Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"non melanoma skin cancer"”.
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
Non-melanoma skin cancers, the most common cancers in the United States, result from chronic exposure to ultraviolet irradiation (UV). UV-induced DNA damage activates cell cycle checkpoints through a mechanism involving degradation of the cyclin dependent kinase activators, the cell division cycle …
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Men and Women are Not Just From Different Planets: The Role of Sex-Based Differences in the Prevention of Non-Melanoma Skin Cancer
There are over 3.5 million new diagnoses of skin cancer each year in more than 2 million patients, making skin cancer more prevalent than all other cancers. While the risk of developing cutaneous squamous cell carcinoma, the more deadly type of non-melanoma skin cancer, is three times greater in …
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Molecular Dynamics of p21 and Fluorescent Sphingomyelin in Keratinocytes Exposed to UVB
<p>Non-melanoma skin cancer (NMSC) is the most common malignant tumor, representing more than a third of all malignant tumors combined and the incidence is increasing every year. Ultraviolet (UV) radiation from the sun is the most dominant factor contributing to tumor initiation and progression. …
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Nové diagnostické metody v dermatologii: neinvazivní diagnostika nemelanomových nádorů kůže
Non-melanoma skin cancer (NMSC) is the most prevalent cancer in the light-skinned population. New less- or non-invasive treatments are increasingly used for NMSC patients, making the development of non-invasive diagnostic technologies highly relevant. The scope of this work is to present data on …
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Health-Related Quality of Life in Morphea
… internal organs. Patients with morphea had worse skin-specific HRQOL than those with other skin diseases, including non-melanoma skin cancer, vitiligo, and alopecia (lowest P <.0001). The morphea population was found to have significantly worse global HRQOL scores than the general U.S. population …
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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
Skin cancer is the most common cancer worldwide, and its incidence rate in South Africa is increasing. Photodynamic therapy (PDT) has been shown to be an effective treatment modality, through topical administration, for treatment of non-melanoma skin cancers. Our group investigates …
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Cutaneous Human Papillomaviruses
… Cutaneous HPVs are frequently found in healthy skin and some types have also been implicated in non-melanoma skin cancer in immunocompetent as well as in immunosuppressed individuals. However, data on whether these infections persist over time is limited. We recently reported that in a cohort of …
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Characterising the biological response to ultraviolet radiation
… carcinogen, the ability of UVA alone to induce Non-melanoma skin cancer is well accepted and although more controversial there is now significant evidence from epidemiological studies and animal models to suggest a role for UVA in the development of melanoma. Furthermore due to its high …
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Invasion and Proliferation in Malignant Cells
… the relation to proliferation and invasion in non-melanoma skin cancer and in breast cancer. In a model system of basal cell carcinoma, we observed that tumor cells changed phenotype from a highly proliferative type in the centre of the tumor to an invasive type with low proliferation and a …
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The Use of Sphingomyelin to Protect Against UV Induced DNA Damage in Human Keratinocytes
<p>Non melanoma skin cancer (NMSC) is a serious condition caused by chronic ultraviolet (UV) exposure that leads to DNA damage in skin. UV radiation has the potential to lead to DNA damage, which triggers biochemical pathways within a cell. The result is that the cell either undergoes cell cycle …
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Novel Cutaneous Human Papillomaviruses and Biomarkers in the Skin Lesions
Non-melanoma skin cancer (NMSC), comprising of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), is the most prevalent cancer amongst Caucasians. The main risk factor for the development of NMSC is UV-irradiation but human papillo-mavirus (HPV) might be a co-factor. We extended the …
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Human papillomaviruses in skin cancer and cervical cancer
… papillomavirus (HPV) and development of cervical cancer is well established. In contrast, the significance of infections with cutaneous HPV for development of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated whether seropositivity to cutaneous HPV is a marker for cutaneous …
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Is melanoma associated leucoderma (MAL) a distinct entity compared to classial vitiligo?
… nitrative stress and signs for DNA-damage in the skin and in the plasma, these patients have no higher prevalence for sun induced non-melanoma skin cancer and increased photo-damage. Protection and DNA-repair have been attributed to a functioning up-regulated wild type p53 / p21 cascade in …
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Periocular malignancy.
… (5-8%), sebaceous gland carcinoma (2-3%) and melanoma (1%). The eyelids represent a high risk area for recurrence and are also functionally integral to the protection of the eye. Hence, surgical excision in this crucial region is best peformed with intraoperative histological margin control to …
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Diversity of Skin Infections
The identification of infectious agents in cancer has been one of the most rewarding endeavors in cancer research. Currently about 20% of the global cancer burden is linked to an infection. A common characteristic of virus-induced cancer is an increased incidence in immunosuppressed patients, …
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MODEL OF ESTIMATION OF LOCAL CONTROL AND SURVIVAL BENEFIT OF EXTERNAL BEAM RADIOTHERAPY FOR SELECTED CANCERS
… (OS) benefits of radiotherapy for selected cancers if the whole cancer population in Australia were treated according to evidence-based guidelines. These estimates were based on the published radiotherapy utilisation (RTU) models used for estimating demand of radiotherapy services nationally …
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Utility Of The Information-Motivation-Behavioral Skills Model In Measuring And Predicting Protection Behaviors Among Skin Cancer Patients
… among individuals previously diagnosed with non-melanoma skin cancer (NMSC), since they have a considerably higher risk of new NMSC and malignant melanoma; the most lethal form of skin cancer (Nahar et al., 2015). The objective of the current study was to examine the utility of the …
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Assessing the Photoprotective Effects of Fluorescent Sphingomyelin Against UVB Induced DNA Damage in Human Keratinocytes
<p>Non Melanoma Skin Cancer (NMSC) affects 3.3 million Americans each year and results from Ultra Violet Radiation (UVR) damage to DNA in the form of pyrimidine dimers and photoproducts [1]–[5]. Cells directly detect the damage and initiate apoptosis, cell cycle arrest, or DNA repair by modulating …
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Evaluation of teledermatology in the Veterans Health Administration
… than entry from an in-person referral for both melanoma (teledermatology median: 62 days; in-person consult median: 70 days; p=0.002) and non-melanoma skin cancer (teledermatology median: 79 days; in-person consult median: 88 days; p<0.001). There was little consistency in the …
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Malignant melanoma-Risk factors and the CDKN2A mutation in relation to phenotypes and other cancers.
Background: Cutaneous malignant melanoma (CMM) is an increasingly common cancer in fair-skinned people. The purpose of this thesis was to study high-risk patients with multiple tumours including a CMM, high-risk families with the unique Swedish germline mutation in CDKN2A(113insArg), as well as …
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