Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 296 for “"non-canonical"”.
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Non-canonical sensing mechanisms in bacteria
… vary among bacterial species, they all share a canonical mechanism to sense and respond to these simple molecules. Little is known about chemotaxis to other molecules and the governing sensing mechanisms. In this work, we studied chemotaxis to unconventional molecules in the B. subtilis …
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A study on non-canonical autophagy signalling
… downstream regulators such as ULK1, which in the canonical pathway is known to activate the VPS34 complex, resulting in the formation of PI(3)P-containing autophagosomes. A failure to induce functional autophagy has been implicated in a range of neurodegenerative diseases, in which the aggregation …
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Probing Non-Canonical DNA Structures With Anticancer Drugs
T:G mismatched base pair is associated with many genetic mutations. Understanding its biological consequences can be aided by studying the structural perturbation of DNA caused by T:G base pair and by specific probing of the mismatch using small molecular ligands. We have shown that AR-1-144, a …
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ATG8 Regulation and Function in Non-Canonical Autophagy
Canonical autophagy is a fundamental, catabolic process that targets cytoplasmic components for lysosomal degradation. In a defining step of this pathway, ATG8 subfamily proteins (LC3s and GABARAPs) are recruited to double membrane autophagosomes where they facilitate substrate capture, membrane …
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Human non-canonical translation initiation factors EIF4E2 and EIF4E3
… in global translation and is considered canonical. EIF4E2 and EIF4E3 are non-canonical translation initiation factors. This thesis summarizes current knowledge on EIF4E2 and EIF4E3. EIF4E2 and EIF4E3 structures differ from EIF4E1, with some key amino acid residues being replaced. This …
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Processing of non-canonical word orders in an L2
This thesis investigates the processing of non-canonical word orders and whether non-canonical orders involving object topicalizations, midfield scrambling and particle verbs are treated the same by native (L1) and non-native (L2) speakers. The two languages investigated are Norwegian and German. …
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Novel mechanisms of Atg16L1 recruitment in non-canonical autophagy
… LC3 can also become lipidated to distinct non-autophagosomal membranes of the endolysosomal system. This process is termed non-canonical autophagy and occurs independently of conventional autophagy initiation signals. Non-canonical autophagy usually occurs after macro endocytic engulfment …
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A Neuroprotective Role for Mir-1017, a Non-Canonical Mirna
<p>miRNAs are post-transcriptional regulators of gene expression, with numerous being involved in neurobiology. Within the human genome a quarter of the identified miRNA loci derive from a class of miRNAs termed tailed mirtrons. Despite the identification of this large population of miRNA, no …
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Non-Canonical Odor Coding Ensures Robust Mosquito Attraction to Humans
<p>Aedes aegypti mosquitoes spread deadly diseases, including dengue, Zika, yellow fever, and chikungunya. Only female mosquitoes bite, and they do so because they require a blood-meal for reproduction. Aedes aegypti prefer to bite human hosts, which contributes to their effectiveness as a deadly …
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Non-Canonical Axonal Insulin Receptor Signaling Drives Aversive Olfactory Learning
… and availably of food. The volatile chemical butanone is a common product of bacterial metabolism, and therefore a bacterial odor that is attractive to worms. However, exposing C. elegans to butanone vapor while depriving them of food can suppress this attraction. C. elegans senses butanone with …
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Canonical and non-canonical regulation of AMP-activated protein kinase
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy stress that, once activated, promotes ATP-producing process while it switches off ATP-consuming pathways, in order to restore the cellular energetic balance under conditions of stress. Activation of AMPK is dependent on the …
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Investigating non-canonical vertebral development in the zebrafish model system
… however, how applicable this amniote-based ‘canonical’ mechanism is across the vertebrates. In fact, the vast majority and diversity of vertebrates are not amniotes, but are members of ‘fish’ groups where there has been relatively little investigation into vertebral development. Indeed, there …
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Sequence Effects and Ligand Selectivity in Targeting Non-Canonical DNA Structures
G-Quadruplex (G4) DNA is a secondary DNA structure that can occur in G-rich DNA sequences. These structures, which are compact and diverse, have been implicated in a wide range of processes including telomere maintenance, transcriptional control, and DNA replication and repair. In order to target …
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Non-Canonical Roles of Cytosolic Phosphoenolpyruvate Carboxykinase in Small Intestine Metabolism
… profiles were dramatically different. Nearly all non-essential amino acid concentrations were increased, and nearly all essential amino acid concentrations were decreased. Intestinal TCA cycle and related pathway fluxes were decreased by approximately half, and enterocyte oxygen consumption was …
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A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
… that have been mostly studied in leukocytes. Canonical NLRP3 or AIM2 inflammasomes regulate cytokine maturation and pyroptosis via ASC and caspase-1 activation. Emerging studies demonstrate that NLRP3 or AIM2 is expressed in non-haematopoietic cells such as tubular epithelial cells (TEC) in …
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Characterisation of the non-canonical zinc finger protein ZFP263 in mouse
… binding sites are not associated with the canonical KZFP co-factor but mostly co-localize with active histone marks. My findings lead me to hypothesise that ZFP263 has evolved to target active epigenetic states to unique regions that are positive regulators of transcription, in contrast to …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… iron through an allosteric mechanism and that a non-canonical association of (i) transferrin, (ii) the iron-mimic ligand motif, and (iii) transferrin receptor mediates binding and transport of particles across the BBB. We also show that in orthotopic human glioma xenografts, a combination of …
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