Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"non-Hodgkin lymphoma"”.
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Engineering delivery systems for the treatment of Non-Hodgkin lymphoma
… cancers, including various leukemias and lymphomas, are among the top 10 cancers diagnosed in people. The leukemia and lymphoma society estimates that there are nearly 1.7 million people in the United States living with or in remission from hematological cancers. The frontline therapeutics …
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
The commonest childhood Non-Hodgkin Lymphomas (NHLs) form three major categories: the aggressive mature B-cell NHLs including Burkitt lymphoma (BL), Anaplastic Large Cell Lymphomas (ALCL), and lymphoblastic lymphomas. Most childhood NHL is high-grade and generally responds well to high-intensity …
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Investigating heterogeneity and mechanisms of resistance in paediatric B-cell non-Hodgkin lymphoma
Paediatric mature B-cell non-Hodgkin lymphoma (B-NHL) is a highly aggressive disease with one of the fastest growth rates of any human malignancy. The subtypes are Burkitt and Burkitt-like lymphoma/leukaemia, diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma; with Burkitt …
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Clinical-pathological characterisation of children with B-cell non-Hodgkin lymphoma over a ten year period at a tertiary centre in Cape Town
Background: We characterized B-cell non-Hodgkin lymphoma (NHL) cases over ten years at a tertiary children's hospital to contribute to the body of knowledge on pediatric lymphoma in developing countries with a high human immunodeficiency virus (HIV) burden. Methods: A retrospective cohort study …
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Review of Diffuse large B cell lymphoma, pharmacological aspects of treatment and comparison of outcome between Pre-,Post Rituximab era
Diffuse large B Cell lymphoma (DLBCL) is a type aggressive non-Hodgkin Lymphoma (NHL). About 30% of patients who diagnosed NHL is DLBCL in both male and female. It is divided into 3 major types which distinct by immunological characteristics. It shall shows variable spectrum of prognosis and …
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Elucidating Targetable Genetic Vulnerabilities in Relapsed/Refractory Diffuse Large B-cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most prevalent form of non-Hodgkin lymphoma is marked by significant heterogeneity in its morphology, genetic irregularities, and clinical behavior. Current prognostic tools, including the International Prognostic Index and cell-of-origin transcriptional …
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Spectrum and Incidence of Primary and Therapy-Related Hematologic Malignancies In Individuals With Brca1 and Brca2 Pathogenic Variants
… malignancies were identified (2.97%): non-Hodgkin lymphoma in 9/706 individuals (1.27%), chronic myeloid leukemia and multiple myeloma each in 2/706 individuals (0.28%), respectively, and acute myeloid leukemia, unspecified leukemia, and Hodgkin lymphoma each in 1/706 individuals …
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Efficacy of Dual Cd19-Cd79B Car In B-Cell Malignancies
… and robust cytotoxic activity against B cell lymphoma and leukemia cell lines expressing either CD19 or CD79b or both. The expression of two distinct CAR molecules in the same cell did not adversely affect T-cell differentiation during the CAR T generation as the phenotype and expression of …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… Analysis of the lymph node from a patient with non-Hodgkin lymphoma showed that the structural integrity of the lymph node was totally lost. The important role of CD40 signalling for B cell activation and survival was investigated by activation of CVID naive B cells with human CD40L and showed …
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Optimization of BRAF V600 Assay as A 2-Step Real-time PCR Protocol
… this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even prostate cancer. Currently, the established qPCR protocol for the QClamp® BRAF Mutation Detection Assay …
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Investigating the genome of Anaplastic Lymphoma Kinase-positive Anaplastic Large Cell Lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is a T cell Non-Hodgkin Lymphoma, mainly presenting in paediatric and young adult patients. The majority of cases express a chimeric fusion protein resulting in hyperactivation of Anaplastic Lymphoma Kinase (ALK) as the consequence of a chromosomal …
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An investigation of Epstein-Barr Virus (EBV) latency type and MYC gene aberrations in plasmablastic lymphoma diagnosed at Groote Schuur Hospital, Cape Town, South Africa
Introduction: Plasmablastic lymphoma (PBL) is a rare, aggressive, AIDS-associated non-Hodgkin lymphoma. The pathogenesis of PBL is incompletely understood, however association with the Epstein-Barr virus (EBV) and the MYC gene, have been identified as important pathogenic mechanisms. Aims and …
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Sporadic Burkitt Lymphoma in Adults; Clinico-pathologic Characteristics and Immunohistochemical Study
… outcome of patients with sporadic Burkitt lymphoma (BL) in adults. METHODS: A survey of 1,422 NHL patients who had been diagnosed at Korea Institute of Radiological & Medical Sciences between 1993 and 2003 identified 26 patients with BL (1.8%). All these cases were reviewed by experienced …
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Burkitt and Burkitt-like lymphoma/leukaemia at Groote Schuur Hospital from 2005 to 2014: a retrospective review
… population is at increased risk of developing non-Hodgkin lymphoma, particularly high grade aggressive subtypes such as Burkitt- and Burkittlike lymphoma (also known as B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma). …
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Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy
… to other small round blue cell tumors, including non-Hodgkin lymphoma, rhabdomyosarcoma, and Ewing sarcoma. One method of judging neuroblastoma aggressiveness uses tumor histology factors, including mitosis-karyorrhexis index, Schwannian stromal development, degree of differentiation, and patient …
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Cancer incidence by Ethnic Group in England, 2001-2007
… incidence of all major cancers in the six main ‘non-White’ ethnic groups in England to each other and to Whites using self-assigned ethnicity. A secondary objective is to compare these incidences with their countries of origin. Methods All cancer registrations from 2001–2007 in England were …
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Épissage alternatif et mutations ponctuelles de Pax5 chez la leucémie lymphoîde chronique et les lymphomes de cellules B
… in certain cases of B-cell malignancies such as non-Hodgkin lymphoma and acute lyrnphoblastic leukemia. Recent studies have revealed that the Pax5 transcript is subject to alternative splicing, thus producing multiple protein isoforms. Certain splicing events create a shift in the reading-frame …
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Understanding the molecular pathogenesis of HIV-associated Burkitt Lymphoma – the impact of HIV-1 protein Tat on lymphoma driver genes
Burkitt Lymphoma (BL) is a B cell non-Hodgkin lymphoma that occurs as three distinct subtypes, namely: endemic, sporadic, and immunodeficiency/HIV-associated. This cancer represents a frequent cause of mortality among HIV+ people in Southern Africa which has the highest incidence of HIV/AIDS …
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The biological effects of HIV-1 Nef on the development of B-cell Lymphoma
… compared to the rest of the world. Burkitt lymphoma (BL) is an extremely aggressive cancer that is considered to be a highly prevalent subtype of Non-Hodgkin Lymphoma (NHL) affiliated with chronic HIV infection. While the immunosuppressive aspect of HIV remains a primary cause for the …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
Anaplastic Lymphoma Kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is a T-cell non-Hodgkin lymphoma characterised by a chromosomal rearrangement [t(2;5) (p23;q25)] involving the ALK and NPM1 genes on chromosomes 2 and 5 respectively. This translocation generates the NPM-ALK fusion …
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