Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"non-histone proteins"”.
-
Native chromatin extraction and its structure analysis
… The purified chromatin consists of DNA, histones, chromatin associated RNAs (CARs) and other non-histone proteins. Using the purified chromatin as a source, we developed a biotin-streptavidin mediated enzyme-based immunosorbent assay for simultaneous detection of epigenetic modifications …
-
Investigating The Role of Prmt1 and Arginine Methylation of Hsp70 In Human Pancreatic Cancer
… groups to the arginine residues of its substrate proteins. The best-known substrate for PRMT1 is histone, while more and more non-histone proteins are now found to be methylated by PRMT1. Dysregulation of PRMT1 is reported in several human cancer types. However, its biological roles in human …
-
Biochemical and structural studies of histone and associated proteins from chick and human nuclei
Chromatin is the complex of DNA, histones and non-histone proteins that make up chromosomes and the region of dispersed chromosomes during the interphases and S phase of the cell cycle. It is found inside cell nuclei in eukaryotic cells. There are many important proteins in the nuclei which are …
-
Characterizing The Recognition Motif and Novel Substrates of Carm1
<p>A limited pool of proteins attains vast functional repertoire due to posttranslational modifications (PTMs). Arginine methylation is a common posttranslational modification, which is catalyzed by a family of nine protein arginine methyltransferases or PRMTs. These enzymes deposit one or two …
-
HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… pathogenic antibody production and inflammation. Histone deacetylase (HDAC) 6 is a class IIb histone deacetylase member. HDAC6 has the ability to catalyze the removal of acetyl groups from lysine residues on non-histone proteins. It has been observed that in lupus mouse models, specific HDAC6 …
-
PURIFICATION AND INTERACTION STUDIES OF HISTONE, HMGB, AND PPI PROTEINS, FACILITATED BY THE DIPOLAR NATURE OF HMGBS
High mobility group box (HMGB) proteins are the most abundant non-histone proteins in the nuclei of eukaryotic cells and are highly conserved in animals. They bind dynamically to chromosomal DNA, interact with other proteins including transcription regulators, and have key roles in gene …
-
Molecular mechanisms of the carcinogen chromium(VI)-induced DNA-protein crosslinking in cultured intact human cells
… status" of the cell, 3) To distinguish between proteins directly cross-linked by Cr(III) and those that are cross-linked oxidatively during intracellular Cr(VI) reduction, and 4) To identify major proteins that are complexed to DNA by Cr(III) or via oxidative mechanisms, in MOLT4 cells treated …
-
Defining The Role of Egfr Acetylation In Cellular Processes: Clinical Implications
… so far is that SAHA can inhibit class I and II histone deacetylases (HDACs), which could possibly preserve acetylation of underlying HDAC-targeted proteins including both histone and non-histone proteins. In addition, it has been reported that an HDAC inhibitor, TSA, enhanced EGFR …
-
Isoform-Selective HDAC Inhibition for the Treatment of Lupus Nephritis
… are thought to contribute to disease. Histone deacetylases (HDACs) are a class of enzymes that hydrolyze the lysine bound acetyl group in both histone and non-histone proteins thereby altering protein structure and function. While the use of pan-HDAC inhibitors has proven to be …
-
Non-Histone Nuclear Proteins : Patterns of Synthesis and Phosphorylation During the Cell Cycle, Redistribution at Times of Gene Activation and Properties of Subsets Interacting with HnRNA
… interphase nucleus contains large numbers of nonhistone proteins, the majority of which are associated with chromatin. The amount and number of these proteins varies according to cell type. Actively proliferating cells with high transcriptional activity contain considerably more nonhistone …
-
Structural Basis Of Epigenetic Regulation And Protein Scaffolding In Development And Diseases
… respectively. </p> <p>Primarily identified as a histone lysine methyltransferase, SMYD2 has been shown to be play important roles in muscle development and tumorigenesis. In addition to histone substrate, SMYD2 can also methylate non-histone proteins including p53, retinoblastoma tumor suppressor …
-
Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… the BET (bromodomain and extra terminal) family proteins, represents a class of epigenetic readers that regulate gene transcription by binding to acetylated lysine of histone and non-histone proteins via their bromodomains (BDs). This interaction either changes the availabilities of …