Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"non-canonical autophagy"”.
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A study on non-canonical autophagy signalling
… of all resources upon nutrient depletion. Autophagy is an essential catabolic process induced to provide cellular energy sources in response to nutrient limitation through the engulfment of intracellular content in double-membrane vesicles known as autophagosomes, which fuse with lysosomes …
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ATG8 Regulation and Function in Non-Canonical Autophagy
Canonical autophagy is a fundamental, catabolic process that targets cytoplasmic components for lysosomal degradation. In a defining step of this pathway, ATG8 subfamily proteins (LC3s and GABARAPs) are recruited to double membrane autophagosomes where they facilitate substrate capture, membrane …
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Novel mechanisms of Atg16L1 recruitment in non-canonical autophagy
Autophagy is a well-studied catabolic process through which cytoplasmic components are targeted for lysosomal degradation by autophagosomes. A key step in this process is the recruitment, processing and lipidation of LC3 to autophagosomes. Recently it has become increasingly apparent that, through …
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The Role Of ROS-mediated ERK and JNK Activation In The Induction Of Autophagy And Apoptosis In Tumour Cells By A Novel Small Molecule Compound
… caspase-independent cell death pathway, termed autophagy, which is activated in response to growth factor deprivation or upon exposure to genotoxic compounds. It should be noted that autophagy has been described as a cell survival mechanism as well as a death execution pathway. Using a novel …
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Inheritance, innovation, and adaptation of immune systems: Regulation of the Innate Immunity Sensor Stimulator of Interferon Genes (STING)
… a proton channel, which plays a role in inducing non-canonical autophagy and inflammasome activation. Additionally, we demonstrated that mammalian cells employ DNAJC13 to prevent the accumulation of aggregated STING following its activation. This mechanism serves to avoid excessive activation of …
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Evaluation of the role of autophagy in ovarian cancer chemoresistance
… cancer cells may gain resistance to treatment. Autophagy is a highly conserved catabolic process, that enables cells to cope with stressful conditions. We have demonstrated, using flow cytometry and western blot analysis of LC3, that three ovarian cancer cell lines, that induced only limited …