Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"non-cell-autonomous"”.
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ENDOCYTIC CONTROL OF CELL-AUTONOMOUS AND NON-CELL-AUTONOMOUS FUNCTIONS OF P53
… recognized for its role in determining cell fate decisions through inhibition of NOTCH signaling, a process achieved via endocytic trafficking. Subsequently, NUMB has emerged as a significant tumor suppressor, particularly in the context of breast cancer, where it stabilizes the critical …
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P53 Drives A Transcriptional Program That Elicits A Non-Cell-Autonomous Response and Alters Cell State In Vivo
<p>Cell stress and DNA damage activate the tumor suppressor p53, triggering transcriptional activation of a myriad of target genes. The molecular, morphological, and physiological consequences of this activation remain poorly understood <em>in vivo</em>. We activated a p53 transcriptional program …
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MOTONEURON MAINTENANCE DEFECTS AND NON-CELL AUTONOMOUS CONTRIBUTIONS BY SCHWANN CELLS IN ZEBRAFISH MUTANT AND MORPHANT MODELS FOR SPINAL MUSCULAR ATROPHY
… Studies in SMA animal models suggested a non-cell autonomous contribution of Schwann cell defects to MN degeneration. Supporting this, I found that restoration of Smn in Schwann cell precursors (SCPs) of smn morphants partially ameliorates MN defects. Transcriptome analysis of Smn …
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Developmental trajectory of functional neocortical networks in an in vitro mouse model of Rett syndrome
… is poorly understood. Compared to molecular or cellular studies, microscale network analysis may reveal how genetic mutations influence neuronal circuitry relevant to behaviour. Investigating how microscale functional networks are disrupted in RTT in humans remains challenging. In contrast, …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
… short-range signaling between neighboring cells. Notch signaling has been implicated in various cellular and developmental processes essential in the life of metazoans. Specifically, Notch signaling plays a critical role in mammalian skin. Removal of Notch alleles in skin keratinocytes has …
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Targeting Ion Channels to Distal Dendrites
… primary compartments are further divided in some cell types, allowing the dendrite to expand its information processing power. For example, in CA1 pyramidal neurons of the hippocampus, a brain region crucial for memory formation, the apical dendrite is divided into a proximal and a distal …
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Interplay between Piezo1-mediated mechanosensing and the chemical guidance cue Semaphorin3A during development of the embryonic nervous system
… to their destination. Here, retinal ganglion cells (RGCs) send their axons out of the retina, to cross with axons of the opposite eye in the optic chiasm and continue their journey through the diencephalon as an optic tract, before reaching their target, the optic tectum. During formation of …
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CONTROL OF CELL DIVISION AND DIFFERENTIATION IN THE ARABIDOPSIS ROOT - STUDIES ON THE AUXIN RESISTAN 3 (AXR3) GENE
Tight and balanced control of cell division and cell differentiation is crucial for plant development. In Arabidopsis, auxin signaling mediated by its repressors AUX/IAA proteins, plays a key role in mediating root development and growth. However, it is still not well understood how AUX/IAA …
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Pericyte deficiencies in a foxf2 loss of function mutant
… decreased pericyte density but a combination of cell-autonomous and non-cell-autonomous effects. A downstream target of foxf2a, loxl2b, is downregulated in foxf2 mutants. While loxl2b mRNA is sufficient to boost brain pericyte numbers, mutants for this gene do not show an obvious phenotype, …
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The analysis of a mouse model of Lysosomal Storage Disorder uncovers a role for astrocyte dysfunction in neurodegeneration
Astrocytes are the most abundant cellular population in the brain and their role in neurodegenerative processes is becoming increasingly appreciated. In my PhD project, I investigated the contribution of astrocytes to neurodegeneration in Multiple Sulfatase Deficiency (MS D), a severe Lysosomal …
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The retinoblastoma gene family in tumor suppression and development
… embryos and adults made with marked Rb-/- cells. We demonstrated that although brains of chimeric embryos exhibited extensive ectopic S-phase entry, unlike in germline Rb-/- littermates, in these chimeras the majority of Rb-deficient cells survived and differentiated into neuronal fates. …
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Unraveling the molecular mechanism underlying ALS-linked astrocyte toxicity for motor neurons
… transgenic mutant SOD1 mice indicate that non-neuronal cells, such as astrocytes, play an important role in motor neuron degeneration. Consistent with this non-cell autonomous scenario are the demonstrations that wild-type primary and embryonic stem cell-derived motor neurons selectively …
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Cell-specific roles for CASK in the pathology of Optic Nerve Hypoplasia
… we know little about the genetic, molecular, or cellular mechanisms underlying ONH. A previous study described ONH in a cohort of patients with mutations in CASK, an X-linked gene with established roles in neural development and synaptic function. I have demonstrated that heterozygous deletion of …
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Understanding the Conserved and Species-Specific Functions of FOXP2, a Gene Implicated in Speech and Language Development
… it may also inspire research of the conserved, non-cell-autonomous role of FoxP2 in the maturation of thalamocortical circuitry. Additionally, I performed ChIP-seq and RNA-seq in human neural progenitor cells and found evidence that FOXP2 may actively modify the chromatin landscape. This lead me …
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Eph-Ephrin Signaling and the Role of EFN-4 in Caenorhabditis Elegans Nervous Systems Development
… indicate that <em>efn-4</em> is required non-cell autonomously in the hypodermis to promote axon extension. Also, non-cell autonomous expression in the body wall muscle is sufficient to rescue anosmin-dependent axon branching, suggesting that primary axon outgrowth is genetically distinct …
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The developmental transcriptional landscape and organizing function of the sieve element in the root meristem
… in sieve elements, specialized tube-like cells in the phloem. While several regulators of sieve element differentiation have been described, many remain unknown. Furthermore, the temporal cascade of differentiation regulation remains unclear due to limited resolution in published data. In …
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Investigation into the destructive and adaptive responses of neural cells to stress
… as increase their capacity to buffer their intracellular redox balance. Finally, I have studied transcriptional programs in astrocytes triggered by neurons and neuronal activity to better understand adaptive signaling between different cell types in the neuro-glial unit. I developed a novel …
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The Hippo Signaling Pathway in Organ Size Control and Regeneraton
The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. Our lab has previously demonstrated that Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) …
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Functional Analysis of SOX11 and NF1 in Sensory Neuron Development and Plasticity
… of sensory neurons is controlled by both cell-extrinsic and cell-intrinsic factors. The transcription factor Sox11 is abundantly expressed in embryonic sensory neurons. In the first part of this thesis, by using a Sox11-/- mouse model, I show that the loss of Sox11 results in increased …
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A toxicological analysis of the cyanotoxin β-methylamino-L-alanine at multiple neural levels and identification of novel modes of activity
… here indicate that BMAA induces increased intracellular Ca2+ influx, DNA damage, mitochondrial activity, lactate dehydrogenase (LDH) release and generation of ROS in human neurons. The amelioration of LDH release in the presence of the N methyl-D-aspartate (NMDA) receptor antagonist MK801 …
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