Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"non-CpG methylation"”.
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The Placenta Methylome: Novel Insights into DNA Modifications in the Human Placenta
The DNA methylation profile of the placenta is unique as compared to other somatic tissues and is marked by global hypomethylation. The placental methylome has been shown to modulate developmental processes, intrauterine exposures, and placental function. However, the precise mechanisms underlying …
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Investigating the molecular dynamics of gene re-silencing following treatment with epigenetic therapies
… silencing of genes by promoter hypermethylation is an important mechanism of tumour suppressor gene (TSG) inactivation in cancer. DNA hypomethylating agents such as 5-Aza-2’deoxycytidine (5-Aza-dC) are approved for the treatment of myelodysplastic syndrome and show promise in the …