Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 123 for “"non-steroidal"”.
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Synthesis of Functional Analogs of Non-Steroidal Estrogens
… characteristics of several new, functionalized non-steroidal estrogens is reported. With the aim of developing an estrogen receptor-based radiopharmaceutical, two new iodinated estrogens, 1-(2'-iodo-4'-hydroxyphenyl)-2-(4'-hydroxyphenyl)butane and …
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Pharmacokinetics and pharmacodynamics of non-steroidal anti-inflammatory drugs in birds
… the pharmacokinetics and pharmacodynamics of non-steroidal anti-inflammatory drugs in birds. For decades, the inflammatory process and the properties of the NSAIDs have been extensively investigated in humans and other species. However, current knowledge on inflammation and anti-inflammatory …
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Synthesis of Non-Steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (Protacs)
… destruction sequence and tested as the first non-peptide based PROTAC.
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The Potential of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) in Cancer Cachexia
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The Development of Novel Non -Steroidal Subtype Selective Ligands for the Estrogen Receptor
A series of furan analogs were prepared bearing basic side-chains in the hope to impart anti-estrogenic activity to this class of ligands. The basic side-chain furan analogs were also ER-alpha binding selective ligands (2--47 fold selectivity) and transcriptional assays have shown one particular …
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The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs
… linked glucose residues of varying number. The non-steroidal anti-inflammatory drugs (NSAIDs), a group of agents that share a similar therapeutic effect in the management of inflammatory processes in the body, have been studied as guest molecules for inclusion in cyclodextrins, due to a number …
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The effects of select non-steroidal anti-inflammatory drugs on green and brown hydra
… through waste water treatment plants (WWTPs). Non-steroidal anti-inflammatory drugs (NSAIDs) are important contaminants in water cycles. In this study, several NSAIDs were assessed for their potential toxicity to Hydra. Chronic toxicity was evaluated using three NSAIDs on two different species …
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Clinical pharmacological studies on the interaction between non-steroidal anti-inflammatory drugs and hydrochlorothiazide
Contains fulltext : mmubn000001_028596382.pdf (Publisher’s version ) (Open Access)
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Quantifying the Risk of Beta-Blockers and Non-Steroidal Anti-Inflammatory Drugs in Asthma
Beta-blockers and non-steroidal anti-inflammatory drugs (NSAIDs) are often avoided in asthma over risk of bronchospasm which may vary according to drug selectivity and duration of administration. This thesis attempts to quantify the risk of beta-blocker and NSAID exposure in asthma by synthesising …
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Advanced engineering of Fibrous Non-steroidal anti-inflammatory drug (NSAID) films for buccal application using Electrohydrodynamic Atomisation
The development of therapeutic dosage (e.g. pharmaceutical) systems is an ongoing process which, in recent times has incorporated several emerging disciplines and themes at timely intervals. While the concepts surrounding dosages have developed and evolved, many polymeric excipients remain as the …
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Imaging Prostate Cancer: Design, Synthesis, and in Vivo Testing of Steroidal and Non-Steroidal Androgen Selective PET Radiopharmaceuticals
In addition to our non-steroidal work, we have designed and synthesized some high affinity steroidal compounds to probe the mechanism of androgen delivery to the cellular AR transcription mechanism. Sex hormone binding globulin (SHBG) binds testosterone, the principal circulating androgen, in high …
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LIGHT-DRIVEN STRATEGIES FOR THE GENERATION OF N-OXAZOLIDINONE RADICALS AND THE SYNTHESIS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
… regioselective addition of novel N-oxazolidinone radicals to arenes and heteroarenes, achieved under both photocatalytic and photocatalyst-free conditions in batch and continuous-flow systems; and (B) the application of the photo-Favorskii rearrangement as a key step in the synthesis of …
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STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
… this well-known click chemistry reaction, a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition of naproxen propargyl ester …
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Synthesis and characterisation of new multi-component compounds containing the non-steroidal anti-inflammatory drugs fenbufen and S(+)-ibuprofen
Fenbufen and S-(+)-ibuprofen are non-steroidal anti-inflammatory drugs with poor aqueous solubility. In attempts to improve their solubility and bioavailability, crystal engineering techniques were employed to synthesise salts, co-crystals and cyclodextrin inclusion complexes containing these …
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Effect of a non-steroidal, anti-inflammatory drug (Indocin) on selected parameters of muscular function following concentric and eccentric work
… step test and at five intervals thereafter. A non-significant decrease in PT and TAE at the contraction speed of 60 deg/sec were present in the eccentric limbs, greater reductions evidenced in the placebo group. Non-significant changes occurred in the concentric limbs, Non-significant changes …
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The relative effectiveness of a non-steroidal anti-inflammatory medication (meloxicam) versus manipulation in the treatment of osteoarthritis of the knee
A dissertation submitted in partial compliance with the requirements for the Master's Degree in technology: Chiropractic, Technikon Natal, Durban, South Africa, 2001.
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Control of pain with patient advice sheets: COPPAS. A randomised control trial of advice, acupressure vs non-steroidal anti-inflammatory drugs (NSAIDs)
… of pain after orthodontic treatment compared to non-steroidal anti-inflammatory drugs (NSAIDs). The primary objective was to compare pain experience by assessing the effectiveness of advice to use acupressure or NSAIDs in controlling pain by measuring the degree of pain after bonding of brackets …
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The relative effectiveness of spinal manipulative therapy versus spinal manipulative therapy in conjunction with the administration of non-steroidal anti-inflammatory drugs in patients with facet syndrome
A dissertation presented in partial compliance with the requirements for the Master's Degree in Technology: Chiropractic, Technikon Natal, Durban, South Africa, 1999.
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