Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"noggin"”.
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NOGGIN Transport in a Model Human Epiblast
… manner, BMP4 directly induces the expression of NOGGIN. In this work, I interrogate the interplay of the morphogen/inhibitor pair BMP4/NOGGIN within our model of the polarized human embryonic disc. Here, I report the surprising discovery that in human epiblasts, NOGGIN and BMP4 were selectively …
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The role of bone morphogenetic protein signalling in the control of skin repair after wounding. Cellular and molecular mechanisms of cutaneous wound healing mediated by bone morphogenetic proteins and their antagonist Noggin.
… Smad1 (K14-caSmad1) or the BMP antagonist Noggin (K14-Noggin) were utilised, together with human and mouse ex vivo wound healing models and in vitro keratinocyte culture. In wild-type mice, transcripts for Bmpr-1A, Bmpr-II, Bmp ligands and Smad proteins were decreased following tissue …
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A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells
… the bone morphogenetic protein (BMP) antagonist Noggin is expressed by ependymal cells and that SVZ cells express BMP s as well as their receptors. In vitro, BMP signaling potently inhibited neurogenesis. Conversely, Noggin protein in vitro promoted neurogenesis. Overexpression of BMPs in …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… a transgenic expression of the BMP antagonist Noggin was targeted to the epidermis and hair follicles (HFs) via Keratin 14 promoter. K14-Noggin mice developed spontaneous HF-derived tumours, which resembled human trichofolliculoma. Initiation of the tumours was associated with a marked increase …
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An Investigative Study Into the Relationship of Bone Morphogenetic Protein Antagonist Expression and Osteocyte Density by Region and Quadrant
… immunohistochemically stained for gremlin and noggin expression and also underwent methyl green staining to determine osteocyte presence. Bone sections were divided into four quadrants (cranial, caudal, medial and lateral) and three regions (proximal, mid shaft and distal), followed by analysis …
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Natural Polymeric Carriers for Local Delivery of Therapeutic Agents to Promote Enhanced Bone Regeneration
… dose, targeting rhBMP-2 antagonists such as noggin through substrate-mediated delivery of siRNA complexes can potentially increase local rhBMP-2 efficacy. Fibrin, a natural polymer involved in bone healing, is able to electrostatically bind siRNA complexed with polycationic transfection …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… in acute SCI by utilizing two BMP inhibitors, noggin and LDN193189. We also utilized primary in vitro systems to determine the cell-specific effects of BMP4 on spinal cord neural stem/progenitor cells (NPCs), oligodendrocyte precursor cells (OPCs), astrocytes and neurons. Here, for the first …
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Cellular principles of Xenopus appendage regeneration
… express inhibitory secreted factors, including NOGGIN, blocking AER cell formation. Inhibitory factors can be overridden by the application of FGF10 which operates upstream of the effect of NOGGIN, prevents chondrogenesis, and restores regeneration. As mammals have AER in their embryonic …
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Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
… of Smad4, treatment with the BMP antagonist noggin, or the BMP receptor inhibitor dorsomorphin blocked serum induction of Id1. Further, BMP2 is sufficient to induce Id1 expression. Given reports that SRC inhibitors can block Id1 expression, we tested the SRC inhibitor, AZD0530, and found that …
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The effects of BMP4 on different in vitro models for mouse gastrulation and neural induction
… neural induction and that a BMP4 antagonist (Noggin) enhances neural differentiation in this system.
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Bmp proteins in urodele myotube cell cycle re-entry and in regeneration
… dose-dependent manner by the known bmp-inhibitor noggin. Finally, we showed that inhibition of Bmp signaling in vivo causes defects in axolotl tail regeneration.
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BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality
… of BMP signaling via the secreted BMP antagonist Noggin in the pre-pancreatic milieu results in reduced pancreas, spleen, stomach and in failure of pyloric sphincter formation. Interestingly, BMP knockdown also results in defects in lateral growth of the pancreas. Specifically, BMP knockdown …
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Die Rolle von cDermo-1 und cTwist im Vogelembryo
… as an FGF-4 signal, while it is inhibited by Noggin. The dorsolateral progenitor cells deepithelialise out of the central dermomyotome where they express En-1, which is downregulated by BMP, promoting the dermis development in the area directly overlying the somites. These cells also express …
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Exploring Molecular Mechanisms Controlling Skin Homeostasis and Hair Growth. MicroRNAs in Hair-cycle-Dependent Gene Regulation, Hair Growth and Associated Tissue Remodelling.
… transgenic mice over-expressing BMP antagonist Noggin. Transfection of the keratinocytes with miR-21 mimic revealed existence of two groups of the BMP target genes, which are differentially regulated by miR-21. Thus, this suggests a novel mechanism controlling the effects of BMP signalling in …
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Application and Development of Advanced Genetic Tools to Study Adult Stem Cells
… insensitive to withdrawal of the BMP inhibitor Noggin. Moreover, potential substrate candidates located at the cell surface membrane were identified and the generation of in vivo models initiated to provide a basis for further studies investigating the role of these E3s. In trying to address the …