Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"non-synonymous single nucleotide polymorphisms"”.
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Molecular characterization and evolutionary plasticity of protein-protein interfaces
… of methods to predict the likely effect of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on protein stability, function and interactions in order to triage the large volumes of data created from high-throughput genetic screening studies, enabling prioritization of those nsSNPs most …
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Novel Machine Learning Models for Identification, Characterization and Prioritization of Phenotype-Genotype Associations
… model, which simultaneously accounts for non-additive interactions and phenotype heterogeneity while searching for associations. Next, inspired by the hypothesis that some phenotypes can be better explained by additive (small) effects of a large number of variants, I investigate the …
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Mycobacterium tuberculosis strains in New Zealand: phylogeny and structural biology
… the Rangipo strain. Analysis of Rangipo strain non-synonymous single nucleotide polymorphisms (nsSNPs) identified bacterial genetic factors that may contribute to the high transmissibility of this strain. The F420-dependent oxidoreductase Rv2893 harbours a Rangipo-specific G72S mutation encoded …