Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"nitrosylation"”.
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S-nitrosylation mediates synaptic plasticity in the retina
… modification of proteins called S-nitrosylation and if it contributes to the modulation of the dynamic range of vision. In the central nervous system, including the retina, S-nitrosylation has not been considered to be significant under physiological conditions, and instead, has …
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A role for glutathione in reactions between oxidants and proteins
… The NO donor S-nitrosoglutathione caused S-nitrosylation of H-Ras on four cysteine residues;Within NIH/3T3 cells overexpressing H-Ras, H-Ras was S-glutathiolated on multiple thiols by diamide. At least one of the cysteine residues modified in cells by diamide is normally lipidated, …
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Modulation of calcium signalling in human sperm by nitric oxide
… of NO, GSNO and dithiothreitol on protein S-nitrosylation, assessed using the biotin-switch assay, closely paralleled their actions on [Ca\(^{2+}\)]\(_i\). Progesterone mobilizes stored Ca\(^{2+}\) in human sperm, by a mechanism involving ryanodine receptor (RyR) activation. Pre-treatment …
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Nitric oxide induces chromatin remodelling in the developing central nervous system
… neurons upon BDNF stimulation, thereby inducing Snitrosylation of a wide array of nuclear proteins. S-nitrosylation of histone deacetylase 2 (HDAC2) decreases its affinity for chromatin, leading to increased histone acetylation levels. This NO-dependent regulation of HDAC2 promotes changes in …
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Modulation of Hypoglossal Motoneurons by Nitric Oxide
… of a background TASK-like conductance and an S-nitrosylation-dependent activation of the instantaneous but not the time-dependent component of the hyperpolarization-activated current (Ih) generated by hyperpolarization-activated cyclic nucleotide gated (HCN) channels. These results suggest that …
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EFFECTS OF RED BLOOD CELLS ON NITRIC OXIDE BIOACTIVITY
… is preserved in as a nitrosothiol through a nitrosylation process. Our result found that the nitrite bioactivation is involved surface protein nitrosation. Nitric oxide synthase (NOS) is an enzyme for converting L-arginine to NO and citrulline. Arginase as another enzyme converts L-arginine …
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Characterizing RyR and SERCA function in the C57 and D2 mdx mouse models of Duchenne Muscular Dystrophy
… under reducing conditions, protein nitration and nitrosylation content were significantly higher in D2 mdx gastrocnemius muscles. Further, pre-treatment with dithiothreiotol (DTT) did not improve SR Ca2+ handling in these muscles, suggestive of irreversible reactive oxygen/nitrogen …
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Repulsive cues and signalling cascades of the axon growth cone
… relation to Spalmitoylation, the reciprocal of S-nitrosylation, I propose that nitric oxide causes collapse by crossing the cell membrane to inhibit S-palmitoylation–determined localisation of proteins. These results reveal some of the many pathways involved in growth cone collapse, whose further …
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DEVELOPMENT OF MICROCHIP ELECTROPHORESIS BASED METHODS TO PROFILE CELLULAR NITROSATIVE STRESS
… (ONOO-). These two RNS are capable of nitration, nitrosylation and oxidation of intracellular biomolecules that can alter various biochemical processes. To help maintain cellular redox homeostasis in nitrosative and oxidative stress, antioxidant molecules are present in the cells. However, …
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Charakterisierung genomischer Polymorphismen und somatischer Mutationen, sowie der Expression der gastrointestinalen Glutathionperoxidase im Rahmen der kolorektalen Karzinogenese
… ab, das seinerseits ein starkes Agens bei der Nitrosylation von Biomolekülen ist. Zusätzlich reduziert Selenoprotein P auch Phospholipid-Hydroperoxide, wenn auch weniger effektiv als PH-GPx. Es konnte in Vorarbeiten gezeigt werden, dass Selenoproteine im Gastrointestinaltrakt eine …
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Redox Regulation of Akt Phosphorylation in PTEN-/- Mouse Embryonic Fibroblasts
… Akt via an oxidative inhibition of PTEN by S-nitrosylation. During the course of this study, it was noticed that in mouse embryonic fibroblasts that do not express the tumour suppressor PTEN (MEFPTEN-/- cells), a decrease in the intracellular level of O2.- abrogated the hyperphosphorylation of …
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Study of Erythroid Antioxidant Depletion in Childhood Obesity
… glutathione metabolism, generation of oxidation/nitrosylation products of nucleic acid, proteins, and lipids), various pathways related to energy metabolism (e.g., glycolysis, pentose phosphate pathway, lipid ß-oxidation, tricarboxylic acid cycle), homeostasis of amino acids (particularly …
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Protein engineering using azurin as the scaffold: capturing and studying novel metal-sulfenate and metal-NO species
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2018-05-01
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Reactions of S-nitrosothiols with biomimetic iron complexes and other transition metals
… with [FeIIITPP)Cl] resulted in reductive nitrosylation of the iron center. The reaction of the [2Fe-2S] cluster with both S-nitrosothiols led to the formation of reduced Roussin's black anion. The reaction of the mononuclear complex [Fe(BLPhMe)C1₂] with both S-nitrosothiols led to …