Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"non-specificity"”.
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Generics in Use
… I consider explanations according to which non-specificity in generics is a by-product of context-sensitivity or semantic incompleteness, but instead propose that generics semantically express non-specific generalisations by default. In Chapter 3, I present a novel account of the semantics …
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Electrical stimulation of the ventral lateral periaqueductal gray induces antinociception in rats
… morbidity resulting from the toxicity and non-specificity of anesthetic drugs remains high. Among the key behavioral states of general anesthesia is antinociception (reduced sensitivity to pain). Within the nociceptive pathway in the brain and the central nervous system, the periaqueductal …
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Kristevan theory: meanings, contexts, feminist "uses"
… other contemporary theory. I demonstrate that none of these categories or theories can adequately contain Kristevan thought and that her roots in, or resonances with existential philosophy are most important. I particularly stress connections between Kristevan, Sartrean, and Beauvoirian …
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Biophysical investigations of the interaction between substrate binding domain of Hsp40 and the RING finger domain of Retinoblastoma Binding Protein 6
… of the risk of reoccurrence but also due to the non-specificity and side effects of current chemotherapy treatments. Protein-protein interactions have recently come onto the scene as potential targets for novel treatment and management options for the disease. Through a yeast-two hybrid study, …
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Complexation of Organic Guests and Coordination of Metal Ions by Cyclodextrins: Role of Cyclodextrins in Metal-Guest Interactions
… remediation of TNT in soils but it suffers from non-specificity and the need for acidic conditions to prevent loss of iron as iron hydroxides. Cyclodextrins (CDs) have demonstrated the ability to increase the efficiency of Fenton degradation of aromatic pollutant species. The increase in …
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Definiteness and Specificity in Second and Third Language Acquisition of Mandarin Chinese
… the acquisition of (in)definiteness and (non-)specificity by L2 and L3 Mandarin speakers with prior knowledge of Cantonese and/or English. While English has an article system marking the [±definite] features but not the [±specific] features, Mandarin and Cantonese realise these features …
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Η σιελομετρία και ανίχνευση αντισωμάτων στο σίελο, ως διαγνωστικές παράμετροι στο σύνδρομο Sjogren
… resembling 1oSs. This finding indicates the non-specificity of the saliva flow rate tests for the evaluation of xerostomia and strongly suggests that these parameters are not valuable for the clinical evaluation of 1oSs patients. We were able to identify the presence of autoantibodies to …
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Disrupting dynamic f-actin enhances skeletal muscle contraction due to mechanical softening
… cell death, and intracellular organelle damage. None of these downsides actually present themselves with f-actin disruption. Muscle fatigue resistance however does seem to be slightly affected. We performed a detailed characterization of the cytoskeletal modifications that occur during f-actin …
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Positive Polarity and Exhaustivity in Sinhala: A Study of its Implications for Grammar
… quantifiers and intensional operators, that none of the previous accounts has captured. It proposes to analyze the grammar of the two particles based on their positive polarity character associated with exhaustivity (cf. Spector (2014); Nicolae (2017)). It claims that we can account for a …
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A comparative analysis of accuracy and sensitivity in semen presumptive testing: ABAcard P30™, RSID Semen™, and Seratec PSA™
… it was mixed with dirt. There was an issue of non-specificity with all three of the test kits with various absorbent hygiene products. RSID Semen™, Seratec PSA™, and ABAcard P30™ all had several false positive test results with tampons, menstrual pads with blood, and diapers with urine samples. …
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Investigation of Interaction between heat shock protein 70.14 (Hsp 70.14) and RBBP6 RING finger domain
… of these therapies, however, challenges of non-specificity, as well as several side effects, resulting from killing of normal cells by chemotherapeutic agents are still widespread. This has led to urgent and continuous need for alternative therapies aimed at finding alternative drugs, or …
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Discovering the biological and clinical implications of modulating glucocorticoid action using metabolomic profiling of human plasma samples
… excess are difficult to identify because ofthe non-specificity of their clinical and biochemical features which are also poorlycorrelated with levels of circulating steroids. The lack of reliable biomarkers forglucocorticoid action makes it challenging to determine precise therapeutic needsof …
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UNDERSTANDING THE RELATIONSHIP BETWEEN ONCOLYTIC AD5 DELETED E1b55KDA LYTIC INFECTION AND P53 IN MAMMALIAN CELLS
… leading to progressive viral lytic cycle. The non-specificity of replication has limited the use of wild type adenovirus in cancer therapy. This issue was resolved by using an E1b deleted Ad that can only replicate in cells with a deficiency in the p53 protein, a common feature of most cancer …
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Effect of Mesoporous Silica-Loaded Anticancer Drugs on 3D vs 2D Models of Colon Cancer Cells
… suffers from limited efficacy due to its non-specificity and reduced bioavailability at tumour sites, necessitating the development of nanocarriers for enhanced drug delivery. Furthermore, tumour resistance to anticancer drugs warrants evaluation in a suitable 3D model mimicking in vivo …
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The semantics of Russian indefinite pronouns : scope, domain widening, specificity, and proportionality and their interaction
… and koe- indefinites) differ in their degree of specificity. Indefinites with the prefix koe- are epistemically specific (known to the speaker, but unknown to the addressee). They also induce the effect of proportionality (and refer to a part of a given set). As such, they can be analyzed as …
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The preparation and characterisation of highly selective adsorbents for fission product removal from acid solutions
… it has several deficiencies such as flexibility, non-specificity of Tri-Butyl Phosphate (TBP), degradation of the extractant, TBP, and diluent. This project addresses the development of an alternative separation process to either replace and/or complement the PUREX process. Our process is based on …
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Assembly, characterization and evaluation of a 3rd generation nanoparticle based drug carrier for metastatic breast cancer treatment
… limited because their toxic side effects and non-specificity usually lead to low quality lives of the patients. Low aqueous solubility, multi-drug resistance, degradation of drug, limited intra-tumor diffusion and etc. are other limitations of conventional chemotherapies and endocrine …
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Production and purification of fatty acid methyl esters from plant oils of different origin
… hydroxide, has various drawbacks. These include non-specificity leading to saponification, difficulty in isolating the catalyst from the fatty acid methyl esters, immiscibility of the catalyst with the reactants and incomplete transesterification. The aim of the research reported in this thesis …
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Miniaturised analytical systems with chemiluminescence detection for environmental applications
… the purpose of screening the antibody for their specificity towards different isolates of E. coli and their non-specificity towards other bacteria is detailed. Finally, a microfluidic immunoassay was developed. Regeneration of the immobilised antibodies was achieved using 0.5 mol L⁻¹ sodium …