Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"non-proteinogenic amino acids"”.
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Investigations of the Mechanism and Substrate Scope of the Enzymes Involved in Lantibiotic Biosynthesis
The subtilin prepeptide SpaS consists of 56 amino acids that includes five cysteine residues. This peptide is the substrate of the putative lantibiotic dehydratase, SpaB, and cyclase SpaC. The heterologously expressed and purified SpaS peptide was employed in assays with the purified SpaB and SpaC …
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Biosynthetic and Chemical Investigation of Lipid II-Binding Antimicrobials.
… of minimally complex analogs, we determined non-proteinogenic amino acids and the N-acyl fatty acid moiety are essential for bioactivity. For the second project, we investigated a conserved mechanism of action for phylogenetically-related natural products within the lasso peptide subfamily. …
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Investigation of the Lacticin 481 Synthetase and Its Substrate LctA in the Production of the Antibiotic Lacticin 481
… consisting of leader and propeptide regions. The non-proteinogenic amino acids are introduced by the dehydration of serine and threonine residues in the propeptide followed by stereoselective intramolecular Michael-type addition of cysteines onto the unsaturated amino acids. Class I lantibiotics …
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Synthesis of Novel Amino Acids and Peptidomimetics as Tools for Drug Discovery
… doctoral thesis describes the synthesis of novel amino acids and peptidomimetics for use as tools for drug discovery. The first part of this study focuses on the preparation of modified tyrosine analogues using metal-catalysed coupling reactions and the incorporation of these novel amino acid …
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… suitable for small molecule inhibitors are nonexistent. The larger size of peptide inhibitors may, therefore, lead to more specific and tighter-binding candidates for further drug development. This work presents the investigation of the HR1a domain from the RhoA effector, PRK1/PKN1 kinase, …