Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"non-selective cation channel"”.
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Lens calcium homeostasis and selenite cataract
… may result from either increased influx (via non-selective cation channel), decreased efflux (via Ca2 +-ATPase and Na+ ICa 2+ exchange) or both. The selenite effects on the different components involved in lens calcium regulation were tested.
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Ion Selectivity and Gating in the NAK Channel
… to proper physiological functioning of ion channels. In this work, a thorough structural characterization of ion binding profiles is presented for the NaK channel, a non selective cation channel from Bacillus cereus, along with an analysis of channel opening and closing mechanisms. An …
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Identification and functional characterisation of a class on non-selective cation channels in Saccharomyces cerevisiae.
… of protein described as voltage insensitive non-selective cation channel(s) (viNSCCs) are considered a good candidate for this Na⁺ flux. This is due in part to characteristics they possess. These characteristics include catalysis of high capacity / low affinity cation flux, being relatively …
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Role of the Transient Receptor Potential Channels in Modulating Prefrontal Cortical Excitability and the Behavioral Responses to Cocaine
… and is mediated by subsequent activation of a non-selective cation channel, which pharmacological data suggested to be a canonical transient receptor potential (TRPC) channel. We used in situ hybridization, immunoblots, and real-time PCR to examine the expression of the TRPC channels and found …
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Angiotensin II signalling in sensory neurons
… subpopulation expressing Tmem45b and binding the non-peptidergic marker isolectin-B4 (IB4), while the other subpopulation lacked both Tmem45b and IB4 binding. The response of IB4-binding sensory neurons to Ang II was mediated by the Type I Ang II receptor (AT1R). Conversely, the response of …
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Understanding Primate Immunity to African Trypanosomes Through the Characterization of Trypanosome Lytic Factor Formation and Function
… cattle, and other livestock. Humans and some non-human primates are protected against most species of trypanosomes due to an innate immunity factor, Trypanosome Lytic Factor (TLF). This modified High Density Lipoprotein (HDL) contains two unique proteins, Haptoglobin Related Protein (HPR), a …
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Cellular Mechanisms Underlying the Action of Melatonin in the Suprachiasmatic Nucleus
… are believed to be indirectly coupled to ion channels. One current that could be modulated by melatonin is the hyperpolarization-activated current(Ih). Ih is a mixed Na+/K+ inward current that plays an important role in the regulation of SCN neurons excitability by limiting the duration of …
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Computational study of the structure and function of membrane transport proteins
… regulated by membrane transport proteins which selectively and efficiently transports materials across the membrane. In the present work I focus on the family of membrane transporters the so called sugar porters in both their mammalian and bacterial forms. In the first work I describe the entire …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise is proposed to mimic a physiological mechanism that influences early DP thymocyte selection and hence the T cell repertoire. During thymopoiesis, the patterning of [Ca2+]i plays a …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise is proposed to mimic a physiological mechanism that influences early DP thymocyte selection and hence the T cell repertoire. During thymopoiesis, the patterning of [Ca2+]i plays a …
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Die Rolle von Kalium- und nichtselektiven Kationenkanälen der Kolonkrypte der Ratte bei Zellschrumpfung
In Untersuchungen mit der Saugelektrodentechnik sind an kultivierten M1-Zellen des kortikalen Sammelrohrs eine nichtselektive Kationenleitfähigkeit bzw. Einzelkanäle beobachtet worden, die bei Erhöhung der extrazellulären Osmolorität aktiviert wurden. An Kolonkryptzellen der Ratte sind …