Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"nociceptive sensitization"”.
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Tnf Signaling During Tissue Damage-Induced Nociceptive Sensitization In Drosophila
… (TNF) signaling is required for inflammatory nociceptive sensitization in both <em>Drosophila</em> and vertebrates. In <em>Drosophila</em> larval model of nociceptive sensitization, UV irradiation in results in epidermal apoptosis and thermal allodynia. TNF/Eiger is produced from dying …
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Cellular and Genetic Bases of Cold Nociception and Nociceptive Sensitization In Drosophila Larvae
… for noxious cold perception and injury-induced nociceptive sensitization using the genetically tractable <em>Drosophila</em> model. Using a novel "cold probe" tool and assay we found larvae produce a mutually exclusive set of reactive behaviors to a defined noxious cold stimulus (3-12 ºC), …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… to be key signaling molecules in nociception and nociceptive sensitization. Studies utilizing inhibitors targeting the shared ERK1/2 upstream activator, mitogen-activated protein kinase kinase: MEK), and transgenic mice expressing a dominant negative form of MEK have established the importance of …
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Modeling Alterations In Nociception Following Repeated Vaso-Occlusive Episodes
… Administration of ET-1 during infancy results in nociceptive sensitization in male rats and nociceptive de-sensitization in female rats via modulation of endothelin-B (ETB) receptor. This thesis focuses on the hypothesis that exposure to ET-1 early in development alters nociception later in …