xerophyta humilis leaves and a bioinformatic pipeline assembled to identify the potential decoy lncRNAs and miRNAs …
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Annotation of Non-Model Species’ Genomes
… software also allow researchers to examine the noncoding- “ome”, providing a glimpse into gene regulation, developmental pathways, and response to viral sequences and mobile elements. Characterization of the biogenesis pathways of noncoding RNAs has facilitated the development of RNA …
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Regulation of Pumilio RNA Binding Proteins by Long Noncoding RNA NORAD
… transcribed and encodes thousands of long noncoding RNAs (lncRNAs). Defining the mechanism of action of lncRNAs has been a critical challenge and priority for understanding their biological functions. An important example of this is the lncRNA NORAD, which is a highly conserved lncRNA that …
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Description of interactions of Ebola virus with a putative reservoir species using next-generation sequencing
… that permit the selective sequencing of small RNAs, and the characterization of entire viral populations at incredible levels of detail. For this work, I exploited this technology to explore two aspects of the bat/virus nexus; namely the small RNA profile of infection, and the evolution of the …
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