Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"nociceptors"”.
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Investigating Mechanisms In Nociceptors Driving Ongoing Activity and Ongoing Pain
… evidence suggests ongoing activity in nociceptors is a major driver of ongoing pain. Ongoing activity can be generated in sensory neurons in the absence of sensory generator potentials if one or more of three neurophysiological alterations occur – prolonged depolarization of resting …
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Trpv1 Channels Contribute to Behavioral Hypersensitivity and Spontaneous Activity In Nociceptors After Spinal Cord Injury
… increase in spontaneous activity in primary nociceptors, which is correlated significantly with mechanical allodynia and thermal hyperalgesia. Upregulation of ion channel transient receptor vanilloid 1 (TRPV1) has been observed in the dorsal horn of the spinal cord after SCI, and reduction of …
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MRGX1-TRPAI in inflammatory pain signalling
… of specialised primary sensory neurons known as nociceptors. Nociceptors detect noxious (painful) stimuli to evoke pain sensation via the activation of Transient Receptor Potential Ankyrin 1 (TRPA1). TRPA1 activity can be modulated by G-Protein Coupled Receptors (GPCR), leading to sensitisation …
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Modulation of the sensitivity of nociceptive neurones by cannabinoids and SNSR
… by specialised primary sensory neurones called nociceptors. Modulation of the sensitivity of these nociceptors occurs physiologically when they are exposed to inflammatory exudates. A fuller understanding of the means by which these neurones are modulated will provide relevant information for …
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Investigating the Role of Insulin-Like Signaling in Paclitaxel-Induced Nociceptive Hypersensitivity using Drosophila melanogaster
… larval stage. Live imaging of peripheral thermal nociceptors showed that this hypersensitivity precedes observable neuronal damage. At low concentrations, PTX caused hyper-sprouting of tertiary dendritic spines in peripheral nociceptors. At high concentrations, it caused dendritic degradation. We …
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Neuronal and Molecular Basis of Nociception and Thermosensation in Drosophila melanogaster
… of pain detecting peripheral sensory neurons (nociceptors) that can detect noxious mechanical, thermal or chemical stimuli. On the other hand, animals also have the ability to discriminate innocuous temperatures and to direct their locomotions to their favorable environmental temperatures and …
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Behavioral Insights Into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms In Rats
… linked to ongoing activity (OA) in human C-fiber nociceptors. Preclinical studies using rodent neuropathic models have concentrated on allodynia driven by OA generated in non-nociceptive Aβ fibers, but little attention has been paid to postsurgical pain in sham controls or to C-fiber nociceptor OA …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… The majority of cold sensitive A and C fibre nociceptors as well as thermoreceptors were sensitive to menthol, indicating that TRPM8 is the transducer of cold on these afferents. The poor correlation of TRPA1 expression and cold sensitivity in nociceptive A and C fibres indicates that TRPA1 is …
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Investigation into the molecular mechanisms of congenital insensitivity to pain
… either to direct development or function of nociceptors. In this dissertation, a number of unrelated families with CIP were recruited and novel missense and splicing mutations in NTRK1, NGF and SCN9A were identified in the cohort. The findings presented in this dissertation demonstrate how …
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Investigating novel therapeutic targets for treatment of visceral pain.
… disease by inhibiting the activation of colonic nociceptors. Next, we studied the pro-nociceptive potential of angiotensin II (Ang II) and matrix metalloproteinase-1 (MMP1) by examining their effect on colonic afferent activity and mobilisation of intracellular Ca2+ in sensory neurons isolated …
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
… thesis support the hypothesis that trigeminal nociceptors can directly detect and respond to pathogenic challenge and tissue damage. The acute activation of TLRs, expressed by trigeminal nociceptors, results in the up-regulation of pro-inflammatory cytokines which are known to activate and …
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A Role For Epac1 and Epac2 In Nociceptor Hyperexcitability and Chronic Pain After Spinal Cord Injury
… OA incidence could be significantly decreased in nociceptors isolated from Epac1<sup>-/- </sup>and Epac2<sup>-/- </sup>mice by inhibition of the complementary EPAC isoform. Behavioral measures of “pain” did not show significant differences between WT and EPAC2<sup>-/-</sup> mice in a naïve state …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… and mice with a conditional deletion of ERK2 in nociceptors: ERK2f/f;NaV1.8-Cre) were used. Although both isoforms are activated: phosphorylated) following inflammation, deletion of ERK1 had no effect in several models of chemical nociception, inflammatory pain, and neuropathic pain. In contrast, …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… can lower the activation threshold of primary nociceptors in TMD patients.</p>
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Effects of Single and Dual Orexin Receptor Antagonists on Trigeminal Nociception
… which relays nociceptive signaling from primary nociceptors to the hypothalamus. Orexins are excitatory, hypothalamic neuropeptides implicated in pain pathways, as well as regulation of sleep and hunger. More specifically, orexins are involved in trigeminal nerve transmission of migraine pain by …
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Damage-Induced Inflammation and Nociceptive Hypersensitivity In Drosophila Larvae
… required for hypersensitivity in pain receptors (nociceptors), and discovered a number of novel mediators that have well conserved mammalian homologs. Together, these results help us to understand how various cell types in the immune and nervous systems both detect and respond to tissue damage.
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Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine
… and central sensitization of trigeminal nociceptors. An in vivo animal model was used to determine if two novel drugs in development and Topiramate, a common drug used to treat frequent migraine, could inhibit nocifensive responses to mechanical stimulation of trigeminal neurons. In …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
… lipopolysaccharide (LPS). Stimulation of lung nociceptors induced acute stress responses in the paraventricular hypothalamic nuclei by activating corticotropin-releasing hormone neurons responsible for sickness behavior and hypothermia. Once bacteria enter the bloodstream, an immune paradox …
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Investigating the Cell-specific Mechanisms That Drive Sex Differences During Neuropathic Pain Development
… suggests that immune-related components of nociceptors are heavily dysregulated following insult and are more directly responsible for changes in female-specific sensitization. Despite advances in the field of pain neurobiology, there remains a clear disconnect between the cellular …
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