Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"non-tuberculous mycobacteria"”.
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Non-tuberculous Mycobacteria in The Gambia: Prevalent Species, Carriage and Disease
Pulmonary tuberculosis-like disease caused by non-tuberculous mycobacteria (NTM) has gained attention, in part, because of its increased recognition especially in the elderly and immunocompetent population. This is an emerging problem of public health significance. With the increasing incidence of …
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Residential Exposure to Non-tuberculous Mycobacteria: Sources and Associations with Pulmonary Disease
The human health impacts of non-tuberculous mycobacteria (NTM) in home environments remain poorly understood. To better understand the association between NTM colonization of POU sources in homes and MAC pulmonary disease (MAC PD), we continued a case-control study of Washington and Oregon …
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Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
Mycobacterium avium belongs to the group Nontuberculous Mycobacterium (NTM), which are acid fast, environmental bacteria belonging to the family Mycobacteriaceae. They are facultative intracellular bacilli causing opportunistic infections in individuals with pre-existing conditions such as …
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Isolation and molecular characterization of Non-Tuberculous Mycobacteria of Public Health significance from Humans and water in Namwala Districts of Zambia
… opportunistic infections due to environmental Non-tuberculous Mycobacteria are increasingly becoming a public health threat due to the Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome pandemic. In Zambia, Non tuberculous Mycobacteria are gaining recognition as pathogens of …
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Isolation and molecular characterization of Non-Tuberculous Mycobacteria of Public Health significance from Humans and water in Namwala Districts of Zambia
… opportunistic infections due to environmental Non-tuberculous Mycobacteria are increasingly becoming a public health threat due to the Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome pandemic. In Zambia, Non tuberculous Mycobacteria are gaining recognition as pathogens of …
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Comprehensive proteomic profiling of clinically relevant strains of Mycobacterium tuberculosis
… complex (MTBC) as well as a clinically relevant non-tuberculous Mycobacteria (NTM) strain when cultured in vitro. We aim to use the experimental data obtained using discovery mass spectrometry to identify candidate proteins to use in the design of multiple reaction monitoring (MRM) MS experiments …
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Growth of Opportunistic Pathogens in Domestic Plumbing: Building Standards, System Operation, and Design
… between controlling Legionella and allowing non-tuberculous Mycobacteria to persist.
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Developing novel therapies for Mycobacterium abscessus
… abscessus (M. abscessus) is a rapid growing non-tuberculous mycobacteria (NTM) that is increasingly recognised as a major pathogen owing to its inherent resistance to a wide range of the currently available antibiotic therapies. In particular, it causes problems in patients with Cystic …
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Screening of the human tumor necrosis factor (TNF) gene and its receptor 1 (TNFR1) gene for DNA alterations and the subsequent investigation of these and an IL12p40 polymorphism for an association with paediatric tuberculosis
… with an unusual susceptibility to progressive non-tuberculous mycobacterial infections. These patients showed defective tumor necrosis factor (TNF) production in response to endotoxin and a failure to upregulate TNF production in response to interferon gamma as well as diminished interferon …
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Design, Synthesis, and Evaluation of Novel Antimycobacterial Agents With Enhanced Pharmacokinetic Profiles
… (XDR-TB) due to a lack of effective treatment. Non-tuberculous mycobacteria (NTM) such as the M. avium and M. abscessus complexes (MAC and MABSC, respectively) are opportunistic pathogens found ubiquitously in the environment. NTM infections have increasing prevalence in patients with structural …
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Towards Optimization of Residual Disinfectant Application for Mutual Control of Opportunistic Pathogens and Antibiotic Resistance in In-Building Plumbing
… Moreover P. aeruginosa, A. baumannii, and non-tuberculous mycobacteria varied substantially in their preference for pipe material and susceptibility to disinfectants. We found that disinfectants tended to increase the relative abundance of OPPPs, ARGs, and mobile genetic elements. …
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The clinical relevance of structural modifications in the cell envelope glycans of Mycobacterium abscessus
… leading causes of pulmonary disease caused by nontuberculous mycobacteria (NTMs) globally. As an opportunistic pathogen, individuals who have dysfunctional immunological and/or mechanical defenses are at the greatest risk of acquiring M. abscessus, but individuals with cystic fibrosis (CF) are …
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Targeting Mycobacterium abscessus Infection in Cystic Fibrosis: A Structure-guided Fragment-based Drug Discovery Approach
… Mycobacterium abscessus, a highly drug-resistant non-tuberculous mycobacterium, which causes life-threatening infections in people with chronic lung conditions like cystic fibrosis. This opportunistic pathogen is refractory to treatment with standard anti-tuberculosis drugs and most currently …