Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"non-apoptotic"”.
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
… development, homeostasis, and disease. While apoptotic cell death has been extensively studied, many dying cells in development do not exhibit apoptotic morphology, and mice lacking core apoptotic regulators have mostly normal rates of developmental programmed cell death. However, little is …
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Genetic determinants of cell sensitization to parvovirus H-1-induced activation of non-apoptotic death pathways
… and counteracting the induction of apoptotic cell death. An alternative therapeutic approach relies on the use of autonomous parvoviruses. These small, non enveloped, single-stranded DNA viruses are endowed with the capacity to kill malignant cells while being non-cytopathic towards …
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A New Type of Programmed Cell Death in C. Elegans
… controlled by conserved gene pathways. Although non-apoptotic, caspase-independent programmed cell death pathways have been postulated, there is little evidence to convincingly prove their existence, and few insights regarding their molecular basis or possible in vivo functions. To investigate …
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Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
… to apoptosis need novel strategies for inducing non-apoptotic cell death. Paraptosis is a kind of non-apoptotic cell death and characterized by extensive vacuolization due to dilation of mitochondria and the endoplasmic reticulum (ER). However, the regulatory mechanisms that control paraptotic …
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Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells
… induce an aborted autophagic program followed by non-apoptotic cell death in STS-26T cells. This distinct phenotype observed with FTI-1/lovastatin is the consequence of their action on the lysosomal trafficking of proteins. The compounds impaired procathepsin trafficking via the endocytic pathway …
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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
… Direct evidence that caspase-independent non-apoptotic cell death pathways operate during animal development is provided by studies of the C. elegans linker cell. Genetic studies of linker cell death have led to the identification of genes that promote this process, including pqn-41, which …
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Examining the Impact of PUFAs and the Role of Autophagy in Iron-Induced Ferroptotic Cell Death
Ferroptosis, an iron-dependent non-apoptotic cell death involves lipid peroxidation and associates with cardiometabolic disease and cancer. I established a model of iron overload in L6 cells and measured cell viability, toxicity and lipid peroxidation. Importantly, in PUFA pre-treated cells, the …
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Ice Recrystallization Inhibition as a Mechanism for Reducing Cryopreservation Injury in a Hematopoietic Stem Cell Model
… of umbilical cord blood and recovery of viable non-apoptotic cells and hematopoietic progenitor function. Furthermore, increased numbers of apoptotic cells in hematopoeitic stem cell grafts were associated with reduced hematopoietic function and delayed hematopoietic recovery in patients …
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… is constitutively associated with the ER under non-apoptotic conditions. This is likely mediated by a novel lipid binding activity of the first BRCT (BRCA1 C-Terminus) domain of BRCA1. Lastly, phosphatidic acid, which is was identified in a lipid binding screen, is produced at the ER during …
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E2F1 and Tumor Suppression: The Role of P21, Mirnas, and The Dna Damage Response
… in response to ras activation through a non-apoptotic mechanism requiring ARF and p53, but not p21. However, p21-loss inhibited two-stage chemical carcinogenesis in FVB mice. In response to E2F1 overexpression, we found that 22 miRNAs are differentially regulated in mouse epidermis, …
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Characterizing the Cellular Response to Astrovirus Infection in the Central Nervous System
… molecular mechanisms by which AstV, specifically non-classical VA1 and classical HAstV1 genotypes, induce CNS pathology in human neurons and astrocytes. Utilizing primary human neurons and astrocytes from various brain regions, this research investigates the cytotoxic effects, apoptotic pathways, …
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ELUCIDATING THE MOLECULAR DETERMINANTS OF P53-MEDIATED PLEIOTROPIC EFFECTS IN SMALL CELL LUNG CANCER
… tumors such that p53 reactivation induces a canonical senescence response in a subset of tumors, while, in others, p53 induces a non-apoptotic form of cell death that culminates in necrosis. We pinpointed the cyclophilin family of peptidyl prolyl cis-trans isomerases as critical determinants of …
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Study of biological phenomena implicated in neuromuscular ageing
… and (4) denervation is achieved by activating non apoptotic caspase 3. Regardless of whether it was achieved with muscle (α-Bungarotoxin), nerve (α-Latrotoxin) targeted neurotoxins or an endogenous pruning cue (SPARC), synaptic inactivity increased mitochondrial and cytosolic ROS in vivo. In …
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The effects of thymic hormones on the proliferation of human myelogenous leukemia cells
… proliferation indicating that TF5 acts through a non-apoptotic mechanism. The results of morphological analyses and the TUNEL assay demonstrate that TF5 does not induce apoptosis in HL-60 cells, suggesting that the mechanism of inhibition involves cytostasis. Further purification of TF5 by gel …
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Investigation of the effect of microwave irradiation (2.45 GHz) on biological systems at constant bulk temperature
… temperature. Also, microwave treatment while non-apoptotic, significantly increased the rate of reduction of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) by PC-3 cells. Further studies revealed that MW irradiation (10 W, SAR: 700 mW/ml) could significantly increase the …
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An unbiased proteomic approach to identifying cell surface markers in neutrophils
… have been described, the critically important ‘apoptotic-cell-associated molecular patterns’ have yet to be identified. Methods: Human whole blood samples were obtained from healthy volunteers. Neutrophils were isolated and subjected to a temperature shift to facilitate a wave of synchronised …
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Of Apoptosomes and Oncogenes: Repurposing a Death Machine & Deconstructing the Action of P53 Mutations
… caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. I show here that Tango7 genetically interacts with the apoptotic machinery but instead of …
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The role of apoptosis in <i>in vitro</i> and <i>in vivo</i> models of amyotrophic lateral sclerosis
… I found that: I) BDNF deprivation produced apoptotic cell death, II) AMPA and kainate induced apoptotic or non apoptotic cell death depending on the experimental conditions utilized, III) EPO selectively protected motor neurons committed to dye apoptically.<br></br><br></br> In wobbler mice …
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Components Required for the Death and Degradation of the Linker Cell in C. Elegans
… engulfing cells. This process does not rely on canonical apoptotic factors, so I carried out a forward genetic screen to identify genes involved in corpse degradation. I discovered a key protein network involved in linker cell corpse engulfment and degradation and revealed that two small GTPases, …
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Directed Migration Achieved in Mammalian Cells via Ca2+ Signal Rewiring in Synthetic Protein Chimeras
… Ca2+ signal that in turn activates CaRQ-mediated non-apoptotic blebs allowing migration towards the TNFα source. Next, the addition of VSVG, upon low pH induction, causes membrane fusion of the engineered and TNFα source cells. Finally, post-ganciclovir treatment, cells undergo death via the …
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