Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"non-ribosomal peptide synthetases"”.
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Characterisation of microbial Mat communities in meltwater ponds of the McMurdo ice shelf, Antarctica
… producer could not been identified. However non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) genes were identified which could be the genetic basis for novel bioactives. The use of a multi-disciplinary approach synthesis and subsequent results significantly increased …
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Studies of new natural products and their biosynthesis spearheaded by high-resolution mass spectrometry
… immunosuppressant activity are synthesized by non-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). In NRPS and PKS biosynthesis, monomer units are incorporated into a growing natural product chain in an assembly line fashion using a covalent thiotemplate mechanism. Because …
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Analysis of the diverse antibacterial strategies used by <i>Serratia marcescens</i> Db10
… investigated at the molecular level.<br/><br/>Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) are widespread in bacteria and fungi and are responsible for the biosynthesis of many metabolites with medically relevant properties, including antibiotics. The activity of NRPS …
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Efforts Toward Production of Novel Natural Products From Uncultured Soil Microbes
… relevant small molecule antibiotics (glycopeptides), but also to develop, in conjunction with new strategies, improvements on existing metagenomics approaches. My work towards the discovery of novel glycopeptide antibiotics has led to the identification of six novel glycopeptide …
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Detection and further characterisation of the toxins and associated genes of Bacillus cereus
… diarrhoeal toxins (haemolysin BL, enterotoxin T, non-haemolytic enterotoxin, enterotoxin FM and cytotoxin K) have been characterised and subsequently PCR primers have been designed to detect these genes. The PCR methods for three of these toxins (HBL, enterotoxin T and enterotoxin FM) were …