Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"non-disjunction"”.
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Cellular/Molecular Analysis of Interspecies Sterile Male Hybrids In Drosophila
… The genetic and cellular basis of this phenomenon is unknown. My objective was to describe the stage at which spermatogenesis fails in hybrids produced from three interspecies crosses in Drosophila. I found that chromosomes do not separate after meiosis I, leading to non-disjunction, and the …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… anaphase ultra-fine bridges indicating chromatid non-disjunction at intrinsically labile common fragile site loci. Furthermore, we detected an increase in RPA and γH2AX foci in S/G2 cells indicative of replication stress-induced DNA damage potentially indicating chronic replication fork stalling …
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Equine Spermatogenesis: Meiotic Chromosome Behavior and Recombination
… frequency and positioning can cause non-disjunction and generation of aneuploidy. The frequency and distribution of chiasmata were estimated at MI chromosomes from fourteen fertile stallions. The average frequency of autosomal chiasmata was 49.45 ± 2.07, corresponding to a genetic …
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The physiological role of the two isoforms of DNA topoisomerase II in human cells
… of the IIalpha-form. Chromosome condensation and disjunction was performed with the aid of cytosolic topoisomerase IIalpha which bound to the mitotic chromatin with low affinity. Consequently an increased rate of nondisjunction is observed in these cells. It is concluded that high affinity …