Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"non-genomic"”.
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Rapid Non-genomic Actions of Cortisol in Fish
… (GC) in teleosts signals through either the genomic pathway, by activating the intracellular glucocorticoid receptor (GR) and/or the mineralocorticoid receptor (MR), or through non-genomic pathways. However, the mechanism of action of non-genomic cortisol signalling is far from clear, and …
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Genomic and Non-Genomic Actions of Estrogen Receptor Ligands
… conjugates are large, abiotic, non-degradable polyamidoamine (PAMAM) dendrimer macromolecules that are conjugated to multiple estrogen molecules through chemically robust linkages. Because of their charge and size, these estrogen-dendrimer conjugates (EDCs) remain outside the …
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Chemical Mixtures of Xenoestrogens and Their Metabolites Alter Estradiol-Induced Non-Genomic Signaling
… a plastics monomer, is potently estrogenic via non-genomic signaling; however, bisphenol-S (BPS), a BPA substitute, has unknown endocrine actions. Nonylphenol is a surfactant and a ubiquitous contaminant. Our goals were to use a well-characterized estrogen-responsive cell model, the GH3/B6/F10 …
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The Liver as a Target Organ for the Non-Genomic Actions of Estrogen
… which are not consistent with the classical, genomic responses in target cells. These effects, because of their rapidity and apparent independence from the genome, are termed ""non-genomic"". It is the goal of this thesis to identify tissues which display a non-genomic response to a …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
Nandrolone and other anabolic androgenic steroids (AAS) at elevated concentration can alter the expression and function of neurotransmitter systems and contribute to neuronal cell death. This effect can explain the behavioural changes, drug dependence and neuro degeneration observed in steroid …
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Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
… hormone replacement therapy may have little, none, or detrimental effects on brain health. These studies found differences in health benefits versus risks amongst women who received hormone replacement therapy, depending on age, length of reproductive viability, and the amount of time between …
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The Non-genomic Signaling Pathways Mediated By G-protein Coupled Estrogen Receptor 1 (GPER) In Coronary Arteries
Coronary heart disease (CHD) remains the leading cause of death throughout the world, and postmenopausal women are at particularly high risk for CHD. A promising new avenue of study is the novel G protein-coupled estrogen receptor (GPER) which mediates estrogen action. The major purpose of my …
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Identifying a Glucocorticoid-activated GPCR that Rapidly and Non-Genomically Increases cAMP Levels in Mammalian Cells
… a neutrophilic endotype. One understudied phenomenon of GCs is their ability to induce rapid, non-genomic actions. For example, GCs can acutely modulate calcium concentrations levels, induce smooth muscle relaxation and modulate nitric oxide synthase activity, within minutes and sometimes seconds, …
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Isolation and Characterization of Novel Estrogen Binding Proteins: Physiological Implications
… add new information to our understanding of the non-genomic effects of steroid hormones mediated through those two novel estrogen/testosterone binding proteins.
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Epigenetic Modulation In Braf Mutated Metastatic Colorectal Cancer
… consider gene expression given the relevant non-genomic alterations.</p>
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SYSTEMIC AND TRANSGENERATIONAL REGULATION OF GENE EXPRESSION BY SMALL RNAS IN C. ELEGANS
… that lasts for >200 generations and find that non-genomic signals mediate its expression pattern in every generation. A forward genetic screen to isolate mutants exhibiting re-activation of gene expression (Rage) after many generations of silencing revealed additional defects indicative of …
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Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
… trichostatin-A (TSA). These include the many genomic and non-genomic targets of pan-HDACi, the off-target side effects, and the lack of proven HDAC-dependent cancer pathways predictive of tumor responsiveness. Early observations in our laboratory have shown that <em>in vitro</em> TSA treatment …
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
… have unique effects on the activation of non-genomic signaling in the developing uterus that promotes epigenetic and genetic alterations, which are predictive of developmental reprogramming and correlate with their ability to modulate hormone-dependent tumor development.
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… suggesting steroids act within the CNS in a non-genomic manner, this observation prompted the testing of a panel of steroid molecules at VGLUT. These compounds, known as "neuroactive steroids" have been shown to be synthesized, modified, and/or active within the brain. Research from our lab, …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… suggesting steroids act within the CNS in a non-genomic manner, this observation prompted the testing of a panel of steroid molecules at VGLUT. These compounds, known as "neuroactive steroids" have been shown to be synthesized, modified, and/or active within the brain. Research from our lab, …
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… (DAT). In this dissertation we tested the rapid nongenomic effects of several physiological estrogens [estradiol (E2) estrone (E1), and estriol (E3)] and xenoestrogens (XEs), such as organochlorine pesticides [dieldrin, endosulfan, and o¡¯,p¡¯-dichlorodiphenylethylene (DDE)], plastics …
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The Role of Vitamin D in Skeletal Muscle Function and Regeneration
… binds to its ligand 1α-25[OH]2D3 and initiates genomic and non-genomic rapid signalling responses. At present there is a global prevalence of low serum Vitamin D (25[OH]D) concentrations due to a lack of sun exposure (the primary route for Vitamin D synthesis) as a function of latitude and/or an …
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G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
… is a G-protein-coupled receptor that induces non-genomic signaling in response to some nuclear estrogen receptor ligands. To date, the distribution and functional characterization of GPER within vertebrate organs have been restricted to juvenile and adult animals. However, the role of GPER …
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