Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 76 for “"non-genetic"”.
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NON-GENETIC MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
Acute Myeloid Leukemia (AML) is the most common type of acute hematological malignancy in adults. 40–60% of patients relapse due to the emergence of cellular resistance to anti- leukemic drugs. Drug resistance in leukemic cells has been associated with intratumoral heterogeneity, among which …
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The role of non-genetic variability in Acute Myeloid Leukaemia
… dismal survival. It has a strong reliance on epigenetic and transcriptional factors for disease progression. Accordingly, my lab has previously identified KAT2A, a histone acetyl-transferase, as a requirement for AML maintenance, where chemical inhibition of KAT2A promotes differentiation of AML …
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Etiology of congenital anorectal malformations : genetic and non-genetic risk factors
Contains fulltext : 150170.pdf (Publisher’s version ) (Open Access)
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PERPETUATION OF NON-GENETIC CHANGES AT A TRANSGENE LOCUS IN C. ELEGANS
… to reprogramming mechanisms that erase epigenetic information transmitted from the previous generation and as it develops, the organism goes through experiences that affect gene expression. Despite this, developmental processes give rise to nearly the same organism in the next generation, …
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Genetic and non-genetic determinants of drug response in type 2 diabetes
… in unnecessary treatment failure. In addition to non-genetic factors, geneticfactors are thought to contribute to such variability. </p><p class="MsoNormal" style="text-align:justify;line-height:150%"><b>Aim</b>: This thesisattempts to investigate genetic and non-genetic factors underlying …
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Time to quit? Non-genetic heterogeneity in cell fate propensity after DNA damage
… cell cycles and the transmission of unresolved genetic lesions from one phase to the next. Furthermore, these mechanisms are also believed to underpin the responses of cells, both in normal and cancerous tissues, to those therapies that either directly or indirectly generate DNA damage. In …
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Oncogenic KRAS drives heterogeneity in metabolic and signalling pathways through genetic and non-genetic mechanisms
… research into PDAC and KRAS, the impact of both genetic and non-genetic variability during the earliest steps of carcinogenesis are scantly described. We hypothesise that both forms of heterogeneity might alter the efficiency of PDAC initiation. On the one hand, oncogenic KRAS alleles might …
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Genetic and non-genetic factors involved in modifying the clinical severity of autosomal dominant polycystic kidney disease
… and PKDZ) result in ADPKD, however, additional genetic and non-genetic factors are expected to contribute to the observed phenotypic variance.
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Multiplexed biochemical imaging reveals the extent and complexity of non-genetic heterogeneity in DNA damage-induced caspase dynamics.
Genetically identical cells show a heterogeneous response to a multitude of signals such as growth factors and DNA damage. While this heterogeneity has been shown to be a major determinant of treatment success in several diseases including cancer, little is known about how differences in …
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Characterization of Sympathetic Ganglion Sensitivity to Substance P in a Genetic and a Non-Genetic Rat Model of Hypertension.
<p>Intravenous injection of substance P (SP) stimulates sympathetic ganglia to evoke a greater increase in renal sympathetic nerve activity, heart rate (HR) and blood pressure (BP) in hypertensive than normotensive rats due to upregulation of the NK<sub>1</sub> receptor. These experiments were …
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Developing Novel Methods to Identify RNA-Associated Mechanisms for Inheritance
Animals depend on inheriting non-genetic information early in life to grow and develop naturally. This inherited, non-genetic information was previously thought to be limited to DNA modifications and DNA binding proteins. But recent studies have expanded our understanding of inheritance to include …
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Intergenerational and Transgenerational Effects of Endocrine Insults
Environmental perturbation can lead to non-genetic, non-Mendelian transmission of acquired traits to descendants. Such inheritance may be intergenerational or transgenerational, the latter describing effects that persist in the absence of any exposure (either directly or of parental germ cells) to …
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Cardiomyocyte Cell Cycle, Renewal and Isolation
… mature cardiomyocytes (paper IV). We establish a non-genetic FACS based technique utilizing the surface marker VCAM-1, facilitating the enrichment of embryonic cardiomyocytes (paper III). Additional surface markers are assayed for their potential to isolate cardiomyocytes from other time-points in …
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Application of molecular markers to early generation testing in maize breeding
… (Zea mays L.) inbreds. Even though the expected genetic correlations between testcross performance in different generations is high, non-genetic effects reduce the effectiveness of early-generation testing. This experiment was conducted to determine the usefulness of molecular marker information …
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The Discordant Development of Sexual Orientation in Identical Twins
The present thesis investigated how genetically identical twins with discordant sexual orientations differed in correlates of their sexual orientation in order to understand to what degree non-genetic factors affect the formation of sexual orientation. Because identical twins share 100% of their …
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Oncogene-induced remodelling of cellular networks
… stressors. During carcinogenesis, cells accrue genetic alterations that rewire signalling pathways, eventually leading to the partial loss of homeostatic control and cancer- related phenotypes. Cancer is a very heterogeneous disease with genetic alterations that exhibit vast variability within a …
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Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors
… this is reported to be attributed to by various genetic and nongenetic factors. Non-genetics factors implicated in the warfarin dose variability include age, gender, body weight, comorbidities and concomitant drugs. Genetic factors affecting warfarin dose variability include variation in genes …
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Isolation of low ethanol producing yeast strains using adaptive evolution
This thesis describes the application of a non-genetic engineering approach, adaptive evolution, to generate variants of Saccharomyces cerevisiae that produce reduced levels of ethanol relative to the strains they were derived from. Sub-lethal concentrations of sulfite, which sequesters …
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An implantable piezoelectric ultrasound stimulator (ImPULS) for selective deep brain activation
… focal point pressure of 100 kPa and can non-genetically modulate the activity of neurons. We demonstrated that ImPULS can i) excite neurons in a mouse hippocampal slice ex vivo, ii) activate cells in the hippocampus of an anesthetized mouse to induce expression of activity-dependent gene …
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Molecular Phylogenetic Analysis of Novel Spiroplasma Isolates
… the closely related spiroplasma isolates. Phylogenetic analyses and non-genetic character mapping indicated that all study isolates belonged to the Apis clade; arginine hydrolysis was a strong indicator of evolutionary relatedness; surface serology and phylogenetic placement were congruent; and …
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