Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"nodes of Ranvier"”.
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Anti-GD1a antibody targeted disruption of the node of Ranvier in a mouse model of acute motor axonal neuropathy
… junction, leaving this terminal portion of the axon unprotected. It is here that susceptibility to antibody attack in a mouse model of GBS has previously been demonstrated. It was the aim of this thesis to determine to what extent more proximal portions of the distal axon are at risk from …
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Using Lipid Bilayers in an Artificial Axon System
Since the rise of multicellular organisms, nature has created a wide range of solutions for life on Earth. This diverse set of solutions presents a broad design space for a number of bio-inspired technologies in many different fields. Of particular interest for this work is the computational and …
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The role of complex gangliosides in glial cell biology
Gangliosides are a family of sialic acid-containing glycosphingolipids that are enriched in the nervous system. They are located in the outer leaflet of the plasma membrane within lipid rafts and are thought to be involved in numerous cellular events, including proliferation, differentiation, …
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Biophysical and Structural Studies of CNTNAP2
… interaction networks. CNTNAP2 is a member of the neurexin superfamily of synaptic cell adhesion molecules; it is localized at the juxtaparanodes of myelinated axons at the Nodes of Ranvier where it mediates interactions between neurons and ensheathing glial cells and recruits potassium …
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The Role of Sulfatide in Alzheimer's Disease
… (AD) is characterized by the accumulation of amyloid beta plaques, neurofibrillary tangles (NFT) and loss of cortical neurons that control memory and cognition. The cause of NFTs and Aβ plaques is not clear, though it is known that they are formed by enzymes which are preferentially …
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Investigating the assembly of axonal domains for saltatory conduction
The assembly of functional axonal domains including the axon initial segment (AIS) and nodes of Ranvier in myelinated fibres are essential in promoting nerve impulse conduction in the vertebrate central and peripheral nervous system (CNS and PNS). We still do not fully understand what determines …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… that adult neurogenesis (the production of functionally mature neurons from progenitor cells in the adult mammalian brain) is linked to the etiology of many neurodegenerative and psychiatric disorders. Studies have shown that neurogenesis is clearly a multifactorial and complex process …
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A neural and behavioural investigation of aberrant feeding in animal models of autism spectrum disorder
… disorder affecting approximately 1.85% of the population, is underpinned by complex interplay between genetics and environment. Thus far, ASD research has focused predominantly on abnormal social communication, anxiety, and cognitive impairments. It omits, however, dysregulated food …