Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"non-viral vector"”.
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Investigation of barriers to non-viral gene delivery and design of novel polymer-based gene delivery systems
… significant challenge facing gene therapy today. Viral vectors remain the dominant approach for addressing the delivery problem; however, concerns regarding the safety of viral vectors have resulted in an increasing interest in non-viral vectors. Non-viral vectors offer the promise of improved …
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Photo-responsive degradable poly (beta-amino ester) toward non-viral gene delivery
… ester) (PBAE) is one of ideal candidates for non-viral gene therapy due to its desired gene delivery efficiency, biocompatibility, and biodegradability. In order to further improve the gene delivery efficiency of PBAE by facilitating the intracellular DNA dissociation, we herein report the …
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Targeting and Reprogramming Tumor-Associated Macrophages with Polymeric Nanoparticle-Mediated mRNA Delivery for Cancer Treatment
… alternative. Since mRNA is unstable, a reliable non-viral vector is required. To enhance drug utilization and meet specific delivery requirements, researchers have increasingly turned to versatile polymeric nanoparticles (PNPs). Compared with other nanocarriers like lipid- or inorganic-based …
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Designing a safe dendronised polymeric nanocarrier for hydrophobic drugs or gene delivery in cancer therapy
… drugs, prolong circulation time, minimise non-specific uptake, and allow for specific tumour-targeting through the EPR effect. Herein, we have proposed the development of a new safe and more specific non-viral vector system based on peptide dendronised polymeric micelles to enhance the …
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Układy samoorganizujące na bazie surfaktantów polimerycznych i formulacji lipidowych, charakterystyka oraz zastosowanie do tworzenia stabilnych kompleksów z kwasami nukleinowymi
… genetic material. A promising candidates for a non-viral carriers are cationic trimeric surfactants, which, due to their multiplied electric charge and the number of alkyl chains, exhibit far better properties than their monomeric counterparts. A potential cytotoxicity of carriers based on …
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ENGINEERING LIPID AND HYBRID NANOVECTORS FOR TARGETED GENE DELIVERY TO MACROPHAGE SUBPOPULATIONS
… the transfection efficiency of the resulting nanovectors (Chapter 1). The experimental part of this thesis is organized presenting first the technological data of the prepared lipopolyplexes (Chapter 2), PLA-PEG/lipid nanoparticles (Chapter 3) and LNP (Chapter 4) and then their in vitro …
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Novel immunotherapy for paediatric cancers
… methods of CAR gene transfer to T cells based on viral vectors are complicated by the time and expense involved in the elaborate protocols required for their implementation.Non-viral transposon technologies may potentially offer a simpler and economical method for generating CART cells. Originally …