Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"non-motor symptoms"”.
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Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention
… (PD) is no longer primarily classified as a motor disorder due to the emergence of a number of non-motor symptoms (NMS) of the disease. These NMS are highly prevalent and greatly affect the quality of life of patients with PD. Thus, an animal model that replicates these symptoms is greatly …
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Neuropathological role of alpha-synuclein: major contribution of inflammation in the evolution of both motor and non-motor symptoms of Parkinson’s disease
… of inflammation to the neuropathology of motor symptoms has been ascertained, its role in non-motor symptoms is still under-investigated, particularly in relation to cognitive disturbances. Here, we targeted inflammation in PD by testing the immunomodulatory imide drug (IMiD) Pomalidomide …
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Sintomi non motori e disautonomia cardiovascolare in pazienti sardi affetti da malattia di parkinson con e senza mutazioni del gene LRRK2
… disease (PD) is commonly described as a motor disorder, non-motor symptoms and cardiovascular dysautonomia are important factors of disability and impaired quality of life in PD patients. To date, the definite correlation of cardiovascular symptoms with motor and other non-motor symptoms …
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From effects to affect: the multidimensional impact of dancing with Parkinson’s
… condition characterized by a variety of motor and non-motor symptoms that can lead to increasing disability and complex psychosocial challenges. While medical treatments can help people living with Parkinson’s to manage symptoms, they do not fully address many challenges associated with …
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Targeting Cognitive Impairment in Parkinson’s Disease: Novel Pharmacological and Non- Pharmacological Approaches
… disease (PD) is primarily characterised as a motor disorder, non-motor symptoms represent a significant burden to the PD population. These symptoms include anxiety, depression, fatigue and cognitive impairment (CI), with CI representing the single biggest predictor of quality of life, …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… that was reflected as decreased locomotor activity. In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the LPS-induced dopaminergic neurodegeneration and that the chronic low-grade …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… that was reflected as decreased locomotor activity. In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the LPS-induced dopaminergic neurodegeneration and that the chronic low-grade …
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Dynamic Corticomuscular Coherence during Cyclical Ankle Movements: Effects of Aging and Parkinson’s Disease
… neurodegenerative disease with diverse motor and non- motor symptoms. Although the primary neuropathology and symptoms of PD have been well established, the physiological mechanisms behind specific kinematic abnormalities are not well understood. Many such abnormalities (e.g., gait …
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Targeting neurodegenerative phenotypes and mitochondrial dysfunction in a Drosophila Melanogaster model of Parkinson’s Disease
… substantia nigra part of brain, which leads to motor symptoms such as tremor, rigidity, and bradykinesia, as well as non-motor symptoms includes mood disorders, sleep disturbances, and autonomic dysfunction. Mitochondrial dysfunction, particularly involving Complex I of the electron transport …
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Understanding Socio-Cognitive Impairments in Parkinson's Disease: from Behavioural to Neuroimaging Characterisation
… has consistently demonstrated the presence of non-motor symptoms in patients with PD, including deficits in social cognition. Nevertheless, socio-cognitive dysfunctions in PD remain a relatively underexplored area, and the available tools for assessing these deficits are limited, particularly …
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Evaluating Digital Health Technologies to Advance Parkinson's Disease Care
… disorder characterised by a complex range of motor and non-motor symptoms (NMS). Current PD service provision does not meet the needs of patients, and puts pressure on services with limited capacity. Digital Health Technologies (DHTs), including body-worn sensors and portable devices, may …
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CARDIOVASCULAR AUTONOMIC IMPAIRMENT IN GBA PARKINSONIAN PATIENTS
… has been linked to a higher prevalence of non-motor symptoms compared to idiopathic PD (I-PD), raising the question of whether autonomic dysfunction is more frequent or expressed differently in GBA-PD patients. Objectives: This study aimed to investigate cardiovascular autonomic function in …
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Intervention en téléréadaptation et caractérisation de la dysautonomie cardiovasculaire dans la maladie de Parkinson
… the elderly, is constantly increasing. PD causes non-motor symptoms, such as cardiovascular dysautonomia (CD). Still underdiagnosed in clinics, CD poses risks to patients' health. Physical activity could improve CD and practicing it via telerehabilitation (TR) could reach a larger population. The …
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Health-Promoting Behaviors, Hope, and Health-Related Quality of Life in Persons Impacted by Parkinson’s Disease
… the United States. Parkinson’s disease affects motor and non-motor symptoms and has a variety of complications. Parkinson’s disease is related to genetic and environmental factors. HRQOL decreases in Parkinson’s disease; thus, the effect of hope and health-promoting behaviors on health is …
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The Role of FBXO7 in Mitochondrial Biology and Parkinson's Disease
… central nervous system, manifesting with both motor and non-motor symptoms. Autosomal recessive mutations in the FBXO7 gene have been identified to cause a rapidly progressing early-onset form of PD. Canonically, FBXO7 functions as a substrate-recruiting subunit of the SCF-type E3 ubiquitin …
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ACTING AS THERAPEUTIC SUPPORT IN PARKINSON'S DISEASE. A FIELD EXPERIMENT
… concentrava essenzialmente sulla sintomatologia motoria: l'attuale tendenza invece sottolinea l'importanza dei sintomi non motori e pertanto si orienta verso un tipo di assistenza più complessa, tesa a potenziare le capacità residue di ogni paziente ed a riabilitare, per quanto possibile, le …
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Longitudinal Perspective of Participation in a Double Blind Placebo Surgery Trial
… neurological disorder that causes both motor symptoms and non-motor symptoms in individuals. Overall, PD impacts the physical, emotional and social functioning in the lives of those impacted by the disorder. In 2001, Freed et al. investigated the effects of fetal tissue transplantation …
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Gastrointestinal dysfunction in Parkinson’s disease: Interactions between the gut, immune markers and disease outcome
… disorder, it is also associated with important non-motor symptoms. Gastrointestinal dysfunction in PD (GID-PD) may include weight loss, dysphagia and sialorrhoea. Constipation, the most prominent feature, is often present before the onset of motor symptoms and has a significant impact on quality …
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From Gut to Brain - αSynuclein pathology spreading in a new transgenic mouse model
… αSynuclein (αSyn) and presence of characteristic motor symptoms are cardinal features of PD. The onset of PD motor symptoms is however preceded by non-motor symptoms that can start decades earlier. These may be associated with initiation of αSyn pathology in the peripheral nervous system, more …
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Human Embryonic stem cell-derived A9 dopaminergic neurons as a model and therapy for Parkinson's disease
… in the UK. While PD presents as a combination of motor and non-motor symptoms, the motor dysfunction observed in PD represents one of the most profound and debilitating clinical features. Although there are effective pharmacological and surgical options for those living with PD, all current …
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