Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"nociceptor"”.
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Secondary Traumatic Stress Promotes Peripheral Trigeminal Nociceptor Sensitization
Migraine is a leading cause of pain and disability in the United States, especially among women. Migraineurs are characterized by a hyperexcitable or hypervigilant nervous system that during an attack, leads to hyperalgesia and allodynia. Sensitization and activation of peripheral trigeminal …
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Sensory Neurogenesis and the Role of PRDM12 in Nociceptor Development and Function
Nociceptors are a set of peripheral neurons responsible for the detection of noxious stimuli. They function to alert us to the presence of potentially damaging internal and environmental threats, thereby playing an important role in allowing us to react and avoid danger. Unfortunately, for over 30% …
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A Role For Epac1 and Epac2 In Nociceptor Hyperexcitability and Chronic Pain After Spinal Cord Injury
… play a key role in the maintenance of persistent nociceptor hyperexcitability and chronic pain after SCI.</p> <p>Using both a T9 SCI mouse model and a T10 SCI rat model, we employed behavior assays and electrophysiological techniques to characterize the role of EPAC1 and 2 in SCI-induced pain. We …
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Behavioral Insights Into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms In Rats
… linked to ongoing activity (OA) in human C-fiber nociceptors. Preclinical studies using rodent neuropathic models have concentrated on allodynia driven by OA generated in non-nociceptive Aβ fibers, but little attention has been paid to postsurgical pain in sham controls or to C-fiber nociceptor OA …
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Investigating the Cell-specific Mechanisms That Drive Sex Differences During Neuropathic Pain Development
… suggests that immune-related components of nociceptors are heavily dysregulated following insult and are more directly responsible for changes in female-specific sensitization. Despite advances in the field of pain neurobiology, there remains a clear disconnect between the cellular …
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Investigating Mechanisms In Nociceptors Driving Ongoing Activity and Ongoing Pain
… evidence suggests ongoing activity in nociceptors is a major driver of ongoing pain. Ongoing activity can be generated in sensory neurons in the absence of sensory generator potentials if one or more of three neurophysiological alterations occur – prolonged depolarization of resting …
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Angiotensin II signalling in sensory neurons
… of NFAT5 may indicate prolonged changes in nociceptor properties induced by Ang II, as evidenced by an increase in electrical excitability of IB4-binding neurons following overnight Ang II incubation. In summary, experiments detailed in this Thesis have revealed that Ang II stimulated …
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Neuroepithelial Signalling in the Colon
… gut mucosa may also contribute to TRPV4-mediated nociceptor stimulation. Several gut hormone receptors are also expressed including cholecystokinin (CCK) which is associated with a worsening of postprandial abdominal pain and visceral hypersensitivity in IBS. Consequently, this thesis sought to …
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CaMKIIbeta in Pain and Addiction
… specific CaMKIIβ knockout mice I determined that nociceptor specific CaMKIIβ mediates both evoked and on-going spontaneous pain in both chronic inflammatory and neuropathic pain models. I employed hematopoietic stem cell transplantation to induce sickle cell in transgenic mice and discovered that …
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
… that these receptors are primarily expressed by nociceptor sub-populations. Acute activation of these TLRs, in TG neurons, induced an increased gene expression of the pro-inflammatory cytokines, TNF and IL-1 . In an attempt to identify further novel co-modulators of neuronal TLR activation, the …
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A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain
… were established and substance P (SP; marker of nociceptor terminals) immunohistochemistry used to investigate changes in immunoreactivity of DRG terminals in the thoracic dorsal horn (segments T9-T13). SP immunoreactivity was increased in the dorsal horn (4 fold; P < 0.001) and central canal (P …
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Group III mGluR8 negatively modulates TRP channels
… occur through modulation of TRP channels on nociceptors. The following studies used a multifaceted approach to examine the interaction between group III mGluRs (mGluR8) and two TRP channels: TRPV1 and TRPA1. In the first study, we examined the interaction between group III mGluRs and TRPV1. …
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Neurochemical drivers of visceral pain: insights into the roles of interleukin-17 and the proton-sensing G protein-coupled receptor GPR68
… co-expression of its receptor, Il17ra, with the nociceptor marker Trpv1 in murine colon-projecting sensory neurons. Using Ca2+-imaging of dorsal root ganglion (DRG) neurons, including neuron-enriched cultures generated by magnetic-activated cell sorting, I demonstrated that IL-17 directly …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
… neurons (iPSCSNs) were differentiated into a nociceptor-like phenotype and cultured with human primary skin cells to form deconstructed skin models. This included compartmentalized culture chips for examining neuronal innervation and an insert-based format with shared culture medium to observe …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… and mice with a conditional deletion of ERK2 in nociceptors: ERK2f/f;NaV1.8-Cre) were used. Although both isoforms are activated: phosphorylated) following inflammation, deletion of ERK1 had no effect in several models of chemical nociception, inflammatory pain, and neuropathic pain. In contrast, …
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Treatment of musculoskeletal pain with the sting of the stinging nettle: Urtica dioica
… the known serotonin and histamine involvement in nociceptor activation, capsaicin substance P depletion and thermal hyperalgesia (possibly similar to nettle sting), transcutaneous electrical nerve stimulation (TENS) analgesia, and the gate control theory. Osteoarthritis Its clinical features, …
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Neural Circuit Dependence of Acute and Subacute Nociception in C. Elegans
… the dynamic properties of a classical nociceptor in C. elegans, the polymodal sensory neuron ASH, and asked how these properties instruct downstream circuits and behavior. I thus first elucidated ASH calcium activation dynamics using simple step responses and using a newly developed …
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TRPV1 ist ein polymodaler Rezeptor von nozizeptiven Spinalganglienzellen
In der vorliegenden Arbeit wurde mittels der Whole-Cell Patch-Clamp Methode sensible Neurone von transgenen Mäusen untersucht, bei denen das Gen für TRPV1 (transient receptor potential V1) deletiert wurde. Das Ergebniss wurde mit den Daten von Wildtyp Mäusen verglichen. TRPV1 (früher VR1; vanilloid …
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Axillary web syndrome after treatment for breast cancer: An exploration of imaging evidence of fascial changes and its relationship to clinical variables
… limitations, explaining reduced ROM and nociceptor activation as seen in pain reported in the study. A fibrosed vessel damaged during axillary surgery as well as surrounding fascial changes, which occurred as the result of the healing response, could explain the varying appearances of the …