Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"non-inferiority"”.
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Bayesian adaptive designs for non-inferiority and dose selection trials.
… to determining if an experimental treatment is non-inferior to an active control treatment within a clinical trial that includes a placebo arm. We incorporate this non-inferiority model in a Bayesian adaptive design that uses joint posterior predictive probabilities of safety and efficacy to …
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Sample size determination for Emax model, equivalence / non-inferiority test and drug combination in fixed dose trials.
… accuracy for the parameter of interest ED₅₀. Non-linear mixed effects model is applied to emphasize the within subjects correlation. To allow for different magnitudes of variability of the population parameters in the Emax model, we proposed three different model structures to account for the …
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A Randomized Non-Inferiority Trial of Technician-Guided and Self-Guided Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy for Cancer Survivors: Making Treatment Scalable
… of ICBT is accessibility; as such, two forms of nontherapist assisted ICBT were investigated in the present study. Cancer survivors with symptoms of anxiety or depression (n = 86) were randomly assigned to receive a transdiagnostic ICBT program (Wellbeing After Cancer) that was either guided by a …
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Comparison of a novel low-cost hyperangulated video intubation stylet with the Bonfils fiberscope: a simulated difficult airway manikin study.
… the HiVIS, as an alternative low-cost device, is non-inferior to the Bonfils. Methods We performed a randomised, cross-over non-inferiority study following institutional and ethics approval (UCT HREC 816/2020). Randomised participants received training (instructional video and practice intubations …
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The role of subgroups and sub-populations in drug development and drug regulation
… data.<br></br><br></br>Chapter Five considers non-inferiority in relation to sub-populations and covariate adjustment for binary outcomes. It is shown that the Per Protocol population is not necessarily conservative and simulation is used to demonstrate the impact on the type I and II errors. …
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Computational Bayesian methods applied to complex problems in bio and astro statistics.
… a particular interval width and establish non-inferiority in the analysis of prevalences using two fallible tests. To this end, we use a third order asymptotic approximation. In the third chapter, we wish to synthesize evidence across multiple domains in measurements taken longitudinally …
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Practice Patterns and Health Outcomes of Adjuvant Oxaliplatin Chemotherapy for Colorectal Cancer
… duration of adjuvant therapy by evaluating the non-inferiority (NI) of 3 versus 6 months of treatment. The 3-year disease-free survival probability was 74.6% in the 3-month group versus 75.5% in the 6-month group (HR 1.07, 95% CI 1.00-1.15; pNI = 0.11). There remain open questions regarding how …
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Bayesian sample-size determination and adaptive design for clinical trials with Poisson outcomes.
… Lastly, we present a new Bayesian meta-analytic non-inferiority method for binomial data that allows researchers a more direct interpretation of their results. Our method uses MCMC methods to approximate the posterior distribution of the new treatment compared to a placebo rather than indirectly …
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The design and delivery of late phase supportive care oncology trials
… and patient support to widen the trial’s non-inferiority margin, impacting the sample size. Recruitment barriers were identified which persisted, despite strategies being developed to address modifiable barriers and confirmation of ongoing clinical support for the trial. Significant …
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Addressing the Challenges of Chronic Disease Management in a Resource-Constrained Health System: The Role of Nurse-Led Shared Care Models for Patients with Rheumatoid Arthritis
… only.Methods:Three studies were conducted: i) a non-inferiority retrospective cohort study with a review of clinical charts; ii) an analysis of the utilization of physician visits; emergency department visits; hospital admissions, and disease-modifying anti-rheumatic drugs using linked chart …
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The influence of body mass index on sensorimotor block and vasopressor requirement during spinal anaesthesia for elective caesarean section
… delivery. In this prospective, observational, non-inferiority study we tested the hypothesis that obesity would not have a clinically important effect on vasopressor requirements or block height. Methods: Two groups of 25 parturients, Group O (BMI >40 kg/m²) and Group N (BMI <32 kg/m²) …
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A randomised control trial comparing occupational therapy interventions that aim to improve developmental outcomes for HIV9positive children (aged 6 months - 5 years) on ART
… revealed similar scores within the predetermined non-inferiority margin and no significant differences at any time point. Conclusion: In conclusion, the low baseline scores confirm the need for occupational therapy intervention in pre-formal school-going HIV-positive children on ART. The PICIHBI …
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Randomised study of EndoRings™-assisted vs. standard colonoscopy for detection of polyps in at risk individuals with Lynch Syndrome
… the EndoRings™ group was 1.4 versus 0.9 in the non-EndoRings™ group (P = 0.60). Conclusion: The present study outcomes observed comparable ADR/PDR in EndoRings™ assisted versus standard colonoscopy with no statistically significant difference. This result may be due to the study's limitations …
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Associations between number of standard doses of tetrahydrocannabinol, cannabis use motives and cannabis-related negative consequences
… cannabis use frequency. I also hypothesized that none of the cannabis use motives would significantly predict cannabis use frequency, cannabis use frequency would not predict cannabis-related negative consequences, and cannabis use frequency would not mediate the relation between cannabis use …
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COPEPTIN AS A SURROGATE MARKER OF ARGININE VASOPRESSIN:CLINICAL DIAGNOSTIC AND PROGNOSTIC APPLICATIONS IN ENDOCRINE AND NON-ENDOCRINE DISEASES
… surrogate marker of AVP in several endocrine and non-endocrine disorders. AVP deficiency (previously known as central diabetes insipidus) is a disorder characterized by hypotonic polyuria with polydipsia. It may ensue after hypothalamus-pituitary surgery and its timely recognition and management …
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Exploring In Vitro and In Vivo Pharmacology of Echinacea Purpurea (L.) Moench
… of clinically diagnosed influenza (flu) to find non-inferiority to the gold-standard therapy Oseltamivir in this indication. Comparable recovery rates were observed for virologically confirmed influenza infections, demonstrating clinical efficacy in the treatment of viral respiratory infections. …
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A study of two models of primary mental health care provisions in Yogyakarta, Indonesia
… pragmatic, two-arm cluster randomised controlled non-inferiority trial. This design enabled an examination of patients derived from whole populations in a ‘real world’ setting. The trial involved two phases: a pilot study in June 2016 with the objectives to refine data collection procedures and to …