Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"non-canonical inflammasome"”.
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Novel Proteases That Regulate Interleukin-1 Alpha Activity During Inflammation And Senescence
… cleaves pro-IL-1a during the activation of the non-canonical inflammasome by cytosolic LPS, which mimics intracellular bacterial infection. We also demonstrate that caspase-5-cleaved IL-1a mediates the senescence-associated secretory phenotype (SASP), which drives the deleterious effects of …
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The Activation of the Inflammasome during Rickettsial Infection
… In this dissertation, I have investigated the canonical and non-canonical inflammasome activation by rickettsiae in mouse macrophages. The central hypothesis is that activation and priming by lipopolysaccharide (LPS) of caspase-11 and ASC-dependent inflammasomes in macrophages is essential for …
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Inflammasomes in the Intestinal Epithelium
Inflammasomes are multiprotein signalling complexes that detect a diverse range of pathological stimuli to activate inflammatory caspases, resulting in cell death and the release of IL-18 and IL-1. Inflammasomes are important in a wide range of diseases, in particular with auto-inflammatory …
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Caspase isoforms in inflammasome activation
Inflammasomes are macromolecular signalling platforms composed of a receptor (for example NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the …
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Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease
… the pyrin domain-containing NLRP subfamily. The canonical NLRPs are inflammasome-forming proteins responsible for the activation of caspase-1 and the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. In contrast, the non-canonical inflammasome-independent NLRPs regulate …
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Fatty Acid Regulation of NLRP3 Inflammasome Activity
… inflammation that is driven in part by the NLRP3 inflammasome. This macromolecular complex responds to diverse danger signals by inducing secretion of inflammatory IL-1 family cytokines and promoting a type of cell death called pyroptosis. Saturated fatty acids (SFAs) are known to activate the …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… such as Nckap1, Fip1l1, Srsf10, Safb. However, none of these additional candidates were validated because their deficiency did not provide significant resistance to the cell death phenotype. Overall, these results suggest that, in addition to the Caspase-4-Gasdermin-D axis, the role of …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… of enteric neuronal cell death, involving the non-canonical inflammasome components NLRP6 and caspase 11. In further characterizing enteric neuronal populations, we identified a subset of intestinal CART+ neurons that were enriched in the distal intestine and modulated by the microbiota. …